The Pittsburgh Pirates had their most runs in a game versus the Reds on April 27, 1912, with 23 runs.

Interpreted as:

pirates most runs in a regular-season game vs reds

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Pirates	23	4/27/1912	PIT	vs	CIN	W 23-4	43	27	5	3	0	20	5	0	1	8		51	38	8	3				.628	.667	.884	1.550
2	Pirates	19	8/21/1968	PIT	@	CIN	W 19-1	47	23	3	1	3	18	6	0	10	2	0	54	37	7	1	0	0	1	.489	.547	.787	1.334
3	Pirates	18	5/2/1925	PIT	vs	CIN	W 18-3	39	15	4	3	2	18	8	0	4	1	0	48	31	9	1				.385	.489	.795	1.284
4	Alleghenys	17	8/7/1890	PTN	@	CIN	L 17-23
5	Pirates	16	7/4/1951	PIT	vs	CIN	W 16-4	34	17	2	0	3	15	4	0	1	0	0	39	28	5	1		0	0	.500	.553	.824	1.376
6	Pirates	16	9/25/1948	PIT	vs	CIN	W 16-6	43	20	0	1	0	15	6	1	2	0	0	50	22	1	0			1	.465	.540	.512	1.052
7	Pirates	16	9/21/1934	PIT	vs	CIN	W 16-3	43	20	1	1	0	13	6	0	1	1	0	49	23	2	0			0	.465	.531	.535	1.065
8	Pirates	16	8/28/1930	PIT	vs	CIN	W 16-12	37	16	2	2	1	14	3	1	2	2	0	45	25	5	4				.432	.488	.676	1.163
9	Pirates	16	10/6/1912	PIT	@	CIN	W 16-6	42	19	2	3	1	14	5	0	8	2		51	30	6	4				.452	.511	.714	1.225
10	Pirates	15	4/22/1923	PIT	@	CIN	W 15-9	43	17	2	1	1	14	7	1	2	0	0	52	24	4	1				.395	.490	.558	1.048
11	Pirates	15	6/23/1918	PIT	@	CIN	W 15-1	46	19	2	1	0	12	4	0	1	3		51	23	3	1				.413	.460	.500	.960
12	Pirates	15	9/8/1913	PIT	@	CIN	W 15-2	39	15	2	1	0	13	5	0	1	3		49	19	3	5				.385	.455	.487	.942
13	Pirates	15	8/1/1894	PIT	vs	CIN	W 15-5
14	Pirates	15	4/30/1894	PIT	@	CIN	W 15-6
15	Alleghenys	15	9/5/1883	PIT	vs	CIN	W 15-9
16	Pirates	14	8/24/2019	PIT	vs	CIN	W 14-0	33	10	2	0	2	13	4	2	5	0	0	40	18	4	1	0	0	0	.303	.410	.545	.956
17	Pirates	14	4/6/2018	PIT	vs	CIN	W 14-3	38	15	6	1	0	13	6	1	5	2	0	45	23	7	0	0	0	0	.395	.489	.605	1.094
18	Pirates	14	5/27/2007	PIT	@	CIN	W 14-10	41	18	4	0	2	14	2	0	9	2	0	45	28	6	0	2	0	2	.439	.444	.683	1.127
19	Pirates	14	7/24/2004	PIT	vs	CIN	W 14-4	39	15	6	0	0	14	4	2	4	1	0	48	21	6	2	1	0	0	.385	.457	.538	.995
20	Pirates	14	6/27/2004	PIT	@	CIN	W 14-4	42	18	5	1	1	13	8	1	8	1	1	52	28	7	0	1	1	0	.429	.519	.667	1.186
21	Pirates	14	7/4/2001	PIT	@	CIN	W 14-3	43	19	2	0	5	13	5	0	11	1	0	50	36	7	2	0	0	1	.442	.500	.837	1.337
22	Pirates	14	8/21/1998	PIT	vs	CIN	W 14-2	39	17	5	1	2	14	6	0	4	0	0	46	30	8	1	0	0	1	.436	.511	.769	1.280
23	Pirates	14	8/13/1974	PIT	@	CIN	W 14-3	45	21	1	0	2	13	2	0	1	0	0	50	28	3	2	1	1	0	.467	.479	.622	1.101
24	Pirates	14	6/1/1974	PIT	@	CIN	W 14-1	43	18	5	1	3	14	7	0	3	0	0	51	34	9	0	1	0	2	.419	.490	.791	1.281
25	Pirates	14	8/12/1966	PIT	@	CIN	W 14-11	51	13	1	0	6	12	10	1	11	1	0	62	32	7	0	0	3	2	.255	.387	.627	1.015