The Tampa Bay Rays had their highest run differential in a game on April 14, on April 19, 2014 and on September 5, 2007, with a differential of 15 runs.

Interpreted as:

rays largest margin of victory in a regular-season game

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rays	15	4/14/2025	TBR	vs	BOS	W 16-1	40	16	16	2	0	4	16	4	0	9	1	0	44	30	6	0	0	0	1	.400	.455	.750	1.205
2	Rays	15	4/19/2014	TBR	vs	NYY	W 16-1	40	16	16	4	0	5	15	5	0	7	0	0	46	35	9	0	1	1	0	.400	.457	.875	1.332
3	Devil Rays	15	9/5/2007	TBD	vs	BAL	W 17-2	46	17	22	4	0	5	17	5	0	7	1	0	52	41	9	0	1	0	0	.478	.519	.891	1.411
4	Rays	14	8/19/2023	TBR	@	LAA	W 18-4	46	18	19	4	0	3	18	7	1	9	0	0	55	32	7	0	1	1	1	.413	.491	.696	1.187
5	Rays	14	7/29/2021	TBR	vs	NYY	W 14-0	36	14	12	2	0	4	13	4	0	14	0	0	41	26	6	0	1	0	0	.333	.390	.722	1.112
6	Rays	14	8/16/2016	TBR	vs	SDP	W 15-1	40	15	16	4	1	5	15	3	1	5	0	0	44	37	10	0	0	0	0	.400	.455	.925	1.380
7	Rays	13	5/31/2025	TBR	@	HOU	W 16-3	44	16	18	7	0	5	16	4	0	12	1	0	48	40	12	0	0	1	0	.409	.458	.909	1.367
8	Rays	13	5/25/2025	TBR	vs	TOR	W 13-0	39	13	15	3	0	2	13	4	1	4	3	0	44	24	5	0	0	0	1	.385	.455	.615	1.070
9	Rays	13	7/25/2024	TBR	@	TOR	W 13-0	42	13	16	5	0	1	13	6	2	8	2	0	51	24	6	0	1	0	0	.381	.471	.571	1.042
10	Rays	13	7/14/2018	TBR	@	MIN	W 19-6	44	19	20	5	1	3	19	4	1	7	0	1	50	36	9	0	1	1	0	.455	.500	.818	1.318
11	Rays	13	5/22/2009	TBR	@	FLA	W 15-2	44	15	17	3	0	3	15	9	1	9	1	0	54	29	6	0	0	0	1	.386	.500	.659	1.159
12	Rays	13	4/30/2009	TBR	vs	BOS	W 13-0	42	13	18	7	0	2	13	5	0	11	1	0	47	31	9	0	0	0	0	.429	.489	.738	1.227
13	Devil Rays	13	7/29/2006	TBD	@	NYY	W 19-6	43	19	17	6	0	4	18	5	2	5	1	0	52	35	10	1	1	0	0	.395	.471	.814	1.285
14	Devil Rays	13	9/19/1999	TBD	@	TEX	W 15-2	42	15	15	4	0	3	15	3	2	10	0	1	47	28	7	0	0	0	0	.357	.426	.667	1.092
15	Rays	12	7/12/2019	TBR	@	BAL	W 16-4	48	16	20	7	0	2	12	1	0	4	1	0	49	33	9	0	0	0	1	.417	.429	.688	1.116
16	Rays	12	9/7/2018	TBR	vs	BAL	W 14-2	32	14	10	1	0	4	13	11	0	6	1	1	44	23	5	0	1	0	0	.313	.477	.719	1.196
17	Rays	12	8/28/2017	TBR	@	KCR	W 12-0	35	12	12	4	2	3	12	5	0	3	0	0	41	29	9	0	1	0	2	.343	.415	.829	1.243
18	Rays	12	8/3/2016	TBR	vs	KCR	W 12-0	38	12	14	1	1	3	12	7	1	5	2	1	47	26	5	0	1	0	1	.368	.468	.684	1.152
19	Rays	12	7/1/2013	TBR	@	HOU	W 12-0	43	12	17	3	0	2	12	7	0	10	0	0	51	26	5	0	1	0	0	.395	.471	.605	1.075
20	Rays	12	8/28/2011	TBR	@	TOR	W 12-0	41	12	14	3	1	3	11	9	2	7	2	0	53	28	7	0	1	0	0	.341	.472	.683	1.155
21	Rays	12	4/28/2011	TBR	@	MIN	W 15-3	45	15	19	3	1	2	14	6	0	6	3	0	52	30	6	0	1	0	1	.422	.481	.667	1.147
22	Rays	12	9/11/2010	TBR	@	TOR	W 13-1	37	13	10	4	2	2	13	7	2	13	0	0	46	24	8	0	0	0	0	.270	.413	.649	1.062
23	Rays	12	4/21/2010	TBR	@	CWS	W 12-0	36	12	13	4	0	1	12	8	0	10	0	1	47	20	5	1	2	0	0	.361	.457	.556	1.012
24	Rays	12	6/25/2008	TBR	@	FLA	W 15-3	43	15	15	4	0	4	14	9	1	10	0	0	53	31	8	0	0	0	0	.349	.472	.721	1.193
25	Rays	11	6/30/2023	TBR	@	SEA	W 15-4	43	15	16	5	1	3	15	4	0	8	3	0	48	32	9	0	1	0	1	.372	.417	.744	1.161