The Colorado Rockies have the lowest run differential by a team this season, with a differential of -197 runs.

Interpreted as:

the worst differential in the MLB this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	-197	2025	73	.219	16	57	2,431	255	548	114	24	71	251	201	29	710	35	17	2,683	923	209	7	15	5	53	.225	.291	.380	.670
2	Athletics	-111	2025	74	.405	30	44	2,534	315	642	125	8	92	306	238	17	609	41	9	2,807	1,059	225	4	14	5	66	.253	.320	.418	.738
3	Marlins	-86	2025	71	.408	29	42	2,430	292	614	115	10	63	281	212	18	572	56	24	2,694	938	188	14	20	5	42	.253	.315	.386	.701
4	Orioles	-75	2025	72	.431	31	41	2,398	285	579	105	9	83	266	202	30	637	52	15	2,653	951	197	2	21	6	59	.241	.306	.397	.703
5	White Sox	-72	2025	73	.315	23	50	2,384	250	529	113	4	55	240	235	14	633	51	15	2,663	815	172	10	20	3	41	.222	.293	.342	.635
6	Nationals	-69	2025	73	.411	30	43	2,422	305	580	120	10	70	289	207	37	547	61	24	2,691	930	200	10	15	3	48	.239	.307	.384	.691
7	Pirates	-58	2025	74	.392	29	45	2,434	235	546	91	13	50	225	244	28	638	68	22	2,726	813	154	6	14	10	66	.224	.301	.334	.635
8	Angels	-57	2025	72	.486	35	37	2,395	297	540	96	8	100	286	180	34	702	34	13	2,633	952	204	7	17	9	42	.225	.287	.397	.685
9	Guardians	-26	2025	70	.500	35	35	2,278	270	528	95	6	72	255	220	27	570	56	16	2,558	851	173	9	24	10	46	.232	.304	.374	.678
10	Royals	-23	2025	73	.479	35	38	2,455	243	612	118	14	49	239	170	24	503	57	24	2,688	905	181	16	23	10	37	.249	.302	.369	.670
11	Blue Jays	-11	2025	72	.542	39	33	2,428	307	617	124	3	73	295	231	26	494	38	11	2,724	966	200	16	23	12	54	.254	.323	.398	.721
12	Diamondbacks	-6	2025	72	.500	36	36	2,435	365	615	130	15	102	357	265	33	559	54	16	2,771	1,081	247	12	26	9	49	.253	.331	.444	.775
13	Mariners	-4	2025	71	.507	36	35	2,421	308	585	93	4	90	298	258	37	633	72	20	2,741	956	187	11	14	7	42	.242	.322	.395	.717
14	Twins	6	2025	72	.500	36	36	2,422	300	585	113	8	76	288	209	45	602	36	14	2,692	942	197	1	15	4	48	.242	.312	.389	.701
15	Braves	13	2025	71	.451	32	39	2,409	295	590	97	6	76	284	243	22	609	37	12	2,697	927	179	7	16	8	47	.245	.318	.385	.703
16	Brewers	19	2025	74	.527	39	35	2,454	319	581	102	8	66	295	251	31	613	90	22	2,770	897	176	16	18	8	36	.237	.313	.366	.679
17	Rangers	22	2025	73	.493	36	37	2,388	266	544	98	6	76	257	201	27	593	62	17	2,638	882	180	3	19	6	36	.228	.293	.369	.662
18	Padres	22	2025	71	.549	39	32	2,368	298	587	105	10	61	275	223	17	503	53	14	2,647	895	176	17	22	7	45	.248	.314	.378	.692
19	Red Sox	24	2025	74	.514	38	36	2,563	355	646	141	11	90	340	256	34	687	62	15	2,874	1,079	242	6	15	15	41	.252	.326	.421	.747
20	Cardinals	28	2025	73	.521	38	35	2,483	340	637	127	4	68	322	233	39	567	40	13	2,784	976	199	9	20	10	55	.257	.328	.393	.721
21	Phillies	31	2025	73	.589	43	30	2,485	342	638	114	11	78	326	255	28	569	63	14	2,791	1,008	203	7	16	9	44	.257	.331	.406	.736
22	Astros	37	2025	72	.569	41	31	2,393	293	606	105	7	70	280	203	30	553	43	14	2,655	935	182	9	20	6	61	.253	.317	.391	.708
23	Reds	42	2025	73	.521	38	35	2,454	341	606	122	7	82	328	259	23	638	61	22	2,760	988	211	6	18	7	44	.247	.322	.403	.725
24	Giants	45	2025	72	.569	41	31	2,369	309	551	108	12	70	294	257	25	609	42	15	2,685	893	190	12	22	6	46	.233	.312	.377	.689
25	Rays	64	2025	73	.548	40	33	2,447	333	612	116	4	77	316	225	24	615	97	22	2,722	967	197	6	20	3	48	.250	.317	.395	.712