The St. Louis Cardinals had the highest run differential by a team in 1943, with a differential of 206 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	GIDP	AVG	OBP	SLG	OPS
1	Cardinals	206	1943	157	.682	105	49	5,435	679	1,515	259	72	70	638	428	19	437	40		6,055	2,128	401	173	92	.279	.334	.392	.725
2	Yankees	127	1943	155	.636	98	56	5,282	669	1,350	218	59	100	635	624	25	561	46	60	6,024	1,986	377	93	132	.256	.337	.376	.713
3	Tigers	72	1943	155	.506	78	76	5,364	632	1,401	200	47	77	572	483	13	552	40	43	5,983	1,926	324	123	159	.261	.324	.359	.683
4	Senators	71	1943	153	.549	84	69	5,233	666	1,328	245	50	47	619	605	39	574	142	55	5,965	1,814	342	88	94	.254	.336	.347	.682
5	Pirates	68	1943	157	.519	80	74	5,353	666	1,401	240	73	42	620	569	17	566	64		6,022	1,913	355	83	113	.262	.335	.357	.692
6	Reds	66	1943	155	.565	87	67	5,329	608	1,362	229	47	43	559	445	17	481	49		5,911	1,814	319	120	104	.256	.315	.340	.655
7	Dodgers	48	1943	153	.529	81	72	5,309	715	1,444	263	35	39	658	581	21	420	58		6,011	1,894	337	100	115	.272	.346	.357	.703
8	Cubs	33	1943	154	.484	74	79	5,279	631	1,380	207	56	52	580	575	21	530	53		5,972	1,855	315	97	117	.261	.336	.351	.688
9	Indians	23	1943	153	.536	82	71	5,269	600	1,344	246	45	55	564	567	11	519	47	58	5,967	1,845	346	120	110	.255	.329	.350	.679
10	Browns	-9	1943	153	.474	72	80	5,175	595	1,269	229	36	78	552	569	15	645	37	43	5,864	1,804	343	105	107	.245	.322	.349	.670
11	White Sox	-21	1943	155	.532	82	72	5,254	573	1,297	193	46	33	508	561	22	582	173	87	5,909	1,681	272	72	110	.247	.322	.320	.642
12	Red Sox	-44	1943	155	.447	68	84	5,392	563	1,314	223	42	57	511	486	19	591	86	61	6,010	1,792	322	113	103	.244	.308	.332	.641
13	Phillies	-107	1943	157	.416	64	90	5,297	569	1,321	186	36	66	528	495	21	553	29		5,912	1,777	288	99	140	.249	.316	.335	.651
14	Braves	-144	1943	153	.444	68	85	5,196	465	1,213	202	36	39	433	464	14	602	56		5,773	1,604	277	99	104	.233	.298	.309	.607
15	Giants	-151	1943	156	.359	55	98	5,290	559	1,309	153	33	81	518	479	24	466	35		5,896	1,771	267	103	147	.247	.313	.335	.648
16	Athletics	-220	1943	155	.318	49	105	5,244	497	1,219	174	44	26	462	430	29	465	55	42	5,798	1,559	244	95	132	.232	.294	.297	.592