The Detroit Tigers had their highest run differential in a game versus the Cleveland Blues on September 15, 1901, with a differential of 21 runs.

Interpreted as:

tigers record in 1 or more run differentials in a regular-season game

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Tigers	21	9/15/1901	DET	vs	CLE	W 21-0	42	21	24	8	0	1	20	3	2	1	1	-10	49	35	9	2		-10	-10	.571	.617	.833	1.450
2	Tigers	19	9/5/1924	DET	vs	CLE	W 20-1	42	20	21	3	2	0	20	5	1	4	4	1	51	28	5	3				.500	.563	.667	1.229
3	Tigers	19	7/17/1908	DET	@	PHA	W 21-2	50	21	27	9	3	0	18	7	0	8	5		59	42	12	2				.540	.596	.840	1.436
4	Tigers	18	4/29/1935	DET	@	SLA	W 18-0	43	18	15	5	2	2	16	8	0	6	1	0	51	30	9	0				.349	.451	.698	1.149
5	Tigers	18	6/5/1934	DET	vs	CLE	W 20-2	45	20	21	9	1	1	18	2	1	4	2	1	49	35	11	1				.467	.500	.778	1.278
6	Tigers	18	6/17/1925	DET	@	NYY	W 19-1	44	19	18	2	2	2	14	7	0	2	0	1	52	30	6	1				.409	.490	.682	1.172
7	Tigers	18	6/29/1917	DET	@	SLA	W 19-1	41	19	19	2	2	2		9	0	4	4		54	31	6	4				.463	.560	.756	1.316
8	Tigers	17	4/29/2006	DET	vs	MIN	W 18-1	48	18	23	6	0	4	15	2	1	10	1	0	51	41	10	0	0	0	0	.479	.510	.854	1.364
9	Tigers	17	4/17/1993	DET	vs	SEA	W 20-3	43	20	20	2	1	2	20	10	1	7	3	1	54	30	5	0	0	1	0	.465	.574	.698	1.272
10	Tigers	17	7/19/1991	DET	@	KCR	W 17-0	42	17	16	4	1	1	15	8	0	13	0	0	52	25	6	0	2	0	0	.381	.462	.595	1.057
11	Tigers	17	6/30/1935	DET	@	SLA	W 18-1	45	18	19	4	2	1	18	5	1	1	0	0	51	30	7	0				.422	.490	.667	1.157
12	Tigers	17	7/19/1924	DET	@	BSA	W 18-1	42	18	21	5	1	1	16	5	0	5	0	2	50	31	7	3				.500	.553	.738	1.291
13	Tigers	17	8/8/1908	DET	vs	WSH	W 18-1	44	18	22	5	1	0	15	3	0		2		49	29	6	2				.500	.532	.659	1.191
14	Tigers	16	9/4/2011	DET	vs	CWS	W 18-2	48	18	24	5	0	2	17	3	1	12	0	0	52	35	7	0	0	0	0	.500	.538	.729	1.268
15	Tigers	16	5/24/2008	DET	vs	MIN	W 19-3	42	19	17	3	0	2	17	5	0	5	0	0	48	26	5	1	0	0	0	.405	.468	.619	1.087
16	Tigers	16	8/27/2007	DET	vs	NYY	W 16-0	43	16	20	6	1	1	15	7	1	5	1	0	52	31	8	0	1	0	1	.465	.538	.721	1.259
17	Tigers	16	5/18/2001	DET	@	TBD	W 18-2	46	18	19	3	2	1	18	4	1	10	2	0	52	29	6	0	1	0	1	.413	.462	.630	1.092
18	Tigers	16	4/24/1993	DET	@	MIN	W 17-1	45	17	18	4	0	5	16	4	0	9	0	0	50	37	9	0	1	0	0	.400	.440	.822	1.262
19	Tigers	16	4/13/1993	DET	vs	OAK	W 20-4	43	20	18	2	0	3	18	12	1	10	1	0	56	29	5	0	0	0	0	.419	.554	.674	1.228
20	Tigers	16	4/18/1991	DET	@	CWS	W 16-0	46	16	19	2	1	4	16	5	0	6	3	0	51	35	7	0	0	0	1	.413	.471	.761	1.231
21	Tigers	16	7/15/1982	DET	@	MIN	W 18-2	47	18	19	8	0	3	18	5	0	7	0	0	53	36	11	0	1	0	1	.404	.453	.766	1.219
22	Tigers	16	9/4/1955	DET	@	KCA	W 17-1	47	17	20	2	0	3	13	8	0	1	1	0	56	31	5	1	0	0	1	.426	.509	.660	1.169
23	Tigers	16	4/17/1955	DET	vs	KCA	W 16-0	39	16	15	3	0	4	16	9	0	5	1	0	49	30	7	0	1	0	0	.385	.490	.769	1.259
24	Tigers	16	8/14/1935	DET	vs	WSH	W 18-2	40	18	17	4	2	0	16	7	1	2	1	0	49	25	6	1				.425	.521	.625	1.146
25	Tigers	15	5/4/2013	DET	@	HOU	W 17-2	48	17	21	4	1	3	17	5	0	4	1	0	53	36	8	0	0	0	0	.438	.491	.750	1.241