Between the 2000 and 2006 seasons, Randy Johnson struck out the most hitters, with 1,851 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Randy Johnson R. Johnson	1,851	225	120	59	.670	224	3.16	30	12	0	1548.2	1,283	543	617	162	396	77	1	11	6,263	26	10.76	2.30	4.67	0.94	29.6	6.3	1.08	.297	3.59	70	2.93	66	7.46	262.2
2	Pedro Martinez P. Martinez	1,464	193	99	42	.702	193	2.78	18	6	0	1286.1	963	397	431	106	291	74	0	6	5,105	21	10.24	2.04	5.03	0.74	28.7	5.7	0.97	.270	3.02	61	2.69	62	6.74	244.7
3	Curt Schilling C. Schilling	1,444	219	108	55	.663	197	3.51	25	6	9	1418.1	1,350	553	562	173	234	19	21	8	5,735	23	9.16	1.48	6.17	1.10	25.2	4.1	1.12	.305	3.57	77	3.13	71	8.57	203.2
4	Javier Vazquez J. Vazquez	1,350	231	86	82	.512	230	4.08	17	6	0	1518.2	1,509	689	742	195	373	47	0	34	6,377	46	8.00	2.21	3.62	1.16	21.2	5.8	1.24	.298	4.40	91	3.77	84	8.94	120.8
5	Roger Clemens R. Clemens	1,288	211	101	44	.697	211	3.27	3	1	0	1355.1	1,169	493	544	120	447	40	0	19	5,609	46	8.55	2.97	2.88	0.80	23.0	8.0	1.19	.282	3.61	73	3.37	75	7.76	165.7
6	Mike Mussina M. Mussina	1,247	221	103	68	.602	221	3.80	18	9	0	1438.1	1,399	607	653	163	298	29	0	9	5,904	30	7.80	1.86	4.18	1.02	21.1	5.0	1.18	.297	4.09	85	3.47	77	8.75	163.1
7	Jason Schmidt J. Schmidt	1,193	187	86	48	.642	187	3.55	15	9	0	1217.0	1,023	480	520	103	463	29	0	20	5,082	53	8.82	3.42	2.58	0.76	23.5	9.1	1.22	.279	3.85	83	3.39	80	7.57	115.4
8	Johan Santana J. Santana	1,146	218	78	31	.716	142	3.20	5	3	1	1089.2	885	387	412	111	312	23	23	2	4,403	48	9.47	2.58	3.67	0.92	26.0	7.1	1.10	.275	3.40	70	3.19	73	7.31	142.5
9	Barry Zito B. Zito	1,096	222	102	63	.618	222	3.55	9	4	0	1430.1	1,228	564	620	148	560	65	0	14	5,998	26	6.90	3.52	1.96	0.93	18.3	9.3	1.25	.262	3.90	80	4.16	93	7.73	47.3
10	Bartolo Colon B. Colon	1,081	208	104	66	.612	208	3.91	23	5	0	1373.0	1,326	596	638	172	450	22	0	15	5,758	24	7.09	2.95	2.40	1.13	18.8	7.8	1.29	.286	4.18	86	4.12	92	8.69	56.3
11	Livan Hernandez L. Hernandez	1,076	237	96	90	.516	237	4.12	31	7	0	1633.1	1,726	747	808	172	531	48	0	47	7,003	22	5.93	2.93	2.03	0.95	15.4	7.6	1.38	.300	4.45	97	4.16	97	9.51	24.5
12	Matt Clement M. Clement	1,069	203	75	74	.503	203	4.47	6	3	0	1218.1	1,121	605	648	126	557	85	0	20	5,324	88	7.90	4.11	1.92	0.93	20.1	10.5	1.38	.285	4.79	104	4.21	97	8.28	17.8
13	Kerry Wood K. Wood	1,066	163	58	50	.537	152	3.72	10	4	0	962.0	758	398	423	114	461	70	4	10	4,079	40	9.97	4.31	2.31	1.07	26.1	11.3	1.27	.272	3.96	87	4.01	91	7.09	42.2
14	Freddy Garcia F. Garcia	1,032	219	99	63	.611	218	4.00	10	3	0	1442.1	1,379	641	679	173	439	41	0	23	6,064	57	6.44	2.74	2.35	1.08	17.0	7.2	1.26	.275	4.24	90	4.17	93	8.60	51.5
15	Kevin Millwood K. Millwood	1,027	216	83	69	.546	214	4.02	9	4	0	1320.2	1,295	590	634	138	391	31	0	30	5,577	27	7.00	2.66	2.63	0.94	18.4	7.0	1.28	.290	4.32	92	3.81	87	8.83	85.5
16	Tim Hudson T. Hudson	1,023	226	108	58	.651	226	3.56	19	9	0	1514.2	1,442	599	661	131	464	61	0	46	6,346	44	6.08	2.76	2.20	0.78	16.1	7.3	1.26	.281	3.93	80	3.86	87	8.57	101.6
17	Roy Oswalt R. Oswalt	1,016	188	98	47	.676	177	3.05	11	4	0	1201.1	1,153	407	443	98	263	41	5	18	4,926	15	7.61	1.97	3.86	0.73	20.6	5.3	1.18	.301	3.32	70	3.16	72	8.64	162.5
18	Greg Maddux G. Maddux	1,009	241	112	77	.593	241	3.58	15	7	0	1547.2	1,540	615	680	161	253	45	0	51	6,330	17	5.87	1.47	3.99	0.94	15.9	4.0	1.16	.284	3.95	82	3.68	83	8.96	128.1
19	Andy Pettitte A. Pettitte	994	202	105	58	.644	201	3.73	11	3	0	1268.0	1,311	525	598	110	345	20	1	23	5,377	19	7.06	2.45	2.88	0.78	18.5	6.4	1.31	.307	4.24	83	3.48	77	9.31	142.4
20	Ben Sheets B. Sheets	942	166	61	69	.469	166	3.83	11	1	0	1088.1	1,083	463	514	126	229	29	0	21	4,518	37	7.79	1.89	4.11	1.04	20.8	5.1	1.21	.300	4.25	90	3.51	80	8.96	104
21	CC Sabathia	933	185	81	56	.591	185	3.95	12	4	0	1165.1	1,080	512	552	111	427	35	0	13	4,898	28	7.21	3.30	2.19	0.86	19.0	8.7	1.29	.286	4.26	89	3.86	89	8.34	64.7
22	Jeff Weaver J. Weaver	930	227	77	89	.464	211	4.47	13	5	2	1404.1	1,496	697	750	165	372	93	6	23	6,044	30	5.96	2.38	2.50	1.06	15.4	6.2	1.33	.297	4.81	102	4.24	96	9.59	23.4
23	Esteban Loaiza E. Loaiza	928	220	84	69	.549	207	4.54	10	5	1	1321.2	1,478	667	711	158	357	49	4	18	5,709	18	6.32	2.43	2.60	1.08	16.3	6.3	1.39	.313	4.84	99	4.12	90	10.06	62.3
24	Tim Wakefield T. Wakefield	910	264	72	67	.518	168	4.26	4	0	7	1247.1	1,182	591	668	165	442	80	30	17	5,351	45	6.57	3.19	2.06	1.19	17.0	8.3	1.30	.271	4.82	91	4.56	104	8.53	-30.4
25	Kelvim Escobar K. Escobar	908	298	59	67	.468	131	4.11	6	3	45	1021.2	972	466	507	101	406	33	105	22	4,372	39	8.00	3.58	2.24	0.89	20.8	9.3	1.35	.298	4.47	88	3.86	85	8.56	75.4