The San Diego Padres had their most runs in a game against the Giants on May 23, 1970, with 17 runs.

Interpreted as:

padres highest run in a regular-season game total vs giants

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Padres	17	5/23/1970	SDP	@	SFG	W 17-16	63	21	3	0	5	15	12	1	11	0	0	79	39	8	3	0	2	0	.333	.447	.619	1.066
2	Padres	16	4/29/2023	SDP	vs	SFG	W 16-11	41	17	5	0	6	14	10	0	11	3	0	51	40	11	0	0	1	0	.415	.529	.976	1.505
3	Padres	16	4/5/1983	SDP	@	SFG	W 16-13	43	17	5	0	1	15	10	0	5	1	1	54	25	6	0	1	2	0	.395	.500	.581	1.081
4	Padres	15	7/2/1995	SDP	@	SFG	W 15-3	39	14	3	0	2	13	10	0	6	0	0	50	23	5	0	1	3	1	.359	.480	.590	1.070
5	Padres	13	3/31/2024	SDP	vs	SFG	W 13-4	40	16	6	0	2	12	4	0	7	0	0	44	28	8	0	0	0	1	.400	.455	.700	1.155
6	Padres	13	8/10/2022	SDP	vs	SFG	W 13-7	40	16	3	0	2	12	3	0	9	0	0	43	25	5	0	0	0	0	.400	.442	.625	1.067
7	Padres	13	9/13/1991	SDP	@	SFG	W 13-2	41	15	2	0	1	12	7	1	4	0	0	50	20	3	1	0	0	0	.366	.469	.488	.957
8	Padres	13	4/23/1990	SDP	vs	SFG	W 13-3	40	17	4	0	2	13	5	0	4	1	0	45	27	6	0	0	0	0	.425	.489	.675	1.164
9	Padres	13	4/19/1982	SDP	vs	SFG	W 13-6	43	24	5	0	1	12	1	0	2	2	1	45	32	6	1	0	0	3	.558	.568	.744	1.312
10	Padres	12	7/30/2020	SDP	@	SFG	W 12-7	44	14	4	1	1	11	2	1	15	3	0	48	23	6	1	0	0	0	.318	.362	.523	.884
11	Padres	12	7/21/2017	SDP	@	SFG	W 12-9	50	20	3	3	2	12	6	0	8	0	0	57	35	8	1	0	0	1	.400	.464	.700	1.164
12	Padres	12	4/29/2017	SDP	@	SFG	W 12-4	41	14	1	0	2	12	4	0	15	2	1	45	21	3	0	0	0	0	.341	.400	.512	.912
13	Padres	12	9/20/1997	SDP	vs	SFG	W 12-2	36	12	3	0	1	12	9	0	8	0	0	46	18	4	1	0	0	0	.333	.467	.500	.967
14	Padres	12	10/3/1980	SDP	@	SFG	W 12-0	37	15	2	1	1	12	3	1	4	3	0	43	22	4	0	2	1	3	.405	.442	.595	1.036
15	Padres	12	9/9/1980	SDP	vs	SFG	W 12-5	36	13	3	0	3	11	12	0	6	0	1	48	25	6	0	0	0	0	.361	.521	.694	1.215
16	Padres	12	5/30/1977	SDP	@	SFG	W 12-8	37	12	4	1	1	11	6	0	5	0	1	43	21	6	0	0	2	1	.324	.419	.568	.986
17	Padres	12	5/17/1976	SDP	@	SFG	W 12-2	41	16	0	2	0	9	5	0	4	1	0	48	20	2	1	1	0	1	.390	.447	.488	.935
18	Padres	11	5/9/2021	SDP	@	SFG	W 11-1	43	16	4	1	2	10	3	0	8	0	0	47	28	7	0	1	1	0	.372	.404	.651	1.055
19	Padres	11	7/16/2011	SDP	vs	SFG	W 11-3	34	10	0	0	2	10	6	0	10	3	1	40	16	2	0	0	0	0	.294	.400	.471	.871
20	Padres	11	9/11/2008	SDP	vs	SFG	W 11-3	40	17	4	0	4	11	4	0	6	0	0	44	33	8	0	0	1	1	.425	.477	.825	1.302
21	Padres	11	9/26/2007	SDP	@	SFG	W 11-3	43	17	5	0	1	11	3	0	7	0	0	46	25	6	0	0	1	0	.395	.435	.581	1.016
22	Padres	11	4/21/2004	SDP	@	SFG	W 11-0	42	17	1	1	2	10	4	0	2	0	0	47	26	4	0	1	0	2	.405	.447	.619	1.066
23	Padres	11	4/9/2003	SDP	@	SFG	L 11-15	35	15	2	1	2	11	5	1	1	0	0	44	25	5	2	1	0	4	.429	.500	.714	1.214
24	Padres	11	9/18/1999	SDP	vs	SFG	W 11-5	37	13	2	0	2	11	4	2	7	3	0	44	21	4	0	1	0	0	.351	.432	.568	.999
25	Padres	11	4/10/1999	SDP	@	SFG	W 11-1	39	12	2	0	3	11	3	0	10	0	0	44	23	5	2	0	0	0	.308	.357	.590	.947