Rickey Henderson has made the most career plate appearances when leading off a game, with 2,875 plate appearances.

	NAME	PA	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	TB	XBH	SH	SF	IBB	AVG	OBP	SLG	OPS
1	Rickey Henderson R. Henderson	2,875	2,875	2,462	680	117	17	81	81	394	19	408	1,074	215	0	0	0	.276	.380	.436	.816
2	Brett Butler B. Butler	1,844	1,844	1,637	473	55	22	8	8	202	5	174	596	85	0	0	0	.289	.369	.364	.733
3	Ichiro Suzuki I. Suzuki	1,822	1,822	1,750	544	80	16	37	37	65	7	182	767	133	0	0	0	.311	.338	.438	.776
4	Kenny Lofton K. Lofton	1,705	1,705	1,487	448	68	22	29	29	211	7	227	647	119	0	0	0	.301	.391	.435	.826
5	Johnny Damon J. Damon	1,575	1,575	1,422	388	62	13	27	27	147	6	201	557	102	0	0	0	.273	.343	.392	.735
6	Paul Molitor P. Molitor	1,570	1,570	1,451	423	78	19	33	33	111	8	188	638	130	0	0	0	.292	.345	.440	.785
7	Craig Biggio C. Biggio	1,560	1,560	1,407	400	106	9	53	53	114	39	233	683	168	0	0	0	.284	.354	.485	.840
8	Jimmy Rollins J. Rollins	1,507	1,507	1,438	386	91	10	46	46	65	4	179	635	147	0	0	0	.268	.302	.442	.744
9	Jose Reyes J. Reyes	1,445	1,445	1,359	393	75	16	26	26	86	0	181	578	117	0	0	0	.289	.331	.425	.757
10	Juan Pierre J. Pierre	1,439	1,439	1,349	420	46	15	4	4	74	16	88	508	65	0	0	0	.311	.354	.377	.731
11	Tim Raines T. Raines	1,398	1,398	1,252	361	60	26	16	16	137	9	146	521	102	0	0	0	.288	.363	.416	.779
12	Rafael Furcal R. Furcal	1,389	1,389	1,301	363	54	13	30	30	85	2	181	533	97	0	0	0	.279	.324	.410	.734
13	Tony Phillips T. Phillips	1,381	1,381	1,187	317	56	7	30	30	190	4	249	477	93	0	0	0	.267	.370	.402	.772
14	Willie Wilson W. Wilson	1,376	1,376	1,298	352	31	21	11	11	67	11	208	458	63	0	0	0	.271	.313	.353	.665
15	Brady Anderson B. Anderson	1,294	1,294	1,139	298	63	10	44	44	132	23	196	513	117	0	0	0	.262	.350	.450	.800
16	Chuck Knoblauch C. Knoblauch	1,289	1,289	1,127	309	51	9	31	31	139	23	152	471	91	0	0	0	.274	.365	.418	.783
17	Vince Coleman V. Coleman	1,275	1,275	1,149	303	42	20	5	5	118	8	232	400	67	0	0	0	.264	.336	.348	.685
18	Eric Young E. Young	1,242	1,242	1,097	296	59	14	20	20	128	17	112	443	93	0	0	0	.270	.355	.404	.759
19	Shannon Stewart S. Stewart	1,169	1,169	1,075	309	61	7	23	23	81	13	134	453	91	0	0	0	.287	.345	.421	.766
20	Denard Span D. Span	1,157	1,157	1,042	257	57	8	15	15	112	3	157	375	80	0	0	0	.247	.322	.360	.681
21	Brian Roberts B. Roberts	1,133	1,133	1,037	277	74	3	13	13	96	0	138	396	90	0	0	0	.267	.329	.382	.711
22	Ian Kinsler I. Kinsler	1,129	1,129	1,034	240	50	7	48	48	79	16	158	448	105	0	0	0	.232	.297	.433	.730
23	Steve Sax S. Sax	1,101	1,101	1,027	268	35	6	12	12	71	3	89	351	53	0	0	0	.261	.311	.342	.652
24	Pete Rose P. Rose	1,097	1,097	1,001	285	56	3	5	5	87	9	60	362	64	0	0	0	.285	.347	.362	.709
25	Lenny Dykstra L. Dykstra	1,095	1,095	951	236	54	13	20	20	136	8	132	376	87	0	0	0	.248	.347	.395	.742