The New York Yankees had the highest run differential by a team in 1964, with a differential of 153 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	153	1964	164	.611	99	63	5,705	730	1,442	208	35	162	688	520	31	976	54	18	6,358	2,206	405	68	34	64	117	.253	.317	.387	.704
2	White Sox	141	1964	162	.605	98	64	5,491	642	1,356	184	40	106	586	562	52	902	75	39	6,246	1,938	330	96	45	58	100	.247	.320	.353	.673
3	Orioles	112	1964	163	.599	97	65	5,463	679	1,357	229	20	162	632	537	27	1,019	78	38	6,143	2,112	411	69	47	55	126	.248	.316	.387	.703
4	Reds	94	1964	163	.568	92	70	5,561	660	1,383	220	38	130	605	457	33	974	90	36	6,153	2,069	388	65	37	64	105	.249	.308	.372	.680
5	Giants	69	1964	162	.556	90	72	5,535	656	1,360	185	38	165	608	505	33	900	64	35	6,194	2,116	388	78	43	74	118	.246	.310	.382	.693
6	Cardinals	63	1964	162	.574	93	69	5,625	715	1,531	240	53	109	654	427	18	925	73	51	6,196	2,204	402	94	32	51	96	.272	.324	.392	.716
7	Phillies	61	1964	162	.568	92	70	5,493	693	1,415	241	51	130	649	440	40	924	30	35	6,116	2,148	422	97	46	61	108	.258	.315	.391	.706
8	Braves	59	1964	162	.543	88	74	5,591	803	1,522	274	32	159	755	486	38	825	53	41	6,206	2,337	465	54	37	54	134	.272	.333	.418	.751
9	Twins	59	1964	163	.488	79	83	5,610	737	1,413	227	46	221	707	553	44	1,019	46	22	6,318	2,395	494	74	37	43	120	.252	.322	.427	.749
10	Dodgers	42	1964	164	.494	80	82	5,499	614	1,375	180	39	79	555	438	19	893	141	60	6,120	1,870	298	120	44	55	105	.250	.305	.340	.645
11	Pirates	27	1964	162	.494	80	82	5,566	663	1,469	225	54	121	630	408	24	970	39	33	6,119	2,165	400	87	34	55	127	.264	.315	.389	.704
12	Tigers	21	1964	163	.525	85	77	5,513	699	1,394	199	57	157	658	517	40	912	60	27	6,183	2,178	413	71	42	40	105	.253	.319	.395	.714
13	Indians	-4	1964	164	.488	79	83	5,603	689	1,386	208	22	164	640	500	49	1,063	79	51	6,257	2,130	394	63	42	63	112	.247	.312	.380	.693
14	Angels	-7	1964	162	.506	82	80	5,362	544	1,297	186	27	102	508	472	26	920	49	39	5,975	1,843	315	78	37	40	145	.242	.304	.344	.648
15	Cubs	-75	1964	162	.469	76	86	5,545	649	1,391	239	50	145	609	499	25	1,041	70	49	6,157	2,165	434	55	33	51	101	.251	.314	.390	.704
16	Red Sox	-105	1964	162	.444	72	90	5,513	688	1,425	253	29	186	648	504	28	917	18	16	6,106	2,294	468	35	26	43	144	.258	.322	.416	.738
17	Colt .45's	-133	1964	162	.407	66	96	5,303	495	1,214	162	41	70	452	381	49	872	40	48	5,859	1,668	273	87	39	44	113	.229	.285	.315	.599
18	Senators	-155	1964	162	.383	62	100	5,396	578	1,246	199	28	125	528	514	28	1,124	47	30	6,037	1,876	352	66	33	34	119	.231	.299	.348	.647
19	Mets	-207	1964	163	.327	53	109	5,566	569	1,372	195	31	103	527	353	48	932	36	31	6,045	1,938	329	52	26	34	147	.246	.296	.348	.644
20	Athletics	-215	1964	163	.352	57	105	5,524	621	1,321	216	29	166	594	548	42	1,104	34	20	6,192	2,093	411	53	25	32	152	.239	.311	.379	.690