Between the 2003 and 2008 seasons, Johan Santana won the most games, with 98 wins.

Interpreted as:

most regular-season wins by a player from 2003 to 2008

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Johan Santana J. Santana	98	42	.700	213	186	2.85	1,358	9	6	0	1305.0	1,038	413	444	143	308	25	7	7	5,200	41	9.37	2.12	4.41	0.99	26.1	5.9	1.03	.266	3.06	65	3.21	74	7.16	162.7
2	Roy Oswalt R. Oswalt	96	52	.649	190	187	3.20	983	12	5	0	1247.1	1,232	443	478	105	284	47	1	20	5,167	14	7.09	2.05	3.46	0.76	19.0	5.5	1.22	.301	3.45	74	3.41	77	8.89	140.4
3	Roy Halladay R. Halladay	94	42	.691	173	172	3.24	884	35	8	0	1232.0	1,171	443	487	102	210	37	0	15	4,975	21	6.46	1.53	4.21	0.75	17.8	4.2	1.12	.286	3.56	71	3.34	74	8.55	155.3
4	Carlos Zambrano C. Zambrano	91	51	.641	193	193	3.39	1,075	8	3	0	1266.0	1,053	477	525	105	549	67	0	28	5,341	35	7.64	3.90	1.96	0.75	20.1	10.3	1.27	.267	3.73	76	3.93	88	7.49	73.4
5	Mike Mussina M. Mussina	88	51	.633	182	181	3.99	882	6	3	0	1108.2	1,155	492	533	119	228	29	0	11	4,597	19	7.16	1.85	3.87	0.97	19.2	5.0	1.25	.310	4.33	90	3.59	81	9.38	102.1
6	Andy Pettitte A. Pettitte	87	57	.604	186	183	3.83	907	3	1	0	1147.1	1,195	488	544	108	316	14	1	19	4,843	22	7.11	2.48	2.87	0.85	18.7	6.5	1.32	.311	4.27	87	3.61	82	9.37	103
7	CC Sabathia	87	57	.604	188	188	3.43	1,073	24	10	0	1269.0	1,194	484	529	114	340	42	0	12	5,242	18	7.61	2.41	3.16	0.81	20.5	6.5	1.21	.294	3.75	78	3.48	80	8.47	120.5
8	Brandon Webb B. Webb	87	62	.584	198	197	3.24	1,063	15	8	0	1315.2	1,194	473	551	90	433	49	1	34	5,495	56	7.27	2.96	2.45	0.62	19.3	7.9	1.24	.286	3.77	71	3.47	77	8.17	149.5
9	Derek Lowe D. Lowe	85	67	.559	203	201	4.00	778	8	2	0	1236.1	1,272	550	645	108	357	31	1	18	5,254	17	5.66	2.60	2.18	0.79	14.8	6.8	1.32	.292	4.70	91	3.91	90	9.26	62
10	Jon Garland J. Garland	84	62	.575	195	193	4.41	636	8	5	0	1246.0	1,326	611	663	156	354	33	0	17	5,284	22	4.59	2.56	1.80	1.13	12.0	6.7	1.35	.285	4.79	96	4.63	101	9.58	-1.8
11	Mark Buehrle M. Buehrle	83	66	.557	199	199	3.91	786	14	3	0	1336.0	1,442	580	658	155	297	33	0	22	5,594	8	5.29	2.00	2.65	1.04	14.1	5.3	1.30	.298	4.43	84	4.16	89	9.71	71.4
12	Tim Hudson T. Hudson	82	51	.617	182	181	3.52	738	12	7	0	1205.1	1,166	472	514	89	342	50	0	40	5,034	29	5.51	2.55	2.16	0.66	14.7	6.8	1.25	.282	3.84	80	3.81	86	8.71	81.4
13	John Lackey J. Lackey	82	59	.582	189	188	3.83	993	12	7	0	1216.1	1,229	517	566	124	361	60	0	18	5,158	70	7.35	2.67	2.75	0.92	19.3	7.0	1.31	.305	4.19	86	3.83	88	9.09	74.1
14	Greg Maddux G. Maddux	82	75	.522	205	205	4.13	730	7	1	0	1258.0	1,326	577	633	143	194	36	0	30	5,205	20	5.22	1.39	3.76	1.02	14.0	3.7	1.21	.288	4.53	97	3.96	91	9.49	57.6
15	Jamie Moyer J. Moyer	82	60	.577	198	197	4.29	720	6	1	0	1224.0	1,290	583	622	169	360	48	1	20	5,255	12	5.29	2.65	2.00	1.24	13.7	6.9	1.35	.283	4.57	98	4.71	107	9.49	-41.2
16	Josh Beckett J. Beckett	81	53	.604	169	168	3.80	994	5	2	0	1057.0	975	446	477	110	316	39	1	11	4,399	35	8.46	2.69	3.15	0.94	22.6	7.2	1.22	.294	4.06	86	3.58	84	8.30	81.5
17	Ted Lilly T. Lilly	81	61	.570	189	188	4.28	929	2	1	0	1095.1	1,032	521	548	161	405	28	0	16	4,689	31	7.63	3.33	2.29	1.32	19.8	8.6	1.31	.275	4.50	94	4.50	100	8.48	1.3
18	Jake Peavy J. Peavy	80	55	.593	182	182	3.14	1,166	6	3	0	1163.1	983	406	430	117	374	41	0	27	4,786	20	9.02	2.89	3.12	0.91	24.4	7.8	1.17	.280	3.33	79	3.47	82	7.60	98.6
19	Jeff Suppan J. Suppan	79	59	.572	192	191	4.26	642	4	2	0	1160.2	1,272	550	612	141	383	46	0	30	5,054	35	4.98	2.97	1.68	1.09	12.7	7.6	1.43	.294	4.75	99	4.68	108	9.86	-44.7
20	Livan Hernandez L. Hernandez	78	70	.527	201	201	4.33	796	22	2	0	1335.0	1,477	643	683	166	424	45	0	37	5,768	17	5.37	2.86	1.88	1.12	13.8	7.4	1.42	.302	4.60	99	4.57	104	9.96	-25.5
21	Cliff Lee C. Lee	76	38	.667	158	154	4.18	713	7	2	0	954.2	973	443	487	117	281	33	1	8	4,066	25	6.72	2.65	2.54	1.10	17.5	6.9	1.31	.293	4.59	95	4.18	97	9.17	13.3
22	Javier Vazquez J. Vazquez	76	73	.510	197	196	4.27	1,180	11	2	0	1272.0	1,233	604	643	173	330	48	0	18	5,335	44	8.35	2.33	3.58	1.22	22.1	6.2	1.23	.294	4.55	94	3.90	86	8.72	87.3
23	Barry Zito B. Zito	76	76	.500	204	203	4.14	882	4	1	0	1270.2	1,166	585	639	140	542	49	0	24	5,449	24	6.25	3.84	1.63	0.99	16.2	9.9	1.34	.267	4.53	94	4.53	103	8.26	-16.2
24	Kenny Rogers K. Rogers	74	50	.597	173	170	4.44	546	3	2	0	1042.2	1,152	514	562	114	327	47	1	11	4,520	18	4.71	2.82	1.67	0.98	12.1	7.2	1.42	.298	4.85	96	4.53	102	9.94	-7.6
25	Tim Wakefield T. Wakefield	73	63	.537	184	180	4.42	753	5	0	1	1126.0	1,080	553	613	153	377	66	2	8	4,810	53	6.02	3.01	2.00	1.22	15.7	7.8	1.29	.268	4.90	96	4.70	109	8.63	-51