Matt Kilroy has struck out the most batters in a season, with 513 strikeouts in his rookie season in 1886.

	NAME	SO	SEASON	TM	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Matt Kilroy M. Kilroy	513	1886	BAL	68	29	34	.460	68	3.37	66	5	0	583.0	476	218	350	10	182	19	0		2,469	61	7.92	2.81	2.82	0.15	20.8	7.4	1.13	.267	5.40	100	2.60	77	7.35	47
2	Toad Ramsey T. Ramsey	499	1886	LOU	67	38	27	.585	67	2.45	66	3	0	588.2	447	160	297	3	207	12	0		2,477	35	7.63	3.16	2.41	0.05	20.1	8.4	1.11	.253	4.54	71	2.59	76	6.83	54.7
3	Hugh Daily H. Daily	483	1884	TOT	58	28	28	.500	58	2.43	56	5	0	500.2	446	135	268	11	72		0		2,076	50	8.68	1.29	6.71	0.20	23.3	3.5	1.03		4.82	81	2.06	79	8.02	27.4
4	Dupee Shaw D. Shaw	451	1884	TOT	67	30	33	.476	66	2.30	60	5	0	543.1	446	139	281	9	109		1		2,244	24	7.47	1.81	4.14	0.15	20.1	4.9	1.02		4.65	77	2.43	81	7.39	29
5	Old Hoss Radbourn O. Hoss Radbourn	441	1884	PRO	75	59	12	.831	73	1.38	73	11	2	678.2	528	104	216	18	98		2		2,672	34	5.85	1.30	4.50	0.24	16.5	3.7	0.92		2.86	48	2.75	84	7.00	31.9
6	Charlie Buffinton C. Buffinton	417	1884	BSN	67	48	16	.750	67	2.15	63	8	0	587.0	506	140	225	15	76		0		2,383	24	6.39	1.17	5.49	0.23	17.5	3.2	0.99		3.45	74	2.57	77	7.76	46.8
7	Guy Hecker G. Hecker	385	1884	LOU	75	52	20	.722	73	1.80	72	6	0	670.2	526	134	230	4	56	16	2		2,649	27	5.17	0.75	6.88	0.05	14.5	2.1	0.87	.239	3.09	57	2.53	80	7.06	43
8	Nolan Ryan N. Ryan	383	1973	CAL	41	21	16	.568	39	2.87	26	4	1	326.0	238	104	113	18	162	7	2	2	1,355	15	10.57	4.47	2.36	0.50	28.3	12.0	1.23	.280	3.12	80	2.48	69	6.57	40.9
9	Sandy Koufax S. Koufax	382	1965	LAD	43	26	8	.765	41	2.04	27	8	2	335.2	216	76	90	26	71	5	2	4	1,297	11	10.24	1.90	5.38	0.70	29.5	5.5	0.86	.234	2.41	63	1.93	61	5.79	47.9
10	Bill Sweeney B. Sweeney	374	1884	BLU	62	40	21	.656	60	2.59	58	4	0	538.0	522	155	294	13	74		2		2,270	43	6.26	1.24	5.05	0.22	16.5	3.3	1.11		4.92	80	2.61	93	8.73	19.5
11	Randy Johnson R. Johnson	372	2001	ARI	35	21	6	.778	34	2.49	3	2	0	249.2	181	69	74	19	71	18	1	2	994	8	13.41	2.56	5.24	0.68	37.4	7.1	1.01	.315	2.67	55	2.12	48	6.52	63.9
12	Pud Galvin P. Galvin	369	1884	BUF	72	46	22	.676	72	1.99	71	12	0	636.1	566	141	254	23	63		0		2,554	16	5.22	0.89	5.86	0.33	14.4	2.5	0.99		3.59	64	2.88	82	8.01	50.9
13	Mark Baldwin M. Baldwin	368	1889	COL	63	27	34	.443	59	3.61	54	6	1	513.2	458	206	358	9	274	20	4		2,275	83	6.45	4.80	1.34	0.16	16.2	12.0	1.43	.280	6.27	100	3.52	98	8.02	-3
14	Nolan Ryan N. Ryan	367	1974	CAL	42	22	16	.579	41	2.89	26	3	0	332.2	221	107	127	18	202	9	1	3	1,392	9	9.93	5.46	1.82	0.49	26.4	14.5	1.27	.255	3.44	85	2.97	84	5.98	20.2
15	Randy Johnson R. Johnson	364	1999	ARI	35	17	9	.654	35	2.48	12	2	0	271.2	207	75	86	30	70	9	0	3	1,079	4	12.06	2.32	5.20	0.99	33.7	6.5	1.02	.292	2.85	53	2.75	59	6.86	57.2
16	Tim Keefe T. Keefe	359	1883	NYM	68	41	27	.603	68	2.41	68	5	0	619.0	488	166	244	6	108		0		2,517	27	5.22	1.57	3.32	0.09	14.3	4.3	0.96		3.55	72	2.74	82	7.10	45.1
17	Toad Ramsey T. Ramsey	355	1887	LOU	65	37	27	.578	64	3.43	61	0	0	561.0	544	214	358	9	167	16	1		2,430	46	5.70	2.68	2.13	0.14	14.6	6.9	1.27	.284	5.74	78	3.20	76	8.73	64.2
18	Rube Waddell R. Waddell	349	1904	PHA	46	25	19	.568	46	1.62	39	8	0	383.0	307	69	109	5	91	14	0		1,496	8	8.20	2.14	3.84	0.12	23.3	6.1	1.04	.291	2.56	61	1.59	62	7.21	41.5
19	Bob Feller B. Feller	348	1946	CLE	48	26	15	.634	42	2.18	36	10	4	371.1	277	90	101	11	153	3	5		1,512	3	8.43	3.71	2.27	0.27	23.0	10.1	1.16	.267	2.45	65	2.16	65	6.71	48.3
20	Randy Johnson R. Johnson	347	2000	ARI	35	19	7	.731	35	2.64	8	3	0	248.2	202	73	89	23	76	6	0	1	1,001	5	12.56	2.75	4.57	0.83	34.7	7.6	1.12	.326	3.22	56	2.53	53	7.31	61.1
21	Hardie Henderson H. Henderson	346	1884	BLA	52	27	23	.540	52	2.62	50	4	0	439.1	382	128	235	9	116	16	0		1,900	45	7.09	2.38	2.98	0.18	18.2	6.1	1.13	.264	4.81	81	2.87	89	7.83	16.5
22	Mickey Welch M. Welch	345	1884	NYG	65	39	21	.650	65	2.50	62	4	0	557.1	528	155	275	12	146		1		2,370	39	5.57	2.36	2.36	0.19	14.6	6.2	1.21		4.44	85	3.10	92	8.53	14.6
23	Jim Whitney J. Whitney	345	1883	BSN	62	37	21	.638	56	2.24	54	1	2	514.0	492	128	258	7	35		5		2,101	37	6.04	0.61	9.86	0.12	16.4	1.7	1.03		4.52	74	2.29	75	8.61	39.8
24	Jim McCormick J. McCormick	343	1884	TOT	66	40	25	.615	65	2.37	63	10	0	569.0	508	150	263	19	89		2		2,336	15	5.43	1.41	3.85	0.30	14.7	3.8	1.05		4.16	80	2.97	94	8.04	9.6
25	Nolan Ryan N. Ryan	341	1977	CAL	37	19	16	.543	37	2.77	22	4	0	299.0	198	92	110	12	204	9	0	7	1,272	21	10.26	6.14	1.67	0.36	26.8	16.0	1.34	.263	3.31	72	3.11	79	5.96	27.9