Dave Smith has the most career pitcher wins + saves for the Astros, with 252.

	NAME	W+SV	W	SV	L	W%	G	GS	ERA	SO	CG	SHO	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Dave Smith D. Smith	252	53	199	47	.530	563	1	2.53	529	0	0	762.0	646	214	254	28	260	12	400	57	3,145	27	6.25	3.07	2.03	0.33	16.8	8.3	1.19	.267	3.00	74	2.90	84	7.63	47.3
2	Billy Wagner B. Wagner	251	26	225	29	.473	464	0	2.53	694	0	0	504.1	333	142	149	48	191	18	379	15	2,027	28	12.38	3.41	3.63	0.86	34.2	9.4	1.04	.265	2.66	59	2.80	66	5.94	83.4
3	Joe Niekro J. Niekro	153	144	9	116	.554	397	301	3.22	1,178	82	21	2270.0	2,052	811	934	139	818	41	41	33	9,490	128	4.67	3.24	1.44	0.55	12.4	8.6	1.26	.262	3.70	95	3.59	104	8.14	-46
4	Brad Lidge B. Lidge	146	23	123	20	.535	378	1	3.30	561	0	0	401.0	310	147	160	38	170	26	206	22	1,684	32	12.59	3.82	3.30	0.85	33.3	10.1	1.20	.306	3.59	76	2.98	67	6.96	64.4
5	Roy Oswalt R. Oswalt	143	143	0	82	.636	303	291	3.24	1,593	19	7	1932.1	1,865	696	747	167	446	68	5	32	7,976	23	7.42	2.08	3.57	0.78	20.0	5.6	1.20	.298	3.48	76	3.35	77	8.69	217.7
6	Larry Dierker L. Dierker	138	137	1	117	.539	345	320	3.28	1,487	106	25	2294.1	2,090	837	927	177	695	48	9	43	9,492	102	5.83	2.73	2.14	0.69	15.7	7.3	1.21	.270	3.64	96	3.20	96	8.20	33.2
7	Ryan Pressly R. Pressly	128	18	110	20	.474	342	0	2.81	411	0	0	333.0	260	104	121	29	82	5	183	2	1,330	19	11.11	2.22	5.01	0.78	30.9	6.2	1.03	.288	3.27	68	2.63	63	7.03	58.9
8	Ken Forsch K. Forsch	128	78	50	81	.491	421	153	3.18	815	36	9	1493.2	1,439	528	587	96	428	26	171	58	6,213	36	4.91	2.58	1.90	0.58	13.1	6.9	1.25	.277	3.54	92	3.25	94	8.67	30.3
9	Mike Scott M. Scott	110	110	0	81	.576	263	259	3.30	1,318	42	21	1704.0	1,444	625	694	144	505	30	3	45	6,989	35	6.96	2.67	2.61	0.76	18.9	7.2	1.14	.260	3.67	94	3.26	93	7.63	45.3
10	J.R. Richard	107	107	0	71	.601	238	221	3.15	1,493	76	19	1606.0	1,227	562	625	73	770	17	3	15	6,674	92	8.37	4.32	1.94	0.41	22.4	11.5	1.24	.267	3.50	92	2.85	82	6.88	114.7
11	Nolan Ryan N. Ryan	106	106	0	94	.530	282	282	3.13	1,866	38	13	1854.2	1,441	645	739	111	796	44	0	31	7,716	104	9.05	3.86	2.34	0.54	24.2	10.3	1.21	.271	3.59	91	2.86	83	6.99	124.4
12	Don Wilson D. Wilson	106	104	2	92	.531	266	245	3.15	1,283	78	20	1748.1	1,479	611	698	119	640	47	10	32	7,305	77	6.60	3.29	2.00	0.61	17.6	8.8	1.21	.261	3.59	92	3.09	92	7.61	43.7
13	Joe Sambito J. Sambito	105	33	72	32	.508	353	5	2.42	421	1	1	536.0	441	144	168	35	155	8	229	26	2,157	11	7.07	2.60	2.72	0.59	19.5	7.2	1.11	.264	2.82	71	2.87	83	7.40	35
14	Shane Reynolds S. Reynolds	103	103	0	86	.545	274	248	3.95	1,309	20	7	1622.1	1,738	712	785	171	358	33	5	27	6,865	38	7.26	1.99	3.66	0.95	19.1	5.2	1.29	.314	4.35	95	3.58	85	9.64	111.6
15	Fred Gladding F. Gladding	98	22	76	23	.489	233	0	3.68	132	0	0	264.0	282	108	126	11	92	14	163	28	1,152	16	4.50	3.14	1.43	0.38	11.5	8.0	1.42	.300	4.30	104	3.25	95	9.61	5.2
16	Bob Knepper B. Knepper	94	93	1	100	.482	284	267	3.66	946	41	18	1738.0	1,748	706	812	148	521	27	5	40	7,315	36	4.90	2.70	1.82	0.77	12.9	7.1	1.31	.282	4.20	105	3.70	107	9.05	-56.1
17	Wandy Rodriguez W. Rodriguez	80	80	0	84	.488	227	218	4.04	1,093	2	2	1306.2	1,295	587	664	147	454	45	1	31	5,577	34	7.53	3.13	2.41	1.01	19.6	8.1	1.34	.299	4.57	98	4.03	96	8.92	28.1
18	Jose Valverde J. Valverde	79	10	69	5	.667	126	0	2.93	139	0	0	126.0	102	41	43	15	44	4	116	7	522	4	9.93	3.14	3.16	1.07	26.6	8.4	1.16	.272	3.07	70	3.59	83	7.29	10.1
19	Doug Jones D. Jones	77	15	62	18	.455	151	0	3.02	159	0	0	197.0	198	66	75	12	38	10	130	11	821	5	7.26	1.74	4.18	0.55	19.4	4.6	1.20	.309	3.43	82	2.77	77	9.05	17.6
20	Framber Valdez F. Valdez	76	76	0	45	.628	173	151	3.26	968	9	3	991.2	820	359	395	78	358	55	7	1	4,095	54	8.79	3.25	2.70	0.71	23.6	8.7	1.19	.281	3.58	79	3.48	84	7.44	72.7
21	Dallas Keuchel D. Keuchel	76	76	0	63	.547	192	183	3.66	945	12	4	1189.1	1,144	484	521	115	343	21	2	7	4,937	44	7.15	2.60	2.76	0.87	19.1	6.9	1.25	.293	3.94	92	3.71	92	8.66	45.3
22	Mike Hampton M. Hampton	76	76	0	50	.603	216	172	3.59	767	13	6	1138.0	1,140	454	525	88	419	23	7	16	4,844	35	6.07	3.31	1.83	0.70	15.8	8.6	1.37	.297	4.15	89	3.94	96	9.02	21
23	Justin Verlander J. Verlander	73	73	0	28	.723	130	130	2.71	962	3	2	810.1	589	244	261	106	155	31	0	0	3,166	16	10.68	1.72	6.21	1.18	30.4	4.9	0.92	.253	2.90	65	3.18	76	6.54	92.7
24	Darryl Kile D. Kile	71	71	0	65	.522	209	182	3.79	973	16	6	1200.0	1,128	505	580	89	562	72	7	27	5,241	58	7.30	4.22	1.73	0.67	18.6	10.7	1.41	.293	4.35	99	3.96	103	8.46	-14.6
25	Josh Hader J. Hader	68	13	55	9	.591	105	0	3.10	161	0	0	107.1	62	37	41	17	32	3	93	0	416	6	13.50	2.68	5.03	1.43	38.7	7.7	0.88	.222	3.44	78	3.16	78	5.20	10.4