Between the 2001 and 2021 seasons, Albert Pujols smashed the most homers, with 679 homers.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	wRC	WRAA	wOBA	wRC+	BRAA
1	Albert Pujols A. Pujols	679	2,971	11,114	1,872	3,301	672	16	2,150	1,345	113	1,349	116	41	12,690	6,042	1,367	1	117	315	413	.297	.375	.544	.919	2174	665.5	.385	141	652.9
2	David Ortiz D. Ortiz	521	2,167	7,878	1,302	2,262	573	18	1,653	1,216	33	1,566	15	9	9,211	4,434	1,112	2	82	204	212	.287	.381	.563	.944	1638	550.4	.396	143	481.6
3	Alex Rodriguez A. Rodriguez	507	1,994	7,440	1,394	2,149	354	18	1,491	1,028	145	1,671	196	40	8,692	4,060	879	0	79	88	198	.289	.382	.546	.928	1543	501.9	.394	142	455
4	Miguel Cabrera M. Cabrera	502	2,587	9,625	1,505	2,987	597	17	1,804	1,199	69	1,930	39	21	10,993	5,124	1,116	5	95	235	342	.310	.387	.532	.920	1904	603.1	.389	143	563.6
5	Adam Dunn A. Dunn	462	2,001	6,883	1,097	1,631	334	10	1,168	1,317	86	2,379	63	25	8,328	3,371	806	2	40	122	100	.237	.364	.490	.854	1285	297.9	.367	123	240
6	Nelson Cruz N. Cruz	449	1,882	6,910	1,031	1,913	351	14	1,238	683	80	1,751	79	32	7,731	3,639	814	2	56	76	161	.277	.346	.527	.873	1229	324.4	.369	132	297.5
7	Adrian Beltre A. Beltre	435	2,566	9,825	1,351	2,828	570	31	1,533	717	86	1,510	88	29	10,727	4,765	1,036	5	94	98	258	.288	.339	.485	.824	1522	254.9	.352	117	209.4
8	Edwin Encarnacion E. Encarnacion	424	1,960	7,040	1,099	1,832	370	10	1,261	903	105	1,426	61	14	8,114	3,494	804	0	66	54	185	.260	.350	.496	.846	1233	280.2	.362	125	235.4
9	Mark Teixeira M. Teixeira	409	1,862	6,936	1,099	1,862	408	18	1,298	918	111	1,441	26	7	8,029	3,533	835	0	64	91	158	.268	.360	.509	.869	1268	317.6	.371	127	262.4
10	Alfonso Soriano A. Soriano	409	1,944	7,692	1,145	2,085	478	31	1,155	495	86	1,785	287	83	8,334	3,852	918	7	54	68	123	.271	.320	.501	.821	1161	167.3	.349	111	118.3
11	Carlos Beltran C. Beltran	406	2,318	8,675	1,409	2,423	518	64	1,428	1,000	46	1,591	269	41	9,832	4,287	988	16	95	100	172	.279	.353	.494	.848	1479	311.9	.362	123	272.4
12	Paul Konerko P. Konerko	387	1,983	7,132	986	1,985	344	3	1,205	812	89	1,209	7	3	8,108	3,496	734	0	75	80	230	.278	.356	.490	.846	1223	257.6	.363	120	203.2
13	Ryan Howard R. Howard	382	1,572	5,707	848	1,475	277	21	1,194	709	59	1,843	12	5	6,530	2,940	680	0	55	154	116	.258	.343	.515	.859	976	212.1	.361	121	175.3
14	Jim Thome J. Thome	379	1,469	4,788	868	1,295	237	9	1,014	983	36	1,495	2	9	5,847	2,687	625	0	40	119	93	.270	.396	.561	.957	1077	368.3	.403	146	337.1
15	Aramis Ramirez A. Ramirez	374	2,031	7,575	1,054	2,169	469	20	1,351	599	118	1,121	29	17	8,373	3,800	863	0	81	58	221	.286	.345	.502	.846	1256	263.9	.362	119	197.9
16	Ryan Braun R. Braun	352	1,766	6,622	1,080	1,963	408	49	1,154	586	77	1,363	216	60	7,329	3,525	809	0	44	56	179	.296	.358	.532	.891	1210	352.7	.379	135	310.8
17	Giancarlo Stanton G. Stanton	347	1,324	4,839	762	1,299	265	11	893	647	49	1,559	42	15	5,568	2,627	623	0	33	81	117	.268	.358	.543	.901	932	289	.380	142	279.1
18	Jose Bautista J. Bautista	344	1,798	6,051	1,022	1,496	312	17	975	1,032	80	1,394	70	32	7,244	2,874	673	23	58	58	170	.247	.361	.475	.836	1085	241.2	.362	126	211.3
19	Curtis Granderson C. Granderson	344	2,057	7,236	1,217	1,800	346	95	937	924	67	1,916	153	50	8,306	3,368	785	30	49	31	64	.249	.337	.465	.803	1149	173.1	.347	115	147.8
20	Lance Berkman L. Berkman	341	1,731	6,045	1,060	1,778	392	29	1,152	1,133	65	1,206	75	45	7,290	3,251	762	1	46	159	139	.294	.408	.538	.946	1335	457.5	.402	145	416.3
21	Torii Hunter T. Hunter	339	2,131	8,120	1,200	2,256	466	30	1,310	615	89	1,595	181	89	8,893	3,799	835	5	64	49	239	.278	.333	.468	.801	1209	159.2	.345	113	139.6
22	Robinson Cano R. Cano	334	2,234	8,673	1,257	2,624	571	33	1,302	616	85	1,189	51	38	9,446	4,263	938	10	62	112	284	.303	.352	.492	.844	1411	303.4	.360	125	284.7
23	Joey Votto J. Votto	331	1,900	6,722	1,114	2,027	435	21	1,065	1,294	64	1,481	80	29	8,128	3,497	787	0	48	147	158	.302	.416	.520	.937	1489	538.2	.400	149	476.6
24	Justin Upton J. Upton	324	1,828	6,673	1,056	1,748	349	38	1,000	779	75	1,948	151	59	7,589	3,145	711	3	59	49	141	.262	.343	.471	.814	1079	197.7	.350	118	159.1
25	Jay Bruce J. Bruce	319	1,650	5,964	839	1,455	312	32	951	600	28	1,572	65	40	6,641	2,788	663	3	46	71	101	.244	.314	.467	.781	847	79.1	.332	106	47.7