Between the 2000 and 2009 seasons, Randy Johnson struck out the most batters, with 2,182 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Randy Johnson R. Johnson	2,182	287	143	78	.647	281	3.34	32	12	0	1885.1	1,616	699	790	212	484	89	3	22	7,686	34	10.42	2.31	4.51	1.01	28.4	6.3	1.11	.298	3.77	75	3.12	70	7.71	275.2
2	Javier Vazquez J. Vazquez	2,001	328	128	116	.525	327	3.98	23	6	0	2163.0	2,101	957	1,025	269	528	64	0	40	9,023	59	8.33	2.20	3.79	1.12	22.2	5.9	1.22	.297	4.26	89	3.66	82	8.74	195
3	Johan Santana J. Santana	1,733	310	122	60	.670	234	3.12	9	6	1	1709.2	1,430	592	641	187	473	34	23	10	6,946	65	9.12	2.49	3.66	0.98	24.9	6.8	1.11	.275	3.37	70	3.37	78	7.53	181.5
4	Pedro Martinez P. Martinez	1,620	227	112	50	.691	227	3.01	18	6	0	1468.0	1,171	491	530	132	350	86	0	10	5,917	24	9.93	2.15	4.63	0.81	27.4	5.9	1.04	.279	3.25	68	2.91	67	7.18	241.6
5	CC Sabathia	1,590	288	136	81	.627	288	3.62	28	11	0	1889.1	1,738	760	827	168	590	59	0	22	7,834	36	7.57	2.81	2.69	0.80	20.3	7.5	1.23	.289	3.94	82	3.58	82	8.28	166.2
6	Curt Schilling C. Schilling	1,545	243	117	63	.650	221	3.54	26	7	9	1569.1	1,515	618	630	194	257	21	21	9	6,368	23	8.86	1.47	6.01	1.11	24.3	4.0	1.13	.304	3.61	78	3.23	73	8.69	204.8
7	Barry Zito B. Zito	1,501	321	133	106	.556	320	3.84	10	4	0	1999.0	1,775	852	929	209	826	81	0	36	8,484	36	6.76	3.72	1.82	0.94	17.7	9.7	1.30	.267	4.18	88	4.29	98	7.99	23.4
8	Mike Mussina M. Mussina	1,488	283	134	87	.606	282	3.87	18	9	0	1790.2	1,801	769	828	194	364	41	0	14	7,379	35	7.48	1.83	4.09	0.98	20.2	4.9	1.21	.304	4.16	86	3.50	78	9.05	192.8
9	Roy Oswalt R. Oswalt	1,473	283	137	70	.662	271	3.23	18	6	0	1803.1	1,756	647	695	154	412	66	5	30	7,455	21	7.35	2.06	3.58	0.77	19.8	5.5	1.20	.299	3.47	75	3.34	76	8.76	208.1
10	Andy Pettitte A. Pettitte	1,441	303	148	89	.624	300	3.90	11	3	0	1882.0	1,975	815	917	165	545	32	1	29	8,008	31	6.89	2.61	2.64	0.79	18.0	6.8	1.34	.311	4.39	87	3.61	81	9.44	179.8
11	A.J. Burnett	1,440	241	96	83	.536	237	3.85	20	9	0	1542.0	1,355	660	721	144	640	70	1	21	6,531	83	8.40	3.74	2.25	0.84	22.0	9.8	1.29	.286	4.21	90	3.80	87	7.91	92.9
12	Roy Halladay R. Halladay	1,400	275	139	69	.668	267	3.40	47	14	0	1883.1	1,832	712	790	151	374	52	4	21	7,712	37	6.69	1.79	3.74	0.72	18.2	4.8	1.17	.293	3.78	74	3.31	74	8.75	243.9
13	Kevin Millwood K. Millwood	1,398	307	115	103	.528	305	4.18	15	4	0	1860.2	1,923	865	937	201	578	56	0	35	7,982	41	6.76	2.80	2.42	0.97	17.5	7.2	1.34	.300	4.53	94	4.00	90	9.30	87.6
14	Jake Peavy J. Peavy	1,366	215	95	68	.583	215	3.26	7	3	0	1362.2	1,169	494	525	136	441	45	0	31	5,626	26	9.02	2.91	3.10	0.90	24.3	7.8	1.18	.284	3.47	82	3.45	82	7.72	115.8
15	Roger Clemens R. Clemens	1,356	229	107	50	.682	228	3.34	3	1	0	1454.1	1,268	539	596	129	478	45	0	19	6,029	53	8.39	2.96	2.84	0.80	22.5	7.9	1.20	.283	3.69	75	3.42	76	7.85	169.1
16	Livan Hernandez L. Hernandez	1,335	332	129	124	.510	332	4.46	36	7	0	2201.1	2,450	1,091	1,165	250	720	57	0	57	9,533	29	5.46	2.94	1.85	1.02	14.0	7.6	1.44	.307	4.76	104	4.40	102	10.02	-19.5
17	Josh Beckett J. Beckett	1,330	228	106	68	.609	225	3.79	9	4	0	1401.0	1,280	590	641	151	426	48	1	14	5,835	44	8.54	2.74	3.12	0.97	22.8	7.3	1.22	.291	4.12	86	3.60	84	8.22	103.1
18	Carlos Zambrano C. Zambrano	1,324	259	105	68	.607	238	3.51	9	4	0	1551.1	1,313	605	669	126	698	81	4	36	6,593	49	7.68	4.05	1.90	0.73	20.1	10.6	1.30	.272	3.88	80	3.94	89	7.62	82.3
19	Ted Lilly T. Lilly	1,280	271	103	83	.554	252	4.20	4	2	0	1501.0	1,397	700	744	219	528	43	4	22	6,384	50	7.67	3.17	2.42	1.31	20.1	8.3	1.28	.273	4.46	93	4.42	99	8.38	8.4
20	Randy Wolf R. Wolf	1,271	257	95	76	.556	254	4.02	12	8	0	1560.2	1,482	697	745	192	538	68	1	30	6,613	28	7.33	3.10	2.36	1.11	19.2	8.1	1.29	.284	4.30	95	4.20	97	8.55	21.9
21	Tim Hudson T. Hudson	1,270	290	137	76	.643	289	3.50	21	11	0	1923.1	1,837	749	818	156	570	71	0	59	8,024	52	5.94	2.67	2.23	0.73	15.8	7.1	1.25	.282	3.83	79	3.81	86	8.60	135.6
22	Kerry Wood K. Wood	1,237	308	67	58	.536	152	3.71	10	4	54	1107.2	878	457	482	124	520	80	112	15	4,697	47	10.05	4.23	2.38	1.01	26.3	11.1	1.26	.276	3.92	86	3.89	88	7.13	63.2
23	Jason Schmidt J. Schmidt	1,223	197	89	54	.622	197	3.63	15	9	0	1260.1	1,071	509	552	108	489	33	0	23	5,290	55	8.73	3.49	2.50	0.77	23.1	9.2	1.24	.280	3.94	85	3.46	82	7.65	110.3
24	Bartolo Colon B. Colon	1,222	246	117	82	.588	245	4.07	23	5	0	1573.2	1,571	712	777	205	510	31	0	19	6,660	26	6.99	2.92	2.40	1.17	18.3	7.7	1.32	.291	4.44	90	4.22	94	8.98	45
25	Greg Maddux G. Maddux	1,211	308	134	101	.570	308	3.70	16	7	0	1939.2	1,965	797	877	196	308	57	0	59	7,964	24	5.62	1.43	3.93	0.91	15.2	3.9	1.17	.286	4.07	86	3.70	85	9.12	147.3