Between the 1955 and 1966 seasons, Bob Friend pitched the most innings in the NL, with 2890.2 innings.

	NAME	IP	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Bob Friend B. Friend	2890.2	454	168	176	.488	400	3.33	1,457	142	32	8	2,955	1,068	1,228	223	618	39	35	114	12,026	39	4.54	1.92	2.36	0.69	12.1	5.1	1.24	.282	3.82	89	3.18	86	9.20	163.5
2	Don Drysdale D. Drysdale	2848.1	437	177	134	.569	384	3.00	2,111	145	37	6	2,543	950	1,089	241	726	132	34	94	11,725	72	6.67	2.29	2.91	0.76	18.0	6.2	1.15	.270	3.44	82	3.05	86	8.04	163
3	Warren Spahn W. Spahn	2810.2	414	197	135	.593	363	3.20	1,299	193	30	14	2,671	1,000	1,103	268	691	26	40	60	11,532	38	4.16	2.21	1.88	0.86	11.3	6.0	1.20	.260	3.53	90	3.58	102	8.55	-23.4
4	Larry Jackson L. Jackson	2757.1	484	168	151	.527	358	3.49	1,443	126	31	20	2,735	1,068	1,208	233	710	58	72	80	11,518	51	4.71	2.32	2.03	0.76	12.5	6.2	1.25	.276	3.94	89	3.41	89	8.93	127.8
5	Lew Burdette L. Burdette	2413.2	419	159	112	.587	319	3.77	854	134	28	10	2,542	1,011	1,135	249	446	42	49	61	10,034	16	3.18	1.66	1.91	0.93	8.5	4.4	1.24	.272	4.23	104	3.73	105	9.48	-54
6	Sandy Koufax S. Koufax	2324.1	397	165	87	.655	314	2.76	2,396	137	40	9	1,754	713	806	204	817	18	44	48	9,497	87	9.28	3.16	2.93	0.79	25.2	8.6	1.11	.256	3.12	75	2.69	75	6.79	226.6
7	Bob Buhl B. Buhl	2319.1	393	151	117	.563	337	3.55	1,127	101	16	3	2,190	915	1,045	222	965	32	25	52	9,877	62	4.37	3.74	1.17	0.86	11.4	9.8	1.36	.261	4.06	97	4.07	113	8.50	-132.8
8	Vern Law V. Law	2171.1	364	138	110	.556	305	3.51	894	104	26	8	2,264	847	959	223	423	26	39	65	9,015	29	3.71	1.75	2.11	0.92	9.9	4.7	1.24	.274	3.97	94	3.64	99	9.38	11.6
9	Curt Simmons C. Simmons	2014.1	343	115	108	.516	288	3.55	925	83	20	1	2,077	795	935	168	524	35	29	55	8,486	24	4.13	2.34	1.77	0.75	10.9	6.2	1.29	.279	4.18	91	3.50	92	9.28	75.1
10	Bob Purkey B. Purkey	1983.1	350	126	107	.541	265	3.71	755	92	13	8	2,025	817	920	192	448	64	46	41	8,318	35	3.43	2.03	1.69	0.87	9.1	5.4	1.25	.267	4.17	95	3.80	100	9.19	7.8
11	Robin Roberts R. Roberts	1921.1	288	107	121	.469	258	3.97	976	122	12	10	2,015	848	949	257	310	17	22	45	7,979	12	4.57	1.45	3.15	1.20	12.2	3.9	1.21	.274	4.45	103	3.70	97	9.44	25.5
12	Jack Sanford J. Sanford	1841.2	307	119	88	.575	272	3.61	1,081	76	14	4	1,687	739	841	154	679	40	16	47	7,791	53	5.28	3.32	1.59	0.75	13.9	8.7	1.28	.263	4.11	97	3.61	99	8.24	4.8
