The Boston Red Sox had the highest run differential by a team in 1946, with a differential of 198 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	GIDP	AVG	OBP	SLG	OPS
1	Red Sox	198	1946	156	.675	104	50	5,318	792	1,441	268	50	109	737	687	15	661	45	36	6,126	2,136	427	106	133	.271	.356	.402	.758
2	Cardinals	167	1946	156	.628	98	58	5,372	712	1,426	265	56	81	665	530	21	537	58		6,020	2,046	402	97	90	.265	.334	.381	.715
3	Tigers	137	1946	155	.597	92	62	5,318	704	1,373	212	41	108	644	624	13	616	65	41	6,059	1,991	361	104	125	.258	.338	.374	.712
4	Yankees	137	1946	154	.565	87	67	5,139	684	1,275	208	50	136	649	626	33	705	48	35	5,878	1,991	394	80	106	.248	.334	.387	.721
5	Dodgers	128	1946	157	.615	96	60	5,285	701	1,376	233	66	55	642	693	17	575	100		6,136	1,906	354	141	103	.260	.348	.361	.709
6	Cubs	46	1946	155	.536	82	71	5,298	626	1,344	223	50	56	566	586	24	599	43		6,024	1,835	329	116	130	.254	.331	.346	.677
7	Braves	37	1946	154	.529	81	72	5,225	630	1,377	238	48	44	596	558	22	466	60		5,940	1,843	330	135	111	.264	.337	.353	.690
8	White Sox	-33	1946	155	.481	74	80	5,312	562	1,364	206	44	37	515	499	20	602	78	64	5,909	1,769	287	78	134	.257	.323	.333	.656
9	Reds	-43	1946	156	.435	67	87	5,291	523	1,262	206	33	65	481	493	28	603	82		5,934	1,729	304	122	102	.239	.307	.327	.634
10	Giants	-77	1946	154	.396	61	93	5,191	612	1,326	176	37	121	576	530	27	546	46		5,834	1,939	334	86	121	.255	.328	.374	.701
11	Browns	-90	1946	156	.429	66	88	5,373	621	1,350	220	46	84	576	464	16	713	23	35	5,920	1,914	350	67	128	.251	.313	.356	.669
12	Senators	-98	1946	155	.494	76	78	5,337	608	1,388	260	63	60	554	512	24	638	51	50	5,959	1,954	383	86	115	.260	.328	.366	.694
13	Indians	-100	1946	156	.442	68	86	5,242	537	1,285	233	56	79	497	506	13	696	57	49	5,857	1,867	368	96	116	.245	.313	.356	.669
14	Pirates	-116	1946	155	.409	63	91	5,199	552	1,300	202	52	60	508	592	15	555	48		5,907	1,786	314	101	125	.250	.328	.344	.672
15	Phillies	-144	1946	155	.448	69	85	5,233	560	1,351	209	40	80	516	418	19	590	41		5,772	1,880	329	102	102	.258	.315	.359	.675
16	Athletics	-151	1946	155	.318	49	105	5,200	529	1,317	220	51	40	483	482	9	596	39	30	5,796	1,759	311	105	120	.253	.318	.338	.656