Nolan Ryan had a 106-94 record with an ERA of 3.13 and 1,866 strikeouts in 282 appearances for the Astros in his career.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 1980 |  HOU | 35 | 11 | 10 | .524 | 35 | 3.35 | 200 | 4 | 2 | 0 | 233.2 | 205 | 87 | 100 | 10 | 98 | 3 | 0 | 1 | 982 | 10 | 7.70 | 3.77 | 2.04 | 0.39 | 20.4 | 10.0 | 1.30 | .291 | 3.85 | 99 | 2.89 | 83 | 7.90 | 15.1 |
| 2 | | N. Ryan | 1981 | HOU | 21 | 11 | 5 | .688 | 21 | 1.69 | 140 | 5 | 3 | 0 | 149.0 | 99 | 28 | 34 | 2 | 68 | 1 | 0 | 1 | 605 | 16 | 8.46 | 4.11 | 2.06 | 0.12 | 23.1 | 11.2 | 1.12 | .246 | 2.05 | 52 | 2.28 | 70 | 5.98 | 16.5 |
| 3 | | N. Ryan | 1982 | HOU | 35 | 16 | 12 | .571 | 35 | 3.16 | 245 | 10 | 3 | 0 | 250.1 | 196 | 88 | 100 | 20 | 109 | 8 | 0 | 3 | 1,050 | 18 | 8.81 | 3.92 | 2.25 | 0.72 | 23.3 | 10.4 | 1.22 | .263 | 3.60 | 93 | 3.19 | 95 | 7.05 | 4 |
| 4 | | N. Ryan | 1983 | HOU | 29 | 14 | 9 | .609 | 29 | 2.98 | 183 | 5 | 2 | 0 | 196.1 | 134 | 65 | 74 | 9 | 101 | 4 | 0 | 3 | 804 | 5 | 8.39 | 4.63 | 1.81 | 0.41 | 22.8 | 12.6 | 1.20 | .247 | 3.39 | 87 | 3.08 | 88 | 6.14 | 8.7 |
| 5 | | N. Ryan | 1984 | HOU | 30 | 12 | 11 | .522 | 30 | 3.04 | 197 | 5 | 2 | 0 | 183.2 | 143 | 62 | 78 | 12 | 69 | 4 | 0 | 2 | 760 | 6 | 9.65 | 3.38 | 2.86 | 0.59 | 25.9 | 9.1 | 1.15 | .274 | 3.82 | 88 | 2.66 | 79 | 7.01 | 15.1 |
| 6 | | N. Ryan | 1985 | HOU | 35 | 10 | 12 | .455 | 35 | 3.80 | 209 | 4 | 0 | 0 | 232.0 | 205 | 98 | 108 | 12 | 95 | 9 | 0 | 8 | 983 | 14 | 8.11 | 3.69 | 2.20 | 0.47 | 21.3 | 9.7 | 1.29 | .293 | 4.19 | 111 | 2.89 | 84 | 7.95 | 14.2 |
| 7 | | N. Ryan | 1986 | HOU | 30 | 12 | 8 | .600 | 30 | 3.34 | 194 | 1 | 0 | 0 | 178.0 | 119 | 66 | 72 | 14 | 82 | 4 | 0 | 5 | 729 | 15 | 9.81 | 4.15 | 2.37 | 0.71 | 26.6 | 11.2 | 1.13 | .241 | 3.64 | 95 | 3.05 | 87 | 6.02 | 9.2 |
| 8 | | N. Ryan | 1987 | HOU | 34 | 8 | 16 | .333 | 34 | 2.76 | 270 | 0 | 0 | 0 | 211.2 | 154 | 65 | 75 | 14 | 87 | 4 | 0 | 2 | 873 | 10 | 11.48 | 3.70 | 3.10 | 0.60 | 30.9 | 10.0 | 1.14 | .281 | 3.19 | 70 | 2.46 | 63 | 6.55 | 34.5 |
| 9 | | N. Ryan | 1988 | HOU | 33 | 12 | 11 | .522 | 33 | 3.52 | 228 | 4 | 1 | 0 | 220.0 | 186 | 86 | 98 | 18 | 87 | 7 | 0 | 6 | 930 | 10 | 9.33 | 3.56 | 2.62 | 0.74 | 24.5 | 9.4 | 1.24 | .285 | 4.01 | 105 | 3.03 | 91 | 7.61 | 7.1 |
| Total | 282 | 106 | 94 | .530 | 282 | 3.13 | 1,866 | 38 | 13 | 0 | 1854.2 | 1,441 | 645 | 739 | 111 | 796 | 44 | 0 | 31 | 7,716 | 104 | 9.05 | 3.86 | 2.34 | 0.54 | 24.2 | 10.3 | 1.21 | .271 | 3.59 | 91 | 2.86 | 83 | 6.99 | 124.4 |
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