The New York Yankees had the highest run differential by a team in 1957, with a differential of 189 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	189	1957	154	.636	98	56	5,271	723	1,412	200	54	145	680	561	24	707	49	38	5,992	2,155	399	93	43	66	128	.268	.339	.409	.747
2	Braves	159	1957	155	.617	95	59	5,458	772	1,469	221	62	199	722	461	30	729	35	16	6,050	2,411	482	64	37	66	107	.269	.327	.442	.769
3	White Sox	141	1957	155	.584	90	64	5,265	707	1,369	208	41	106	670	632	68	744	109	51	6,082	1,977	355	75	42	33	120	.260	.344	.375	.720
4	Dodgers	99	1957	154	.545	84	70	5,242	690	1,325	188	38	147	648	550	33	848	60	34	5,944	2,030	373	78	41	46	131	.253	.325	.387	.713
5	Cardinals	71	1957	154	.565	87	67	5,472	737	1,497	235	43	132	685	493	18	672	58	44	6,082	2,214	410	45	54	75	118	.274	.333	.405	.737
6	Red Sox	53	1957	154	.532	82	72	5,267	721	1,380	231	32	153	695	622	25	736	29	21	5,993	2,134	416	41	38	55	154	.262	.341	.405	.746
7	Orioles	9	1957	154	.500	76	76	5,264	597	1,326	191	39	87	557	504	34	696	57	35	5,966	1,856	317	110	54	40	126	.252	.318	.353	.671
8	Tigers	0	1957	154	.506	78	76	5,348	614	1,376	224	37	116	574	503	27	641	36	47	6,004	2,022	377	96	30	54	127	.257	.323	.378	.701
9	Phillies	-33	1957	156	.500	77	77	5,241	623	1,311	213	44	117	569	534	45	758	57	26	5,921	1,963	374	52	49	40	143	.250	.322	.375	.697
10	Redlegs	-34	1957	154	.519	80	74	5,389	747	1,452	251	33	187	713	546	37	752	51	36	6,104	2,330	471	84	48	49	108	.269	.338	.432	.770
11	Indians	-40	1957	153	.497	76	77	5,171	682	1,304	199	26	140	649	589	26	783	40	47	5,917	1,975	365	78	53	34	109	.252	.329	.382	.711
12	Giants	-58	1957	154	.448	69	85	5,346	643	1,349	171	54	157	612	447	25	669	64	38	5,892	2,099	382	32	42	37	116	.252	.311	.393	.703
13	Cubs	-94	1957	156	.403	62	92	5,369	628	1,312	223	31	147	590	461	26	989	28	25	5,947	2,038	401	58	33	34	104	.244	.305	.380	.685
14	Pirates	-110	1957	155	.403	62	92	5,402	586	1,447	231	60	92	551	374	23	733	46	35	5,942	2,074	383	97	46	40	107	.268	.315	.384	.699
15	Athletics	-147	1957	154	.386	59	94	5,170	563	1,262	195	40	166	536	363	24	761	35	27	5,655	2,035	401	62	36	30	135	.244	.295	.394	.688
16	Senators	-205	1957	154	.357	55	99	5,231	603	1,274	215	38	111	572	527	46	731	13	38	5,895	1,898	364	50	41	41	139	.244	.316	.363	.679