The St. Louis Cardinals had the highest OPS by a team against left-handed pitchers in 2022, with an OPS of .809.

	TEAM	OPS	SEASON	G	W%	W	L	AB	H	2B	3B	HR	RBI	BB	HBP	SO	PA	TB	XBH	SH	SF	IBB	AVG	OBP	SLG
1	Cardinals	.809	2022	111	.684	932	431	1,201	316	70	7	53	183	132	19	271	1,363	559	130	1	9	5	.263	.343	.465
2	Astros	.783	2022	128	.745	1,378	471	1,655	432	98	2	72	237	162	13	321	1,849	750	172	4	12	1	.261	.330	.453
3	Braves	.782	2022	106	.701	1,149	489	1,464	388	91	6	53	193	153	12	382	1,638	650	150	1	8	3	.265	.338	.444
4	Rockies	.770	2022	122	.480	943	1,021	1,793	491	107	17	53	255	136	18	397	1,964	791	177	2	15	5	.274	.329	.441
5	Phillies	.769	2022	129	.577	1,010	739	1,555	413	91	11	49	198	156	18	399	1,749	673	151	4	15	3	.266	.337	.433
6	Yankees	.768	2022	113	.682	1,056	493	1,351	328	58	3	67	205	162	17	350	1,549	593	128	7	9	11	.243	.329	.439
7	White Sox	.767	2022	104	.511	686	657	1,212	329	68	2	40	158	113	10	271	1,343	521	110	2	6	4	.271	.337	.430
8	Red Sox	.759	2022	129	.584	904	643	1,378	365	89	3	41	200	140	14	370	1,547	583	133	3	11	6	.265	.336	.423
9	Dodgers	.754	2022	130	.688	1,195	543	1,553	391	90	8	57	227	157	15	398	1,738	668	155	1	12	7	.252	.324	.430
10	Blue Jays	.753	2022	110	.499	618	621	1,112	284	60	2	42	153	109	11	246	1,239	474	104	1	6	7	.255	.326	.426
11	Rangers	.746	2022	125	.475	859	951	1,632	402	75	6	72	219	146	20	417	1,810	705	153	3	9	3	.246	.314	.432
12	Royals	.722	2022	129	.472	741	829	1,408	359	75	13	35	183	124	18	314	1,570	565	123	7	13	3	.255	.321	.401
13	Giants	.722	2022	137	.518	1,000	932	1,710	406	71	5	69	242	170	33	479	1,932	694	145	3	16	4	.237	.316	.406
14	Mets	.717	2022	131	.601	1,141	759	1,686	414	83	6	52	207	164	32	377	1,900	665	141	7	11	8	.246	.322	.394
15	Reds	.713	2022	117	.409	653	945	1,424	351	73	3	42	174	131	32	386	1,598	556	118	4	5	0	.246	.323	.390
16	Mariners	.711	2022	131	.573	1,018	760	1,540	359	71	7	50	196	190	28	410	1,778	594	128	3	16	7	.233	.325	.386
17	Rays	.710	2022	123	.570	814	614	1,298	332	74	4	31	162	114	10	296	1,428	507	109	1	5	4	.256	.320	.391
18	Padres	.705	2022	132	.582	1,086	781	1,659	407	73	8	48	199	166	21	381	1,867	640	129	7	14	6	.245	.319	.386
19	Cubs	.702	2022	119	.432	649	853	1,343	314	68	10	44	149	118	23	359	1,502	534	122	9	9	4	.234	.305	.398
20	Tigers	.701	2022	113	.473	725	807	1,405	371	77	6	28	170	101	8	340	1,532	544	111	3	15	5	.264	.314	.387
21	Twins	.701	2022	126	.524	902	819	1,539	370	78	6	47	174	145	17	375	1,721	601	131	5	15	3	.240	.310	.391
22	Nationals	.676	2022	127	.331	644	1,303	1,757	430	82	9	39	200	148	19	397	1,947	647	130	9	13	3	.245	.308	.368
23	Brewers	.674	2022	122	.524	896	813	1,504	334	63	4	48	156	162	31	440	1,709	549	115	4	8	4	.222	.309	.365
24	Orioles	.663	2022	123	.543	929	781	1,541	345	65	8	46	147	138	24	431	1,710	564	119	1	5	2	.224	.297	.366
25	Angels	.658	2022	125	.468	862	981	1,670	377	59	9	54	163	140	12	436	1,843	616	122	11	10	5	.226	.289	.369