13	Joe Nuxhall J. Nuxhall	1768.0	381	108	89	.548	238	3.76	1,100	70	18	15	1,759	738	814	169	531	49	51	42	7,452	29	5.60	2.70	2.07	0.86	14.8	7.1	1.30	.284	4.14	96	3.46	90	8.95	80.1
14	Johnny Podres J. Podres	1762.2	304	116	93	.555	271	3.57	1,170	65	20	6	1,736	700	776	186	553	23	19	62	7,415	51	5.97	2.82	2.12	0.95	15.8	7.5	1.30	.283	3.96	94	3.54	94	8.86	45.6
15	Bob Gibson B. Gibson	1728.2	256	112	81	.580	218	3.13	1,435	100	23	4	1,461	602	687	137	664	56	17	45	7,246	58	7.47	3.46	2.16	0.71	19.8	9.2	1.23	.267	3.58	81	3.17	84	7.61	115.1
16	Juan Marichal J. Marichal	1722.0	227	130	58	.691	220	2.66	1,251	122	30	2	1,427	508	586	167	361	17	7	32	6,890	24	6.54	1.89	3.47	0.87	18.2	5.2	1.04	.247	3.06	73	3.02	86	7.46	89.8
17	Don Cardwell D. Cardwell	1624.1	293	80	103	.437	236	4.02	974	59	12	6	1,534	726	815	185	516	72	28	48	6,846	47	5.40	2.86	1.89	1.03	14.2	7.5	1.26	.265	4.52	106	3.90	106	8.50	-34.6
18	Dick Ellsworth D. Ellsworth	1613.1	254	84	110	.433	236	3.70	905	71	6	2	1,666	663	770	156	454	25	7	45	6,834	54	5.05	2.53	1.99	0.87	13.2	6.6	1.31	.285	4.30	97	3.58	97	9.29	19.2
19	Jim O'Toole J. O'Toole	1561.0	255	94	81	.537	228	3.59	1,002	57	17	4	1,492	623	709	115	528	25	11	38	6,591	41	5.78	3.04	1.90	0.66	15.2	8.0	1.29	.280	4.09	94	3.29	88	8.60	76.5
20	Harvey Haddix H. Haddix	1557.0	294	88	82	.518	212	3.83	1,086	64	11	5	1,557	663	735	177	399	30	36	63	6,536	37	6.28	2.31	2.72	1.02	16.6	6.1	1.26	.285	4.25	99	3.39	88	9.00	80.3
21	Roger Craig R. Craig	1536.1	368	74	98	.430	186	3.83	803	58	7	19	1,528	653	763	186	522	35	79	48	6,545	42	4.70	3.06	1.54	1.09	12.3	8.0	1.33	.268	4.47	98	4.13	107	8.95	-37.9
22	Joey Jay J. Jay	1518.1	292	97	91	.516	201	3.76	982	62	15	7	1,433	635	701	151	586	35	44	34	6,458	52	5.82	3.47	1.68	0.90	15.2	9.1	1.33	.273	4.16	101	3.78	103	8.49	-20
23	Sam Jones S. Jones	1507.0	269	98	93	.513	211	3.51	1,265	75	17	8	1,279	588	678	131	740	54	35	36	6,467	38	7.55	4.42	1.71	0.78	19.6	11.4	1.34	.268	4.05	90	3.50	90	7.64	62.9
24	Turk Farrell T. Farrell	1444.0	433	89	95	.484	133	3.50	1,002	41	5	56	1,366	561	631	131	387	22	202	64	5,996	36	6.25	2.41	2.59	0.82	16.7	6.5	1.21	.277	3.93	97	3.18	91	8.51	50.5
25	Chris Short C. Short	1379.0	300	87	72	.547	177	3.37	988	59	16	11	1,302	517	590	104	466	36	52	43	5,792	52	6.45	3.04	2.12	0.68	17.1	8.0	1.28	.285	3.85	93	3.19	91	8.50	45.9