The New York Yankees had the highest run differential by a team in 1942, with a differential of 294 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	GIDP	AVG	OBP	SLG	OPS
1	Yankees	294	1942	154	.669	103	51	5,305	801	1,429	223	57	108	744	591	29	556	69	33	6,009	2,090	388	84	103	.269	.346	.394	.740
2	Cardinals	275	1942	156	.688	106	48	5,422	755	1,454	282	69	60	680	551	22	505	71		6,125	2,054	411	130	90	.268	.338	.379	.717
3	Dodgers	230	1942	155	.675	104	50	5,286	742	1,398	263	34	62	678	572	14	485	81		5,991	1,915	359	119	95	.264	.338	.362	.700
4	Red Sox	167	1942	152	.612	93	59	5,248	761	1,451	244	55	103	702	591	22	508	68	61	5,984	2,114	402	123	94	.276	.352	.403	.755
5	Browns	93	1942	151	.543	82	69	5,229	730	1,354	239	62	98	669	609	13	608	37	38	5,947	2,011	399	96	115	.259	.338	.385	.722
6	Giants	74	1942	154	.559	85	67	5,210	675	1,323	162	35	109	632	557	34	507	39		5,881	1,882	306	80	140	.254	.330	.361	.691
7	Tigers	2	1942	156	.474	73	81	5,327	589	1,313	217	37	76	547	508	19	472	39	40	5,927	1,832	330	73	138	.246	.314	.344	.658
8	Reds	-18	1942	154	.500	76	76	5,260	527	1,216	198	39	66	488	485	23	549	42		5,860	1,690	303	92	96	.231	.299	.321	.620
9	Pirates	-47	1942	151	.449	66	81	5,107	585	1,250	173	49	54	544	535	26	539	41		5,754	1,683	276	86	105	.245	.320	.330	.649
10	Indians	-69	1942	156	.487	75	79	5,317	590	1,344	223	58	50	539	500	24	544	69	74	5,931	1,833	331	90	109	.253	.320	.345	.665
11	White Sox	-71	1942	148	.446	66	82	4,949	538	1,215	214	36	25	486	497	16	425	114	70	5,552	1,576	275	90	102	.246	.316	.318	.635
12	Cubs	-76	1942	155	.442	68	86	5,354	591	1,360	224	41	75	533	511	19	606	63		5,988	1,891	340	104	110	.254	.321	.353	.674
13	Braves	-130	1942	150	.399	59	89	5,077	515	1,216	210	19	68	479	474	20	509	49		5,660	1,668	297	89	114	.240	.307	.329	.635
14	Senators	-164	1942	151	.411	62	89	5,295	653	1,364	224	49	40	593	579	19	536	98	29	5,947	1,806	313	54	106	.258	.333	.341	.674
15	Athletics	-252	1942	154	.357	55	99	5,285	549	1,315	213	46	33	517	441	23	489	44	45	5,823	1,719	292	74	129	.249	.309	.325	.635
16	Phillies	-309	1942	151	.278	42	109	5,060	394	1,174	168	37	44	356	392	16	487	37		5,557	1,548	249	89	109	.232	.289	.306	.595