Joe Niekro has won the most career games for the Astros, with 144 wins.

Interpreted as:

most regular-season wins with astros by a pitcher

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Joe Niekro J. Niekro	144	116	.554	397	301	3.22	1,178	82	21	9	2270.0	2,052	811	934	139	818	41	41	33	9,490	128	4.67	3.24	1.44	0.55	12.4	8.6	1.26	.262	3.70	95	3.59	104	8.14	-46
2	Roy Oswalt R. Oswalt	143	82	.636	303	291	3.24	1,593	19	7	0	1932.1	1,865	696	747	167	446	68	5	32	7,976	23	7.42	2.08	3.57	0.78	20.0	5.6	1.20	.298	3.48	76	3.35	77	8.69	217.7
3	Larry Dierker L. Dierker	137	117	.539	345	320	3.28	1,487	106	25	1	2294.1	2,090	837	927	177	695	48	9	43	9,492	102	5.83	2.73	2.14	0.69	15.7	7.3	1.21	.270	3.64	96	3.20	96	8.20	33.2
4	Mike Scott M. Scott	110	81	.576	263	259	3.30	1,318	42	21	0	1704.0	1,444	625	694	144	505	30	3	45	6,989	35	6.96	2.67	2.61	0.76	18.9	7.2	1.14	.260	3.67	94	3.26	93	7.63	45.3
5	J.R. Richard	107	71	.601	238	221	3.15	1,493	76	19	0	1606.0	1,227	562	625	73	770	17	3	15	6,674	92	8.37	4.32	1.94	0.41	22.4	11.5	1.24	.267	3.50	92	2.85	82	6.88	114.7
6	Nolan Ryan N. Ryan	106	94	.530	282	282	3.13	1,866	38	13	0	1854.2	1,441	645	739	111	796	44	0	31	7,716	104	9.05	3.86	2.34	0.54	24.2	10.3	1.21	.271	3.59	91	2.86	83	6.99	124.4
7	Don Wilson D. Wilson	104	92	.531	266	245	3.15	1,283	78	20	2	1748.1	1,479	611	698	119	640	47	10	32	7,305	77	6.60	3.29	2.00	0.61	17.6	8.8	1.21	.261	3.59	92	3.09	92	7.61	43.7
8	Shane Reynolds S. Reynolds	103	86	.545	274	248	3.95	1,309	20	7	0	1622.1	1,738	712	785	171	358	33	5	27	6,865	38	7.26	1.99	3.66	0.95	19.1	5.2	1.29	.314	4.35	95	3.58	85	9.64	111.6
9	Bob Knepper B. Knepper	93	100	.482	284	267	3.66	946	41	18	1	1738.0	1,748	706	812	148	521	27	5	40	7,315	36	4.90	2.70	1.82	0.77	12.9	7.1	1.31	.282	4.20	105	3.70	107	9.05	-56.1
10	Wandy Rodriguez W. Rodriguez	80	84	.488	227	218	4.04	1,093	2	2	0	1306.2	1,295	587	664	147	454	45	1	31	5,577	34	7.53	3.13	2.41	1.01	19.6	8.1	1.34	.299	4.57	98	4.03	96	8.92	28.1
11	Ken Forsch K. Forsch	78	81	.491	421	153	3.18	815	36	9	50	1493.2	1,439	528	587	96	428	26	171	58	6,213	36	4.91	2.58	1.90	0.58	13.1	6.9	1.25	.277	3.54	92	3.25	94	8.67	30.3
12	Dallas Keuchel D. Keuchel	76	63	.547	192	183	3.66	945	12	4	0	1189.1	1,144	484	521	115	343	21	2	7	4,937	44	7.15	2.60	2.76	0.87	19.1	6.9	1.25	.293	3.94	92	3.71	92	8.66	45.3
13	Mike Hampton M. Hampton	76	50	.603	216	172	3.59	767	13	6	0	1138.0	1,140	454	525	88	419	23	7	16	4,844	35	6.07	3.31	1.83	0.70	15.8	8.6	1.37	.297	4.15	89	3.94	96	9.02	21
14	Justin Verlander J. Verlander	73	28	.723	130	130	2.71	962	3	2	0	810.1	589	244	261	106	155	31	0	0	3,166	16	10.68	1.72	6.21	1.18	30.4	4.9	0.92	.253	2.90	65	3.18	76	6.54	92.7
15	Framber Valdez F. Valdez	71	45	.612	167	145	3.32	925	8	3	0	951.2	793	351	387	77	340	54	7	1	3,934	51	8.75	3.22	2.72	0.73	23.5	8.6	1.19	.282	3.66	80	3.52	85	7.50	66.6
16	Darryl Kile D. Kile	71	65	.522	209	182	3.79	973	16	6	0	1200.0	1,128	505	580	89	562	72	7	27	5,241	58	7.30	4.22	1.73	0.67	18.6	10.7	1.41	.293	4.35	99	3.96	103	8.46	-14.6
17	Jim Deshaies J. Deshaies	61	59	.508	181	178	3.67	731	14	6	0	1102.0	960	449	479	113	423	17	0	36	4,599	16	5.97	3.45	1.73	0.92	15.9	9.2	1.25	.256	3.91	103	4.00	113	7.84	-64.1
18	Collin McHugh C. McHugh	58	35	.624	195	110	3.63	743	1	0	0	753.1	699	304	320	82	219	33	26	4	3,145	24	8.88	2.62	3.39	0.98	23.6	7.0	1.22	.298	3.82	90	3.59	88	8.35	42.2
19	Wade Miller W. Miller	58	39	.598	127	123	3.87	659	5	1	0	768.0	699	330	362	91	306	23	2	14	3,246	18	7.72	3.59	2.15	1.07	20.3	9.4	1.31	.281	4.24	87	4.14	94	8.19	23.8
20	Dave Smith D. Smith	53	47	.530	563	1	2.53	529	0	0	199	762.0	646	214	254	28	260	12	400	57	3,145	27	6.25	3.07	2.03	0.33	16.8	8.3	1.19	.267	3.00	74	2.90	84	7.63	47.3
21	Turk Farrell T. Farrell	53	64	.453	181	132	3.42	694	41	5	8	1015.0	947	386	432	95	212	14	29	21	4,148	15	6.15	1.88	3.27	0.84	16.7	5.1	1.14	.272	3.83	100	3.07	92	8.40	29.4
22	Mark Portugal M. Portugal	52	30	.634	135	123	3.34	535	6	3	1	782.1	711	290	322	64	281	13	4	15	3,262	23	6.15	3.23	1.90	0.74	16.4	8.6	1.27	.273	3.70	93	3.67	102	8.18	-9.4
23	Lance McCullers Jr. L. McCullers Jr.	49	33	.598	133	130	3.53	806	1	0	0	726.2	613	285	308	58	303	41	0	4	3,062	48	9.98	3.75	2.66	0.72	26.3	9.9	1.26	.299	3.81	86	3.39	81	7.59	64.3
24	Danny Darwin D. Darwin	47	35	.573	220	81	3.21	543	10	1	12	769.0	694	274	299	66	201	24	52	37	3,171	8	6.36	2.35	2.70	0.77	17.1	6.3	1.16	.269	3.50	89	3.40	94	8.12	15.2
25	Dave Roberts D. Roberts	47	44	.516	140	121	3.69	403	34	11	4	843.2	889	346	373	55	257	9	9	17	3,604	20	4.30	2.74	1.57	0.59	11.2	7.1	1.36	.290	3.98	107	3.36	98	9.48	5.2