Between the 2005 and 2010 seasons, Johan Santana struck out the most hitters, with 1,214 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Johan Santana J. Santana	1,214	188	90	51	.638	188	2.92	12	7	0	1284.1	1,090	417	452	138	308	18	0	11	5,193	31	8.51	2.16	3.94	0.97	23.4	5.9	1.09	.271	3.17	69	3.38	80	7.64	120.2
2	CC Sabathia	1,187	196	103	53	.660	196	3.26	25	9	0	1351.0	1,234	489	542	113	343	45	0	19	5,531	26	7.91	2.28	3.46	0.75	21.5	6.2	1.17	.292	3.61	74	3.30	76	8.22	158
3	Dan Haren D. Haren	1,176	203	85	64	.570	203	3.55	11	2	0	1343.0	1,291	530	580	158	285	34	0	24	5,546	62	7.88	1.91	4.13	1.06	21.2	5.1	1.17	.291	3.89	82	3.60	83	8.65	107.9
4	Javier Vazquez J. Vazquez	1,148	194	74	71	.510	188	4.25	10	1	0	1220.0	1,176	576	607	164	322	44	4	16	5,105	35	8.47	2.38	3.57	1.21	22.5	6.3	1.23	.295	4.48	95	3.88	87	8.68	81.3
5	A.J. Burnett	1,063	179	73	62	.541	178	4.09	11	3	0	1125.1	1,061	511	564	118	445	65	1	10	4,823	67	8.50	3.56	2.39	0.94	22.0	9.2	1.34	.301	4.51	93	3.94	89	8.49	58.9
6	Felix Hernandez F. Hernandez	1,042	172	71	53	.573	172	3.20	13	4	0	1154.2	1,057	410	465	97	357	35	0	14	4,787	60	8.12	2.78	2.92	0.76	21.8	7.5	1.22	.295	3.62	76	3.42	80	8.24	109.1
7	Jake Peavy J. Peavy	1,040	156	69	50	.580	156	3.28	8	4	0	1011.0	842	369	383	92	307	30	0	22	4,125	21	9.26	2.73	3.39	0.82	25.2	7.4	1.14	.282	3.41	81	3.24	76	7.50	114.5
8	Roy Halladay R. Halladay	1,012	181	102	47	.685	180	2.91	43	13	0	1322.2	1,243	427	466	109	204	38	0	14	5,299	20	6.89	1.39	4.96	0.74	19.1	3.8	1.09	.288	3.17	66	3.21	73	8.46	169.2
9	Josh Beckett J. Beckett	1,005	172	86	48	.642	172	4.14	8	3	0	1098.1	1,055	505	539	130	306	46	0	8	4,604	30	8.24	2.51	3.28	1.07	21.8	6.6	1.24	.297	4.42	92	3.78	89	8.64	59.5
10	Roy Oswalt R. Oswalt	1,000	196	87	56	.608	193	3.22	15	5	0	1276.0	1,228	457	483	111	290	44	1	21	5,264	14	7.05	2.05	3.45	0.78	19.0	5.5	1.19	.292	3.41	76	3.46	80	8.66	124.6
11	John Lackey J. Lackey	993	183	83	49	.629	183	3.65	10	5	0	1205.1	1,201	489	539	106	354	60	0	13	5,096	57	7.41	2.64	2.81	0.79	19.5	6.9	1.29	.306	4.02	83	3.64	85	8.97	90.6
12	Carlos Zambrano C. Zambrano	988	194	82	45	.646	178	3.61	5	2	0	1141.1	965	458	497	99	521	52	2	18	4,851	37	7.79	4.11	1.90	0.78	20.4	10.7	1.30	.271	3.92	81	4.02	91	7.61	47.6
13	Aaron Harang A. Harang	974	180	61	68	.473	176	4.15	12	5	0	1136.0	1,202	524	559	153	290	34	1	25	4,828	41	7.72	2.30	3.36	1.21	20.2	6.0	1.31	.311	4.43	95	4.01	90	9.52	58.4
14	Justin Verlander J. Verlander	965	165	83	52	.615	165	3.81	10	3	0	1064.1	987	450	482	94	353	52	0	17	4,483	48	8.16	2.98	2.73	0.79	21.5	7.9	1.26	.296	4.08	86	3.60	82	8.35	93.5
15	Scott Kazmir S. Kazmir	952	171	64	58	.525	171	4.09	1	1	0	987.0	930	448	489	109	450	41	0	11	4,285	47	8.68	4.10	2.12	0.99	22.2	10.5	1.40	.300	4.46	96	4.11	96	8.48	22.1
16	Ted Lilly T. Lilly	931	182	79	62	.560	182	4.00	1	1	0	1090.1	998	485	513	165	338	24	0	17	4,562	25	7.68	2.79	2.75	1.36	20.4	7.4	1.23	.268	4.23	91	4.37	100	8.24	-1.4
17	Tim Lincecum T. Lincecum	907	123	56	27	.675	122	3.04	7	4	0	811.0	666	274	295	51	293	19	0	15	3,348	47	10.07	3.25	3.10	0.57	27.1	8.8	1.18	.296	3.27	73	2.85	69	7.39	117.1
18	Matt Cain M. Cain	906	171	57	62	.479	170	3.45	12	4	0	1095.2	925	420	441	99	410	25	1	24	4,546	46	7.44	3.37	2.21	0.81	19.9	9.0	1.22	.266	3.62	81	3.83	92	7.60	43.4
19	Cole Hamels C. Hamels	897	149	60	45	.571	149	3.53	7	4	0	945.1	864	371	396	122	248	20	0	24	3,885	14	8.54	2.36	3.62	1.16	23.1	6.4	1.18	.286	3.77	82	3.76	87	8.23	61.1
20	Andy Pettitte A. Pettitte	897	191	85	56	.603	188	3.78	2	1	0	1179.2	1,213	496	551	112	352	20	1	18	4,971	18	6.84	2.69	2.55	0.85	18.0	7.1	1.33	.307	4.20	86	3.77	85	9.25	85.2
21	Barry Zito B. Zito	877	202	70	80	.467	200	4.23	2	0	0	1217.1	1,127	572	611	134	538	49	1	34	5,232	25	6.48	3.98	1.63	0.99	16.8	10.3	1.37	.273	4.52	100	4.54	107	8.33	-42
22	Cliff Lee C. Lee	874	178	85	49	.634	174	3.64	20	5	0	1167.1	1,184	472	518	113	241	26	1	9	4,866	26	6.74	1.86	3.63	0.87	18.0	5.0	1.22	.297	3.99	84	3.55	83	9.13	95.1
23	Brett Myers B. Myers	873	197	58	46	.558	141	3.91	7	1	21	966.1	931	420	449	136	312	28	38	16	4,088	17	8.13	2.91	2.80	1.27	21.4	7.6	1.29	.290	4.18	91	4.17	96	8.67	19.9
24	Ervin Santana E. Santana	856	173	76	55	.580	170	4.39	9	5	0	1069.0	1,072	522	558	138	342	57	1	15	4,569	41	7.21	2.88	2.50	1.16	18.7	7.5	1.32	.294	4.70	102	4.31	100	9.03	-2.4
25	Bronson Arroyo B. Arroyo	851	204	84	70	.545	201	4.06	10	3	0	1292.2	1,288	583	635	170	373	53	1	29	5,465	23	5.92	2.60	2.28	1.18	15.6	6.8	1.28	.278	4.42	92	4.49	102	8.97	-9.7