The Kansas City Athletics scored the most runs by a team in a game in 1961, with 20 runs against the Twins on April 25, 1961.

Interpreted as:

team most runs in a regular-season game 1961

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Athletics	20	4/25/1961	KCA	vs	MIN	W 20-2	39	16	5	3	0	17	10	0	5	0	0	50	27	8	0	1	1	0	.410	.520	.692	1.212
2	Phillies	19	9/12/1961	PHI	@	LAD	W 19-10	45	17	1	2	5	18	4	1	10	0	0	50	37	8	0	0	0	1	.378	.440	.822	1.262
3	Pirates	19	8/3/1961	PIT	@	STL	W 19-0	50	24	7	0	3	19	5	0	4	0	0	55	40	10	0	0	1	1	.480	.527	.800	1.327
4	Giants	19	7/4/1961	SFG	@	CHC	W 19-3	45	22	3	0	1	17	5	0	3	2	0	53	28	4	2	1	0	1	.489	.529	.622	1.152
5	Athletics	17	8/31/1961	KCA	@	LAA	W 17-3	45	19	1	1	4	15	5	0	8	1	0	50	34	6	0	0	0	2	.422	.480	.756	1.236
6	Tigers	17	8/12/1961	DET	@	MIN	W 17-3	43	17	4	0	1	16	10	0	5	0	0	54	24	5	1	0	1	0	.395	.509	.558	1.068
7	Tigers	17	7/23/1961	DET	@	KCA	W 17-14	45	17	4	1	0	15	8	0	5	2	0	54	23	5	0	1	0	0	.378	.463	.511	.974
8	Giants	16	7/25/1961	SFG	@	PIT	W 16-7	42	22	3	0	0	16	5	0	6	0	2	49	25	3	1	1	1	1	.524	.563	.595	1.158
9	Angels	16	7/21/1961	LAA	vs	WSH	W 16-5	43	20	2	1	1	15	8	2	8	2	0	55	27	4	1	1	0	1	.465	.556	.628	1.183
10	Cubs	16	6/28/1961	CHC	vs	CIN	W 16-5	41	17	4	1	3	14	5	2	5	0	0	48	32	8	0	0	0	1	.415	.500	.780	1.280
11	Tigers	15	7/20/1961	DET	vs	BAL	W 15-8	35	14	3	0	3	15	8	0	6	1	0	44	26	6	1	0	2	1	.400	.512	.743	1.254
12	Pirates	15	7/6/1961	PIT	@	CHC	W 15-3	47	20	4	1	1	14	6	0	7	0	0	53	29	6	0	0	1	1	.426	.491	.617	1.108
13	Cubs	15	6/29/1961	CHC	vs	CIN	W 15-8	38	17	4	0	4	15	7	1	6	0	0	48	33	8	0	2	3	0	.447	.521	.868	1.389
14	Tigers	15	6/23/1961	DET	@	CLE	W 15-7	41	15	2	1	4	15	7	1	7	0	1	49	31	7	0	0	0	0	.366	.469	.756	1.225
15	White Sox	15	6/21/1961	CWS	vs	CLE	W 15-3	39	14	1	0	3	15	3	1	2	1	0	43	24	4	0	0	0	0	.359	.419	.615	1.034
16	Red Sox	14	9/11/1961	BOS	@	WSH	W 14-4	40	13	3	0	1	13	11	0	3	0	0	51	19	4	0	0	0	1	.325	.471	.475	.946
17	Phillies	14	9/10/1961	PHI	@	CHC	W 14-6	40	12	0	0	2	12	7	2	3	1	0	50	18	2	1	0	1	2	.300	.429	.450	.879
18	Giants	14	8/23/1961	SFG	@	CIN	W 14-0	41	13	2	0	6	12	2	1	6	0	0	44	33	8	0	0	0	1	.317	.364	.805	1.169
19	Athletics	14	7/23/1961	KCA	vs	DET	L 14-17	46	17	5	0	2	13	7	1	9	1	0	54	28	7	0	0	0	0	.370	.463	.609	1.072
20	Reds	14	7/9/1961	CIN	@	LAD	W 14-3	42	15	3	0	3	14	7	1	6	0	0	51	27	6	0	1	3	1	.357	.451	.643	1.094
21	Yankees	14	7/7/1961	NYY	vs	BOS	W 14-3	40	16	3	0	1	14	3	0	5	0	0	44	22	4	0	1	0	1	.400	.432	.550	.982
22	Red Sox	14	6/16/1961	BOS	vs	WSH	W 14-9	32	11	2	1	0	14	15	1	2	0	0	50	15	3	2	0	0	1	.344	.563	.469	1.031
23	Indians	14	6/6/1961	CLE	@	WSH	W 14-3	39	16	1	1	3	13	4	0	0	0	0	46	28	5	2	1	0	2	.410	.455	.718	1.172
24	White Sox	14	5/28/1961	CWS	@	NYY	W 14-9	40	13	2	1	3	13	6	0	4	0	0	46	26	6	0	0	0	2	.325	.413	.650	1.063
25	Senators	14	5/27/1961	WSH	vs	MIN	W 14-4	40	19	6	2	3	14	3	2	7	0	0	46	38	11	0	1	0	0	.475	.522	.950	1.472