The New York Yankees had the highest run differential by a team in 1985, with a differential of 179 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	179	1985	161	.602	97	64	5,458	839	1,458	272	31	176	793	620	50	771	155	53	6,236	2,320	479	48	60	50	119	.267	.344	.425	.769
2	Cardinals	175	1985	162	.623	101	61	5,467	747	1,446	245	59	87	687	586	18	853	314	96	6,182	2,070	391	70	41	61	91	.264	.335	.379	.714
3	Blue Jays	171	1985	161	.615	99	62	5,508	759	1,482	281	53	158	714	503	30	807	144	77	6,106	2,343	492	21	44	44	121	.269	.331	.425	.757
4	Mets	127	1985	162	.605	98	64	5,549	695	1,425	239	35	134	651	546	20	872	117	53	6,248	2,136	408	89	44	88	131	.257	.323	.385	.708
5	Dodgers	103	1985	162	.586	95	67	5,502	682	1,434	226	28	129	632	539	31	846	136	58	6,222	2,103	383	104	46	69	108	.261	.328	.382	.710
6	Red Sox	80	1985	163	.500	81	81	5,720	800	1,615	292	31	162	760	562	30	816	66	27	6,419	2,455	485	50	57	39	164	.282	.347	.429	.776
7	Orioles	54	1985	161	.516	83	78	5,517	818	1,451	234	22	214	773	604	19	908	69	43	6,211	2,371	470	31	40	30	132	.263	.336	.430	.765
8	Royals	48	1985	162	.562	91	71	5,500	687	1,384	261	49	154	657	473	36	840	128	48	6,094	2,205	464	44	41	57	125	.252	.313	.401	.714
9	Tigers	41	1985	161	.522	84	77	5,575	729	1,413	254	45	202	703	526	27	926	75	41	6,221	2,363	501	40	53	56	81	.253	.318	.424	.742
10	Angels	29	1985	162	.556	90	72	5,442	732	1,364	215	31	153	685	648	39	902	106	51	6,263	2,100	399	99	35	51	138	.251	.333	.386	.719
11	Padres	28	1985	162	.512	83	79	5,507	650	1,405	241	28	109	611	513	23	809	60	39	6,150	2,029	378	75	32	68	128	.255	.320	.368	.688
12	White Sox	16	1985	163	.525	85	77	5,470	736	1,386	247	37	146	695	471	43	843	108	56	6,088	2,145	430	59	45	40	119	.253	.315	.392	.707
13	Astros	15	1985	162	.512	83	79	5,582	706	1,457	261	42	121	666	477	23	873	96	56	6,192	2,165	424	66	44	63	127	.261	.319	.388	.707
14	Reds	11	1985	162	.553	89	72	5,431	677	1,385	249	34	114	634	576	23	856	159	70	6,143	2,044	397	72	41	72	136	.255	.327	.376	.703
15	Expos	-3	1985	161	.522	84	77	5,429	633	1,342	242	49	118	593	492	26	880	169	77	6,053	2,036	409	61	45	73	112	.247	.310	.375	.685
16	Phillies	-6	1985	162	.463	75	87	5,477	667	1,343	238	47	141	628	527	25	1,095	122	51	6,122	2,098	426	49	44	51	124	.245	.312	.383	.695
17	Athletics	-30	1985	162	.475	77	85	5,581	757	1,475	230	34	155	690	508	16	861	117	58	6,215	2,238	419	63	47	29	128	.264	.325	.401	.726
18	Cubs	-43	1985	162	.478	77	84	5,492	686	1,397	239	28	150	640	562	18	937	182	49	6,177	2,142	417	66	39	62	119	.254	.324	.390	.714
19	Twins	-77	1985	162	.475	77	85	5,509	705	1,453	282	41	141	678	502	31	779	68	44	6,128	2,240	464	39	47	36	117	.264	.326	.407	.733
20	Mariners	-99	1985	162	.457	74	88	5,521	719	1,410	277	38	171	686	564	31	942	94	35	6,185	2,276	486	28	41	36	147	.255	.326	.412	.738
21	Brewers	-112	1985	161	.441	71	90	5,568	690	1,467	250	44	101	636	462	19	746	69	34	6,158	2,108	395	54	55	33	145	.263	.319	.379	.698
22	Giants	-118	1985	162	.383	62	100	5,420	556	1,263	217	31	115	517	488	37	962	99	55	6,063	1,887	363	93	25	53	121	.233	.299	.348	.648
23	Indians	-132	1985	162	.370	60	102	5,527	729	1,465	254	31	116	689	492	15	817	132	72	6,120	2,129	401	38	48	26	139	.265	.324	.385	.709
24	Pirates	-140	1985	161	.354	57	104	5,436	568	1,340	251	28	80	535	514	14	842	110	60	6,099	1,887	359	91	44	64	131	.247	.311	.347	.658
25	Braves	-149	1985	162	.407	66	96	5,526	632	1,359	213	28	126	598	553	22	849	72	52	6,207	2,006	367	65	41	56	154	.246	.315	.363	.678