The New York Yankees had the highest run differential by a team in 1958, with a differential of 182 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	182	1958	155	.597	92	62	5,294	759	1,418	212	39	164	717	537	26	818	48	32	5,971	2,200	415	72	42	39	107	.268	.336	.416	.751
2	Braves	134	1958	154	.597	92	62	5,225	675	1,388	221	21	167	641	478	36	646	26	8	5,859	2,152	409	79	41	68	132	.266	.329	.412	.741
3	Redlegs	74	1958	154	.494	76	78	5,273	695	1,359	242	40	123	649	572	21	765	61	38	5,980	2,050	405	76	38	41	109	.258	.331	.389	.719
4	Indians	59	1958	153	.503	77	76	5,201	694	1,340	210	31	161	653	494	40	819	50	49	5,840	2,095	402	69	36	29	112	.258	.325	.403	.728
5	Pirates	55	1958	154	.545	84	70	5,247	662	1,386	229	68	134	625	396	28	753	30	15	5,779	2,153	431	68	40	56	128	.264	.317	.410	.727
6	Tigers	53	1958	154	.500	77	77	5,194	659	1,384	229	41	109	611	463	22	678	48	32	5,805	2,022	379	75	51	37	127	.266	.326	.389	.715
7	Giants	29	1958	154	.519	80	74	5,318	727	1,399	250	42	170	682	531	34	817	64	29	5,996	2,243	462	68	45	54	119	.263	.331	.422	.753
8	White Sox	19	1958	155	.532	82	72	5,249	634	1,348	191	42	101	594	518	49	669	101	33	5,935	1,926	334	72	47	30	120	.257	.327	.367	.694
9	Red Sox	6	1958	155	.513	79	75	5,218	697	1,335	229	30	155	667	638	27	820	29	22	5,972	2,089	414	60	29	38	149	.256	.338	.400	.739
10	Cubs	-16	1958	154	.468	72	82	5,289	709	1,402	207	49	182	666	487	45	853	39	23	5,902	2,253	438	42	39	50	128	.265	.330	.426	.756
11	Orioles	-54	1958	154	.484	74	79	5,111	521	1,233	195	19	108	492	483	28	731	33	35	5,720	1,790	322	62	36	31	134	.241	.308	.350	.658
12	Athletics	-71	1958	156	.474	73	81	5,261	642	1,297	196	50	138	605	452	25	747	22	36	5,845	2,007	384	64	43	34	133	.247	.307	.381	.688
13	Cardinals	-85	1958	154	.468	72	82	5,255	619	1,371	216	39	111	570	533	20	637	44	43	5,891	1,998	366	44	39	69	166	.261	.329	.380	.709
14	Dodgers	-93	1958	154	.461	71	83	5,173	668	1,297	166	50	172	627	495	25	850	73	47	5,804	2,079	388	68	43	22	132	.251	.317	.402	.719
15	Phillies	-98	1958	154	.448	69	85	5,363	664	1,424	238	56	124	630	573	38	871	51	33	6,081	2,146	418	70	37	60	133	.266	.339	.400	.739
16	Senators	-194	1958	156	.396	61	93	5,156	553	1,240	161	38	121	526	477	35	751	22	41	5,763	1,840	320	57	38	21	133	.240	.307	.357	.664