7 pitchers are tied for the most games pitched when allowing 5+ HR, with 2 games. The first three are Joe Ryan, Hunter Greene and Clay Buchholz.

Interpreted as:

pitcher 5 or more home runs allowed most regular-season game

	NAME	G	HR	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Joe Ryan J. Ryan	2	10	0	2	.000	2	18.78	12	0	0	0	7.2	17	16	16	2	0	0	0	42	0	14.09	2.35	6.00	11.74	28.6	4.8	2.48	.389	18.78	19.96
2	Hunter Greene H. Greene	2	10	0	2	.000	2	25.41	11	0	0	0	5.2	19	16	17	4	0	0	0	42	2	17.47	6.35	2.75	15.88	26.2	9.5	4.06	.529	27.00	30.18
3	Clay Buchholz C. Buchholz	2	10	0	2	.000	2	9.82	6	0	0	0	11.0	17	12	13	3	0	0	0	53	1	4.91	2.45	2.00	8.18	11.3	5.7	1.82	.206	10.64	13.91
4	Josh Beckett J. Beckett	2	10	0	2	.000	2	10.66	8	0	0	0	12.2	16	15	15	1	0	0	0	56	0	5.68	0.71	8.00	7.11	14.3	1.8	1.34	.162	10.66	11.37
5	Jeff Weaver J. Weaver	2	10	0	1	.000	2	13.91	7	0	0	0	11.0	20	17	17	3	0	0	0	54	0	5.73	2.45	2.33	8.18	13.0	5.6	2.09	.294	13.91	16.36
6	Tim Wakefield T. Wakefield	2	11	1	0	1.000	2	9.82	8	0	0	0	11.0	14	12	12	2	0	0	0	50	0	6.55	1.64	4.00	9.00	16.0	4.0	1.45	.103	9.82	11.45
7	Pat Hentgen P. Hentgen	2	10	0	2	.000	2	10.13	7	0	0	0	16.0	24	18	18	2	1	0	0	73	1	3.94	1.13	3.50	5.63	9.6	2.7	1.63	.264	10.13	13.50
8	Kyle Gibson K. Gibson	1	5	0	1	.000	1	22.09	2	0	0	0	3.2	11	9	9	2	0	0	0	24	0	4.91	4.91	1.00	12.27	8.3	8.3	3.55	.400	22.09	27.00
9	Bowden Francis B. Francis	1	5	0	1	.000	1	21.00	1	0	0	0	3.0	8	7	7	0	0	0	0	17	0	3.00	0.00		15.00	5.9	0.0	2.67	.273	21.00	24.00
10	Nestor Cortes N. Cortes	1	5	0	1	.000	1	36.00	2	0	0	0	2.0	6	8	8	5	0	0	0	17	0	9.00	22.50	0.40	22.50	11.8	29.4	5.50	.200	36.00	27.00
11	Carson Spiers C. Spiers	1	5	0	1	.000	1	18.69	3	0	0	0	4.1	13	9	10	2	1	0	0	28	0	6.23	4.15	1.50	10.38	10.7	7.1	3.46	.471	20.77	27.00
12	Kutter Crawford K. Crawford	1	5	0	1	.000	1	10.80	2	0	0	0	5.0	7	6	6	0	0	0	0	22	0	3.60	0.00		9.00	9.1	0.0	1.40	.133	10.80	12.60
13	Martín Pérez M. Pérez	1	5	0	1	.000	1	16.20	4	0	0	0	5.0	11	9	9	1	0	0	0	26	0	7.20	1.80	4.00	9.00	15.4	3.8	2.40	.375	16.20	19.80
14	Tony Gonsolin T. Gonsolin	1	5	0	1	.000	1	27.00	2	0	0	0	3.1	8	10	10	4	0	0	0	22	0	5.40	10.80	0.50	13.50	9.1	18.2	3.60	.273	27.00	21.60
15	Josh Fleming J. Fleming	1	5	0	0		1	12.00	3	0	0	0	6.0	12	8	10	2	0	0	1	32	0	4.50	3.00	1.50	7.50	9.4	6.3	2.33	.318	15.00	18.00
16	José Suarez J. Suarez	1	5	0	0		1	12.60	5	0	0	0	5.0	8	7	7	2	0	0	0	23	0	9.00	3.60	2.50	9.00	21.7	8.7	2.00	.273	12.60	14.40
17	Michael Kopech M. Kopech	1	5	0	1	.000	1	13.50	5	0	0	0	4.2	8	7	7	3	0	0	0	25	0	9.64	5.79	1.67	9.64	20.0	12.0	2.36	.250	13.50	15.43
18	Tommy Romero T. Romero	1	5	0	1	.000	1	14.73	2	0	0	0	3.2	8	6	8	4	0	0	0	23	0	4.91	9.82	0.50	12.27	8.7	17.4	3.27	.250	19.64	19.64
19	Hunter Gaddis H. Gaddis	1	5	0	1	.000	1	15.75	3	0	0	0	4.0	8	7	7	1	0	0	0	21	0	6.75	2.25	3.00	11.25	14.3	4.8	2.25	.250	15.75	18.00
20	Matt Swarmer M. Swarmer	1	6	0	1	.000	1	10.80	4	0	0	0	5.0	7	6	6	0	0	0	0	22	0	7.20	0.00		10.80	18.2	0.0	1.40	.083	10.80	12.60
21	Gerrit Cole G. Cole	1	5	0	0		1	27.00	3	0	0	0	2.1	8	7	7	2	0	0	0	17	0	11.57	7.71	1.50	19.29	17.6	11.8	4.29	.429	27.00	30.86
22	Bruce Zimmermann B. Zimmermann	1	5	0	1	.000	1	13.50	2	0	0	0	4.0	8	6	6	1	0	0	0	20	1	4.50	2.25	2.00	11.25	10.0	5.0	2.25	.250	13.50	18.00
23	Nathan Eovaldi N. Eovaldi	1	5	0	1	.000	1	32.40	0	0	0	0	1.2	8	6	9	0	0	0	0	14	0	0.00	0.00		27.00	0.0	0.0	4.80	.333	48.60	43.20
24	Brady Singer B. Singer	1	5	0	1	.000	1	11.57	7	0	0	0	4.2	7	6	6	2	0	0	0	23	0	13.50	3.86	3.50	9.64	30.4	8.7	1.93	.222	11.57	13.50
25	Kyle Freeland K. Freeland	1	5	0	1	.000	1	18.00	2	0	0	0	4.0	8	8	9	1	0	0	0	22	0	4.50	2.25	2.00	11.25	9.1	4.5	2.25	.214	20.25	18.00