The Boston Red Sox had the highest run differential by a team in 1949, with a differential of 229 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	GIDP	AVG	OBP	SLG	OPS
1	Red Sox	229	1949	155	.623	96	58	5,320	896	1,500	272	36	131	835	835	17	510	43	25	6,250	2,237	439	78	169	.282	.381	.420	.802
2	Dodgers	228	1949	156	.630	97	57	5,400	879	1,477	236	47	152	816	638	33	570	117		6,173	2,263	435	102	127	.274	.354	.419	.773
3	Yankees	192	1949	155	.630	97	57	5,196	829	1,396	215	60	115	760	729	32	539	58	30	6,041	2,076	390	84	141	.269	.362	.400	.762
4	Cardinals	151	1949	157	.623	96	58	5,463	766	1,513	281	54	102	720	569	25	482	17		6,151	2,208	437	94	124	.277	.348	.404	.752
5	Indians	101	1949	154	.578	89	65	5,221	675	1,358	194	58	112	640	601	23	534	44	40	5,958	2,004	364	113	137	.260	.339	.384	.723
6	Tigers	96	1949	155	.565	87	67	5,259	751	1,405	215	51	88	707	748	23	501	39	52	6,137	1,986	354	107	164	.267	.361	.378	.739
7	Giants	45	1949	156	.474	73	81	5,308	736	1,383	203	52	147	690	613	24	523	43		6,009	2,131	402	64	125	.261	.340	.401	.741
8	Athletics	1	1949	154	.526	81	73	5,123	726	1,331	214	49	82	680	783	25	493	36	25	6,048	1,889	345	117	160	.260	.361	.369	.729
9	Phillies	-6	1949	154	.526	81	73	5,307	662	1,349	232	55	122	622	528	26	670	27		5,935	2,057	409	74	116	.254	.325	.388	.712
10	Braves	-13	1949	157	.487	75	79	5,336	706	1,376	246	33	103	654	684	23	656	28		6,139	1,997	382	96	130	.258	.345	.374	.719
11	Pirates	-84	1949	154	.461	71	83	5,214	681	1,350	191	41	126	626	548	22	554	48		5,870	2,001	358	86	96	.259	.332	.384	.716
12	White Sox	-89	1949	154	.409	63	91	5,204	648	1,340	207	66	43	591	702	13	593	62	55	6,003	1,808	316	84	136	.257	.347	.347	.695
13	Reds	-140	1949	156	.403	62	92	5,469	627	1,423	264	35	86	588	429	20	559	31		5,994	2,015	385	76	116	.260	.316	.368	.685
14	Cubs	-177	1949	154	.396	61	93	5,214	593	1,336	212	53	97	539	396	26	573	53		5,723	1,945	362	87	121	.256	.312	.373	.685
15	Browns	-247	1949	155	.344	53	101	5,112	666	1,301	213	30	117	628	631	21	700	38	39	5,847	1,925	360	83	138	.254	.339	.377	.715
16	Senators	-284	1949	154	.325	50	104	5,234	584	1,330	207	41	81	546	593	22	494	46	33	5,912	1,862	329	63	132	.254	.333	.356	.688