Between the 1903 and 1916 seasons, Christy Mathewson pitched the most innings in the NL, with 4134.1 innings.

	NAME	IP	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Christy Mathewson C. Mathewson	4134.1	555	339	151	.692	480	2.09	2,107	368	66	30	3,648	959	1,339	82	654	32	65	16,253	74	4.59	1.42	3.22	0.18	13.0	4.0	1.04	.267	2.91	74	2.19	75	7.94	335.7
2	Mordecai Brown M. Brown	2703.1	411	208	111	.652	281	1.93	1,167	236	50	45	2,284	579	863	33	548	51	121	10,523	48	3.89	1.82	2.13	0.11	11.1	5.2	1.05	.258	2.87	67	2.37	82	7.60	151.9
3	Red Ames R. Ames	2696.1	437	156	136	.534	319	2.57	1,549	180	25	30	2,401	769	1,107	37	897	55	88	11,004	142	5.17	2.99	1.73	0.12	14.1	8.2	1.22	.279	3.70	91	2.52	86	8.01	120.8
4	Vic Willis V. Willis	2391.0	310	140	130	.519	285	2.57	960	224	32	6	2,188	684	941	32	662	60	25	9,605	48	3.61	2.49	1.45	0.12	10.0	6.9	1.19	.273	3.54	94	2.64	94	8.24	39.6
5	Nap Rucker N. Rucker	2375.1	336	134	134	.500	274	2.42	1,217	186	38	14	2,089	639	823	41	701	73	58	9,441	43	4.61	2.66	1.74	0.16	12.9	7.4	1.17	.276	3.12	86	2.60	90	7.92	73.7
6	Ed Reulbach E. Reulbach	2340.0	361	161	95	.629	268	2.28	1,011	177	36	12	1,863	594	786	30	808	103	75	9,357	41	3.89	3.11	1.25	0.12	10.8	8.6	1.14	.248	3.02	80	2.88	99	7.17	2.4
7	Bob Ewing B. Ewing	2183.1	276	119	112	.515	252	2.47	954	195	19	4	1,971	598	873	30	567	52	24	8,647	42	3.93	2.34	1.68	0.12	11.0	6.6	1.16	.276	3.60	86	2.51	86	8.12	107.6
8	Grover Alexander G. Alexander	2104.0	284	160	75	.681	233	2.18	1,203	185	53	15	1,765	509	681	42	499	48	47	8,358	18	5.15	2.13	2.41	0.18	14.4	6.0	1.08	.262	2.91	69	2.44	77	7.55	171.3
9	Hooks Wiltse H. Wiltse	2053.0	339	136	85	.615	222	2.48	948	151	27	28	1,843	565	765	53	491	38	100	8,187	40	4.16	2.15	1.93	0.23	11.6	6.0	1.14	.269	3.35	89	2.56	90	8.08	67.4
10	Slim Sallee S. Sallee	2017.0	332	115	111	.509	223	2.60	687	130	19	26	1,927	582	803	46	477	39	85	8,237	11	3.07	2.13	1.44	0.21	8.3	5.8	1.19	.269	3.58	90	2.87	96	8.60	26.7
11	Joe McGinnity J. McGinnity	1998.1	281	143	80	.641	221	2.40	720	170	25	21	1,815	533	722	33	432	75	50	8,068	16	3.24	1.95	1.67	0.15	8.9	5.4	1.12	.262	3.25	87	2.69	94	8.17	40.5
12	Bob Harmon B. Harmon	1971.2	305	105	126	.455	231	3.36	627	138	15	12	1,890	737	927	41	750	38	56	8,205	39	2.86	3.42	0.84	0.19	7.6	9.1	1.34	.274	4.23	112	3.36	110	8.63	-69.9
13	Howie Camnitz H. Camnitz	1803.1	286	119	87	.578	201	2.66	827	117	19	14	1,577	533	714	32	555	57	71	7,249	33	4.13	2.77	1.49	0.16	11.4	7.7	1.18	.267	3.56	90	2.78	93	7.87	36.3
14	Babe Adams B. Adams	1778.2	271	113	84	.574	215	2.58	692	123	24	5	1,620	509	655	34	299	35	44	7,018	16	3.50	1.51	2.31	0.17	9.9	4.3	1.08	.266	3.31	89	2.54	85	8.20	90.2
15	Rube Marquard R. Marquard	1775.2	281	118	84	.584	213	2.75	1,017	114	18	18	1,618	542	704	51	473	27	46	7,190	55	5.15	2.40	2.15	0.26	14.1	6.6	1.18	.279	3.57	94	2.61	86	8.20	81.3
16	Tully Sparks T. Sparks	1690.0	223	95	94	.503	197	2.44	586	149	18	7	1,537	458	645	21	370	52	23	6,708	14	3.12	1.97	1.58	0.11	8.7	5.5	1.13	.267	3.43	91	2.59	93	8.19	33.2
17	Lefty Leifield L. Leifield	1670.0	258	116	87	.571	201	2.42	573	129	29	7	1,499	449	619	22	507	79	42	6,715	16	3.09	2.73	1.13	0.12	8.5	7.6	1.20	.267	3.34	87	2.93	102	8.08	-6.3
18	Harry McIntire H. McIntire	1650.0	237	71	117	.378	188	3.22	626	140	17	7	1,555	590	778	34	539	96	40	6,714	14	3.41	2.94	1.16	0.19	9.3	8.0	1.27	.281	4.24	121	3.01	112	8.48	-62.7
19	Sam Leever S. Leever	1618.0	253	128	52	.711	182	2.24	459	138	26	8	1,449	403	566	16	342	53	58	6,410	20	2.55	1.90	1.34	0.09	7.2	5.3	1.11	.259	3.15	81	2.69	95	8.06	28.8
20	George McQuillan G. McQuillan	1553.1	268	85	88	.491	172	2.38	583	105	17	13	1,357	411	568	23	397	30	74	6,160	16	3.38	2.30	1.47	0.13	9.5	6.4	1.13	.260	3.29	87	2.59	93	7.86	29
21	Orval Overall O. Overall	1535.1	218	108	71	.603	182	2.26	935	133	30	12	1,232	385	520	16	551	45	30	6,145	57	5.48	3.23	1.70	0.09	15.2	9.0	1.16	.264	3.05	81	2.39	85	7.22	72.4
22	Jake Weimer J. Weimer	1472.2	191	97	69	.584	180	2.23	657	143	21	2	1,227	365	511	14	493	73	9	5,971	26	4.02	3.01	1.33	0.09	11.0	8.3	1.17	.256	3.12	81	2.81	98	7.50	8.7
23	Buster Brown B. Brown	1451.2	234	51	103	.331	165	3.21	501	107	10	4	1,368	517	715	36	631	59	55	6,029	53	3.11	3.91	0.79	0.22	8.3	10.5	1.38	.277	4.43	105	3.52	115	8.48	-61.1
24	Lefty Tyler L. Tyler	1448.2	215	78	80	.494	171	3.15	729	112	18	5	1,297	507	681	41	592	53	35	6,048	44	4.53	3.68	1.23	0.25	12.1	9.8	1.30	.271	4.23	100	3.24	102	8.06	-4.3
25	Deacon Phillippe D. Phillippe	1439.0	224	106	58	.646	156	2.58	561	121	18	9	1,374	413	561	16	193	31	57	5,709	28	3.51	1.21	2.91	0.10	9.8	3.4	1.09	.277	3.51	92	2.27	79	8.59	101