Joe Musgrove won the most games for the Padres in 2021, with 11 wins.

	NAME	W	SEASON	TM	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Joe Musgrove J. Musgrove	11	2021	SDP	9	.550	32	31	3.18	203	2	2	0	181.1	142	64	68	22	54	18	1	3	748	3	10.08	2.68	3.76	1.09	27.1	7.2	1.08	.266	3.38	81	3.69	88	7.05	10.2
2	Yu Darvish Y. Darvish	8	2021	SDP	11	.421	30	30	4.22	199	0	0	0	166.1	138	78	81	28	44	8	0	1	681	9	10.77	2.38	4.52	1.52	29.2	6.5	1.09	.274	4.38	107	3.90	93	7.47	5.6
3	Blake Snell B. Snell	7	2021	SDP	6	.538	27	27	4.20	170	0	0	0	128.2	101	60	61	16	69	3	0	1	550	7	11.89	4.83	2.46	1.12	30.9	12.5	1.32	.291	4.27	106	3.82	91	7.06	5.5
4	Chris Paddack C. Paddack	7	2021	SDP	7	.500	23	22	5.07	99	0	0	0	108.1	115	61	67	15	22	1	0	1	459	2	8.22	1.83	4.50	1.25	21.6	4.8	1.26	.311	5.57	128	3.77	90	9.55	5.1
5	Tim Hill T. Hill	6	2021	SDP	6	.500	78	0	3.62	56	0	0	1	59.2	51	24	34	9	23	6	10	5	255	1	8.45	3.47	2.43	1.36	22.0	9.0	1.24	.261	5.13	92	4.70	112	7.69	-3.4
6	Craig Stammen C. Stammen	6	2021	SDP	3	.667	67	4	3.06	83	0	0	1	88.1	79	30	31	13	13	3	4	1	355	3	8.46	1.32	6.38	1.32	23.4	3.7	1.04	.272	3.16	77	3.74	89	8.05	4.5
7	Mark Melancon M. Melancon	4	2021	SDP	3	.571	64	0	2.23	59	0	0	39	64.2	54	16	21	4	25	1	53	4	265	3	8.21	3.48	2.36	0.56	22.3	9.4	1.22	.284	2.92	56	3.35	80	7.52	6.1
8	Emilio Pagán E. Pagán	4	2021	SDP	3	.571	67	0	4.83	69	0	0	0	63.1	56	34	35	16	18	2	10	0	263	0	9.81	2.56	3.83	2.27	26.2	6.8	1.17	.253	4.97	123	5.21	124	7.96	-7.3
9	Ryan Weathers R. Weathers	4	2021	SDP	7	.364	30	18	5.32	72	0	0	1	94.2	101	56	57	20	30	3	1	1	401	2	6.85	2.85	2.40	1.90	18.0	7.5	1.38	.293	5.42	135	5.43	129	9.60	-13.2
10	Austin Adams A. Adams	3	2021	SDP	2	.600	65	0	4.10	76	0	0	0	52.2	28	24	28	1	35	24	18	2	241	4	12.99	5.98	2.17	0.17	31.5	14.5	1.20	.257	4.78	104	3.88	93	4.78	1.8
11	Nabil Crismatt N. Crismatt	3	2021	SDP	1	.750	45	0	3.76	71	0	0	0	81.1	87	34	40	10	24	8	14	2	351	3	7.86	2.66	2.96	1.11	20.2	6.8	1.36	.324	4.43	95	4.20	100	9.63	0
12	Miguel Díaz M. Díaz	3	2021	SDP	1	.750	25	2	3.64	46	0	0	1	42.0	31	17	19	8	19	0	10	0	172	0	9.86	4.07	2.42	1.71	26.7	11.0	1.19	.232	4.07	92	4.81	114	6.64	-2.9
13	Pierce Johnson P. Johnson	3	2021	SDP	4	.429	63	2	3.22	77	0	0	0	58.2	47	21	21	6	27	1	7	3	244	6	11.81	4.14	2.85	0.92	31.6	11.1	1.26	.308	3.22	82	3.30	79	7.21	5.9
14	Keone Kela K. Kela	2	2021	SDP	2	.500	12	0	5.06	13	0	0	0	10.2	11	6	8	3	3	0	2	0	48	2	10.97	2.53	4.33	2.53	27.1	6.3	1.31	.276	6.75	128	5.22	124	9.28	-1.2
15	Dinelson Lamet D. Lamet	2	2021	SDP	4	.333	22	9	4.40	57	0	0	0	47.0	48	23	24	6	22	2	1	0	209	3	10.91	4.21	2.59	1.15	27.3	10.5	1.49	.344	4.60	112	3.93	94	9.19	1.4
16	Ross Detwiler R. Detwiler	1	2021	SDP	0	1.000	7	0	2.57	6	0	0	0	7.0	3	2	2	2	5	1	4	1	29	1	7.71	6.43	1.20	2.57	20.7	17.2	1.14	.067	2.57	65	7.73	184	3.86	-2.8
17	Daniel Hudson D. Hudson	1	2021	SDP	2	.333	23	0	5.21	27	0	0	0	19.0	17	11	13	4	9	0	6	1	83	2	12.79	4.26	3.00	1.89	32.5	10.8	1.37	.302	6.16	132	4.48	107	8.05	-0.6
18	Aaron Northcraft A. Northcraft	1	2021	SDP	0	1.000	5	0	2.25	5	0	0	0	8.0	5	2	2	1	8	0	3	0	34	0	5.63	9.00	0.63	1.13	14.7	23.5	1.63	.200	2.25	57	6.54	156	5.63	-2.1
19	Drew Pomeranz D. Pomeranz	1	2021	SDP	0	1.000	27	0	1.75	30	0	0	0	25.2	19	5	6	2	10	0	2	1	102	1	10.52	3.51	3.00	0.70	29.4	9.8	1.13	.283	2.10	44	3.01	72	6.66	3.4
20	Nick Ramirez N. Ramirez	1	2021	SDP	1	.500	13	0	5.75	14	0	0	0	20.1	23	13	15	2	7	0	5	2	91	0	6.20	3.10	2.00	0.89	15.4	7.7	1.48	.309	6.64	146	4.10	98	10.18	0.2
21	Reiss Knehr R. Knehr	1	2021	SDP	2	.333	12	5	4.97	20	0	0	0	29.0	23	16	16	2	20	2	1	1	129	3	6.21	6.21	1.00	0.62	15.5	15.5	1.48	.247	4.97	126	4.96	118	7.14	-2.5