Between the 2001 and 2022 seasons, Albert Pujols crushed the most home runs, with 703 homers.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	wRC	WRAA	wOBA	wRC+	BRAA
1	Albert Pujols A. Pujols	703	3,080	11,421	1,914	3,384	686	16	2,218	1,373	123	1,404	117	43	13,041	6,211	1,405	1	123	316	426	.296	.374	.544	.918	2233	685	.385	141	673
2	David Ortiz D. Ortiz	521	2,167	7,878	1,302	2,262	573	18	1,653	1,216	33	1,566	15	9	9,211	4,434	1,112	2	82	204	212	.287	.381	.563	.944	1638	550.4	.396	143	481.6
3	Miguel Cabrera M. Cabrera	507	2,699	10,022	1,530	3,088	607	17	1,847	1,227	72	2,031	40	21	11,426	5,250	1,131	5	100	238	353	.308	.384	.524	.908	1942	591.2	.384	140	552.6
4	Alex Rodriguez A. Rodriguez	507	1,994	7,440	1,394	2,149	354	18	1,491	1,028	145	1,671	196	40	8,692	4,060	879	0	79	88	198	.289	.382	.546	.928	1543	501.9	.394	142	455
5	Adam Dunn A. Dunn	462	2,001	6,883	1,097	1,631	334	10	1,168	1,317	86	2,379	63	25	8,328	3,371	806	2	40	122	100	.237	.364	.490	.854	1285	297.9	.367	123	240
6	Nelson Cruz N. Cruz	459	2,006	7,358	1,081	2,018	367	14	1,302	732	84	1,870	83	32	8,235	3,790	840	2	59	77	177	.274	.344	.515	.859	1279	317.1	.365	129	289.3
7	Adrian Beltre A. Beltre	435	2,566	9,825	1,351	2,828	570	31	1,533	717	86	1,510	88	29	10,727	4,765	1,036	5	94	98	258	.288	.339	.485	.824	1522	254.9	.352	117	209.4
8	Edwin Encarnacion E. Encarnacion	424	1,960	7,040	1,099	1,832	370	10	1,261	903	105	1,426	61	14	8,114	3,494	804	0	66	54	185	.260	.350	.496	.846	1233	280.2	.362	125	235.4
9	Mark Teixeira M. Teixeira	409	1,862	6,936	1,099	1,862	408	18	1,298	918	111	1,441	26	7	8,029	3,533	835	0	64	91	158	.268	.360	.509	.869	1268	317.6	.371	127	262.4
10	Alfonso Soriano A. Soriano	409	1,944	7,692	1,145	2,085	478	31	1,155	495	86	1,785	287	83	8,334	3,852	918	7	54	68	123	.271	.320	.501	.821	1161	167.3	.349	111	118.3
11	Carlos Beltran C. Beltran	406	2,318	8,675	1,409	2,423	518	64	1,428	1,000	46	1,591	269	41	9,832	4,287	988	16	95	100	172	.279	.353	.494	.848	1479	311.9	.362	123	272.4
12	Paul Konerko P. Konerko	387	1,983	7,132	986	1,985	344	3	1,205	812	89	1,209	7	3	8,108	3,496	734	0	75	80	230	.278	.356	.490	.846	1223	257.6	.363	120	203.2
13	Ryan Howard R. Howard	382	1,572	5,707	848	1,475	277	21	1,194	709	59	1,843	12	5	6,530	2,940	680	0	55	154	116	.258	.343	.515	.859	976	212.1	.361	121	175.3
14	Jim Thome J. Thome	379	1,469	4,788	868	1,295	237	9	1,014	983	36	1,495	2	9	5,847	2,687	625	0	40	119	93	.270	.396	.561	.957	1077	368.3	.403	146	337.1
15	Giancarlo Stanton G. Stanton	378	1,434	5,237	815	1,383	272	11	971	697	49	1,696	42	15	6,019	2,811	661	0	36	83	125	.264	.354	.537	.890	989	295.1	.376	140	287.1
16	Aramis Ramirez A. Ramirez	374	2,031	7,575	1,054	2,169	469	20	1,351	599	118	1,121	29	17	8,373	3,800	863	0	81	58	221	.286	.345	.502	.846	1256	263.9	.362	119	197.9
17	Ryan Braun R. Braun	352	1,766	6,622	1,080	1,963	408	49	1,154	586	77	1,363	216	60	7,329	3,525	809	0	44	56	179	.296	.358	.532	.891	1210	352.7	.379	135	310.8
18	Mike Trout M. Trout	350	1,407	5,094	1,052	1,543	296	51	896	919	92	1,354	204	37	6,158	2,991	697	0	53	117	64	.303	.415	.587	1.002	1234	521.2	.419	172	523.8
19	Jose Bautista J. Bautista	344	1,798	6,051	1,022	1,496	312	17	975	1,032	80	1,394	70	32	7,244	2,874	673	23	58	58	170	.247	.361	.475	.836	1085	241.2	.362	126	211.3
20	Curtis Granderson C. Granderson	344	2,057	7,236	1,217	1,800	346	95	937	924	67	1,916	153	50	8,306	3,368	785	30	49	31	64	.249	.337	.465	.803	1149	173.1	.347	115	147.8
21	Joey Votto J. Votto	342	1,991	7,044	1,145	2,093	453	22	1,106	1,338	74	1,578	80	29	8,504	3,616	817	0	48	147	166	.297	.412	.513	.926	1532	538.1	.396	146	473.7
22	Lance Berkman L. Berkman	341	1,731	6,045	1,060	1,778	392	29	1,152	1,133	65	1,206	75	45	7,290	3,251	762	1	46	159	139	.294	.408	.538	.946	1335	457.5	.402	145	416.3
23	Torii Hunter T. Hunter	339	2,131	8,120	1,200	2,256	466	30	1,310	615	89	1,595	181	89	8,893	3,799	835	5	64	49	239	.278	.333	.468	.801	1209	159.2	.345	113	139.6
24	Robinson Cano R. Cano	335	2,267	8,773	1,262	2,639	572	33	1,306	620	85	1,214	51	38	9,550	4,282	940	10	62	112	286	.301	.351	.488	.839	1411	291.8	.358	124	273.3
25	Evan Longoria E. Longoria	331	1,912	7,095	992	1,883	422	26	1,131	707	72	1,623	58	19	7,969	3,350	779	1	94	87	198	.265	.334	.472	.806	1092	165.4	.344	118	173.1