The Pittsburgh Pirates had the highest run differential by a team in 1960, with a differential of 141 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Pirates	141	1960	155	.617	95	59	5,406	734	1,493	236	56	120	689	486	20	747	34	24	6,029	2,201	412	69	48	71	119	.276	.335	.407	.743
2	White Sox	124	1960	154	.565	87	67	5,191	741	1,402	242	38	112	684	567	54	648	122	48	5,966	2,056	392	95	59	36	133	.270	.345	.396	.741
3	Yankees	119	1960	155	.630	97	57	5,290	746	1,377	215	40	193	699	537	28	818	37	23	5,981	2,251	448	81	45	41	112	.260	.329	.426	.755
4	Orioles	76	1960	154	.578	89	65	5,170	682	1,307	206	33	123	640	596	36	800	37	24	5,911	1,948	362	72	37	36	127	.253	.332	.377	.709
5	Dodgers	69	1960	154	.532	82	72	5,227	662	1,333	216	38	126	606	529	27	837	95	53	5,935	2,003	380	102	50	46	108	.255	.324	.383	.707
6	Braves	66	1960	154	.571	88	66	5,263	724	1,393	198	48	170	681	463	23	793	69	37	5,868	2,197	416	59	60	53	101	.265	.323	.417	.741
7	Giants	40	1960	156	.513	79	75	5,324	671	1,357	220	62	130	622	467	33	846	86	45	5,923	2,091	412	60	39	61	106	.255	.317	.393	.709
8	Cardinals	23	1960	155	.558	86	68	5,187	639	1,317	213	48	138	592	501	31	792	48	35	5,806	2,040	399	52	35	63	118	.254	.321	.393	.715
9	Tigers	-11	1960	154	.461	71	83	5,202	633	1,243	188	34	150	601	636	33	728	66	32	5,990	1,949	372	85	34	31	117	.239	.324	.375	.698
10	Senators	-24	1960	154	.474	73	81	5,248	672	1,283	205	43	147	626	584	48	883	52	43	6,004	2,015	395	86	38	42	130	.244	.324	.384	.708
11	Indians	-26	1960	154	.494	76	78	5,296	667	1,415	218	20	127	632	444	32	571	58	25	5,921	2,054	365	97	52	41	113	.267	.325	.388	.713
12	Reds	-52	1960	154	.435	67	87	5,289	640	1,324	230	40	140	604	512	34	858	73	37	5,940	2,054	410	60	45	44	110	.250	.318	.388	.706
13	Red Sox	-117	1960	154	.422	65	89	5,215	658	1,359	234	32	124	623	570	25	799	34	28	5,931	2,029	390	70	51	33	153	.261	.333	.389	.722
14	Athletics	-141	1960	155	.377	58	96	5,226	615	1,303	212	34	110	566	513	12	744	16	11	5,858	1,913	356	75	32	22	154	.249	.316	.366	.682
15	Cubs	-142	1960	156	.390	60	94	5,311	634	1,293	213	48	119	600	531	19	897	51	34	5,960	1,959	380	64	35	69	109	.243	.313	.369	.681
16	Phillies	-145	1960	154	.383	59	95	5,169	546	1,235	196	44	99	503	448	33	1,054	45	48	5,748	1,816	339	66	32	40	104	.239	.302	.351	.653