Randy Johnson, Nolan Ryan and Toad Ramsey were tied for playing the most seasons with 350+ strikeouts, with 2 seasons.

Interpreted as:

most years 350 or more strikeouts pitcher

	NAME	SEAS	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Randy Johnson R. Johnson	2	736	70	38	15	.717	69	2.49	15	4	0	521.1	388	144	160	49	141	27	1	5	2,073	12	12.71	2.43	5.22	0.85	35.5	6.8	1.01	.303	2.76	54	2.45	54	6.70	121.1
2	Nolan Ryan N. Ryan	2	750	83	43	32	.573	80	2.88	52	7	1	658.2	459	211	240	36	364	16	3	5	2,747	24	10.25	4.97	2.06	0.49	27.3	13.3	1.25	.268	3.28	83	2.73	77	6.27	61.1
3	Toad Ramsey T. Ramsey	2	854	132	75	54	.581	131	2.93	127	3	0	1149.2	991	374	655	12	374	16	1		4,907	81	6.69	2.93	2.28	0.09	17.4	7.6	1.19	.269	5.13	75	2.89	76	7.76	118.9
4	Sandy Koufax S. Koufax	1	382	43	26	8	.765	41	2.04	27	8	2	335.2	216	76	90	26	71	5	2	4	1,297	11	10.24	1.90	5.38	0.70	29.5	5.5	0.86	.234	2.41	63	1.93	61	5.79	47.9
5	Mark Baldwin M. Baldwin	1	368	63	27	34	.443	59	3.61	54	6	1	513.2	458	206	358	9	274	20	4		2,275	83	6.45	4.80	1.34	0.16	16.2	12.0	1.43	.280	6.27	100	3.52	98	8.02	-3
6	Matt Kilroy M. Kilroy	1	513	68	29	34	.460	68	3.37	66	5	0	583.0	476	218	350	10	182	19	0		2,469	61	7.92	2.81	2.82	0.15	20.8	7.4	1.13	.267	5.40	100	2.60	77	7.35	47
7	Charlie Buffinton C. Buffinton	1	417	67	48	16	.750	67	2.15	63	8	0	587.0	506	140	225	15	76		0		2,383	24	6.39	1.17	5.49	0.23	17.5	3.2	0.99		3.45	74	2.57	77	7.76	46.8
8	Hugh Daily H. Daily	1	483	58	28	28	.500	58	2.43	56	5	0	500.2	446	135	268	11	72		0		2,076	50	8.68	1.29	6.71	0.20	23.3	3.5	1.03		4.82	81	2.06	79	8.02	27.4
9	Pud Galvin P. Galvin	1	369	72	46	22	.676	72	1.99	71	12	0	636.1	566	141	254	23	63		0		2,554	16	5.22	0.89	5.86	0.33	14.4	2.5	0.99		3.59	64	2.88	82	8.01	50.9
10	Guy Hecker G. Hecker	1	385	75	52	20	.722	73	1.80	72	6	0	670.2	526	134	230	4	56	16	2		2,649	27	5.17	0.75	6.88	0.05	14.5	2.1	0.87	.239	3.09	57	2.53	80	7.06	43
11	Old Hoss Radbourn O. Hoss Radbourn	1	441	75	59	12	.831	73	1.38	73	11	2	678.2	528	104	216	18	98		2		2,672	34	5.85	1.30	4.50	0.24	16.5	3.7	0.92		2.86	48	2.75	84	7.00	31.9
12	Dupee Shaw D. Shaw	1	451	67	30	33	.476	66	2.30	60	5	0	543.1	446	139	281	9	109		1		2,244	24	7.47	1.81	4.14	0.15	20.1	4.9	1.02		4.65	77	2.43	81	7.39	29
13	Bill Sweeney B. Sweeney	1	374	62	40	21	.656	60	2.59	58	4	0	538.0	522	155	294	13	74		2		2,270	43	6.26	1.24	5.05	0.22	16.5	3.3	1.11		4.92	80	2.61	93	8.73	19.5
14	Tim Keefe T. Keefe	1	359	68	41	27	.603	68	2.41	68	5	0	619.0	488	166	244	6	108		0		2,517	27	5.22	1.57	3.32	0.09	14.3	4.3	0.96		3.55	72	2.74	82	7.10	45.1