pitcher with most 5 strikeout games in career

Nolan Ryan had the most games pitched when striking out 5+ batters, with 596 games.

Interpreted as:

pitcher with most 5 or more strikeout regular-season games in career

	NAME	G	SO	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	596	5,196	286	196	.593	594	2.61	218	60	0	4522.1	3,001	1,313	1,511	237	2,169	121	1	60	18,516	222	10.34	4.32	2.40	0.47	28.1	11.7	1.14	.256	3.01	5.97
2	Roger Clemens R. Clemens	529	4,151	291	114	.719	529	2.67	111	43	0	3869.1	3,049	1,146	1,255	258	1,159	120	0	45	15,628	100	9.66	2.70	3.58	0.60	26.6	7.4	1.09	.281	2.92	7.09
3	Randy Johnson R. Johnson	489	4,522	269	114	.702	486	2.74	97	37	1	3523.0	2,645	1,071	1,207	319	1,150	152	2	31	14,210	81	11.55	2.94	3.93	0.81	31.8	8.1	1.08	.288	3.08	6.76
4	Steve Carlton S. Carlton	440	3,365	254	118	.683	440	2.58	214	40	0	3510.0	2,832	1,005	1,121	220	1,157	30	0	96	14,218	123	8.63	2.97	2.91	0.56	23.7	8.1	1.14	.277	2.87	7.26
5	Justin Verlander J. Verlander	411	3,118	227	92	.712	411	2.69	22	8	0	2743.0	2,104	820	879	260	683	86	0	18	10,931	79	10.23	2.24	4.57	0.85	28.5	6.2	1.02	.272	2.88	6.90
6	Bert Blyleven B. Blyleven	411	2,936	209	119	.637	411	2.49	202	54	0	3293.0	2,715	912	1,025	226	841	101	0	40	13,229	67	8.02	2.30	3.49	0.62	22.2	6.4	1.08	.273	2.80	7.42
7	Max Scherzer M. Scherzer	390	3,223	200	82	.709	389	2.79	12	5	0	2535.0	1,914	786	837	281	628	88	0	18	10,058	61	11.44	2.23	5.13	1.00	32.0	6.2	1.00	.280	2.97	6.80
8	Tom Seaver T. Seaver	389	2,934	218	97	.692	389	2.28	180	44	0	3121.0	2,343	789	870	223	839	40	0	67	12,365	68	8.46	2.42	3.50	0.64	23.7	6.8	1.02	.255	2.51	6.76
9	Don Sutton D. Sutton	381	2,573	200	104	.658	381	2.52	134	43	0	2954.0	2,336	827	916	202	692	42	0	53	11,788	66	7.84	2.11	3.72	0.62	21.8	5.9	1.03	.258	2.79	7.12
10	CC Sabathia	358	2,504	188	89	.679	358	3.06	33	12	0	2428.1	2,082	825	907	226	691	81	0	30	9,903	42	9.28	2.56	3.62	0.84	25.3	7.0	1.14	.290	3.36	7.72
11	Gaylord Perry G. Perry	357	2,510	197	111	.640	351	2.28	216	36	0	2981.2	2,385	755	889	188	725	58	1	73	11,873	79	7.58	2.19	3.46	0.57	21.1	6.1	1.04	.262	2.68	7.20
12	Clayton Kershaw C. Kershaw	356	2,757	196	70	.737	356	2.19	22	13	0	2365.2	1,693	576	626	187	547	34	0	18	9,198	85	10.49	2.08	5.04	0.71	30.0	5.9	0.95	.265	2.38	6.44
13	Greg Maddux G. Maddux	354	2,316	190	89	.681	354	2.42	74	24	0	2606.0	2,193	701	794	138	458	68	0	85	10,346	38	8.00	1.58	5.06	0.48	22.4	4.4	1.02	.279	2.74	7.57
14	Walter Johnson W. Johnson	352	2,470	234	105	.690	339	1.12	312	74	1	3142.2	2,282		756	37	660	117	13		12,214	94	7.07	1.89	3.74	0.11	20.2	5.4	0.94	.251	2.17	6.54
15	Bob Gibson B. Gibson	347	2,676	202	109	.650	344	2.44	221	51	0	2905.0	2,279	787	893	173	899	71	1	77	11,773	73	8.29	2.79	2.98	0.54	22.7	7.6	1.09	.265	2.77	7.06
16	Fergie Jenkins F. Jenkins	339	2,405	204	101	.669	336	2.58	203	40	0	2773.0	2,248	794	894	262	533	56	2	64	11,008	43	7.81	1.73	4.51	0.85	21.8	4.8	1.00	.256	2.90	7.30
17	Phil Niekro P. Niekro	339	2,202	171	107	.615	336	2.62	168	29	1	2704.2	2,222	786	924	215	839	65	2	36	11,027	116	7.33	2.79	2.62	0.72	20.0	7.6	1.13	.260	3.07	7.39
18	Curt Schilling C. Schilling	330	2,640	175	90	.660	328	3.06	73	17	0	2417.0	2,069	823	862	235	473	40	0	25	9,662	53	9.83	1.76	5.58	0.88	27.3	4.9	1.05	.292	3.21	7.70
19	Zack Greinke Z. Greinke	329	2,301	166	65	.719	327	2.61	11	4	0	2150.0	1,775	624	670	181	418	44	0	10	8,500	63	9.63	1.75	5.50	0.76	27.1	4.9	1.02	.287	2.80	7.43
20	John Smoltz J. Smoltz	329	2,370	162	90	.643	329	2.78	47	15	0	2353.2	1,918	728	799	182	631	39	0	56	9,474	93	9.06	2.41	3.76	0.70	25.0	6.7	1.08	.278	3.06	7.33
21	Pedro Martinez P. Martinez	326	2,778	181	70	.721	325	2.43	45	17	0	2304.2	1,669	623	692	177	559	101	1	19	9,086	50	10.85	2.18	4.97	0.69	30.6	6.2	0.97	.273	2.70	6.52
22	Mike Mussina M. Mussina	317	2,209	180	71	.717	317	2.98	45	20	0	2247.1	1,932	743	794	199	442	35	0	14	8,939	39	8.85	1.77	5.00	0.80	24.7	4.9	1.06	.286	3.18	7.74
23	Cole Hamels C. Hamels	316	2,250	134	75	.641	316	2.74	15	6	0	2142.1	1,756	652	703	233	540	67	0	32	8,592	37	9.45	2.27	4.17	0.98	26.2	6.3	1.07	.277	2.95	7.38
24	Mickey Lolich M. Lolich	300	2,210	158	92	.632	299	2.72	153	35	0	2370.0	1,964	717	807	200	656	65	1	30	9,614	76	8.39	2.49	3.37	0.76	23.0	6.8	1.11	.272	3.06	7.46
25	Felix Hernandez F. Hernandez	297	2,163	136	76	.642	297	2.58	22	10	0	2063.0	1,664	591	655	162	540	70	0	10	8,259	115	9.44	2.36	4.01	0.71	26.2	6.5	1.07	.282	2.86	7.26