Nolan Ryan has struck out the most career hitters with an ERA worse than 0.00, with 5,714 strikeouts.

	NAME	SO	ERA	G	W	L	W%	GS	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Nolan Ryan N. Ryan	5,714	3.19	807	324	292	.526	773	222	61	3	5386.0	3,923	1,911	2,178	321	2,795	158	13	78	22,575	277	9.55	4.67	2.04	0.54	25.3	12.4	1.25	.265	3.64	90	2.96	83	6.56	370.2
2	Randy Johnson R. Johnson	4,875	3.29	618	303	166	.646	603	100	37	2	4135.1	3,346	1,513	1,703	411	1,497	190	7	37	17,067	109	10.61	3.26	3.26	0.89	28.6	8.8	1.17	.291	3.71	75	3.18	73	7.28	554.3
3	Roger Clemens R. Clemens	4,672	3.12	709	354	184	.658	707	118	46	0	4916.2	4,185	1,707	1,885	363	1,580	159	0	63	20,240	143	8.55	2.89	2.96	0.66	23.1	7.8	1.17	.284	3.45	70	3.08	71	7.66	680.4
4	Steve Carlton S. Carlton	4,136	3.22	741	329	244	.574	709	254	55	2	5217.2	4,672	1,864	2,130	414	1,833	53	13	150	21,683	183	7.13	3.16	2.26	0.71	19.1	8.5	1.25	.279	3.67	87	3.14	86	8.06	271.5
5	Bert Blyleven B. Blyleven	3,701	3.31	692	287	250	.534	685	242	60	0	4970.0	4,632	1,830	2,029	430	1,322	155	3	71	20,491	114	6.70	2.39	2.80	0.78	18.1	6.5	1.20	.282	3.67	85	3.18	82	8.39	368.6
6	Tom Seaver T. Seaver	3,640	2.86	656	311	205	.603	647	231	61	1	4783.0	3,971	1,521	1,674	380	1,390	76	6	116	19,369	126	6.85	2.62	2.62	0.72	18.8	7.2	1.12	.259	3.15	79	3.03	85	7.47	286.1
7	Don Sutton D. Sutton	3,574	3.26	774	324	256	.559	756	178	58	5	5282.1	4,692	1,914	2,104	472	1,343	82	12	102	21,631	112	6.09	2.29	2.66	0.80	16.5	6.2	1.14	.261	3.58	92	3.23	90	7.99	181.2
8	Justin Verlander J. Verlander	3,553	3.32	555	266	158	.627	555	26	9	0	3567.2	3,046	1,317	1,428	371	1,004	121	0	28	14,607	99	8.96	2.53	3.54	0.94	24.3	6.9	1.14	.280	3.60	79	3.43	81	7.68	310.9
9	Gaylord Perry G. Perry	3,534	3.11	777	314	265	.542	690	303	53	10	5350.0	4,938	1,846	2,128	399	1,379	108	33	164	21,953	160	5.95	2.32	2.56	0.67	16.1	6.3	1.18	.275	3.58	85	3.06	85	8.31	312.9
10	Walter Johnson W. Johnson	3,509	2.17	802	417	279	.599	666	531	110	34	5914.1	4,913	1,424	1,902	97	1,363	205	127		23,405	154	5.34	2.07	2.57	0.15	15.0	5.8	1.06	.264	2.89	68	2.42	76	7.48	472.8
11	Max Scherzer M. Scherzer	3,489	3.22	483	220	117	.653	474	12	5	0	2963.0	2,433	1,059	1,132	354	779	114	2	20	11,987	80	10.60	2.37	4.48	1.08	29.1	6.5	1.08	.287	3.44	77	3.23	78	7.39	302.5
12	Greg Maddux G. Maddux	3,371	3.16	744	355	227	.610	740	109	35	0	5008.1	4,726	1,756	1,981	353	999	137	3	177	20,421	70	6.06	1.80	3.37	0.63	16.5	4.9	1.14	.281	3.56	76	3.25	78	8.49	519.5
13	Phil Niekro P. Niekro	3,342	3.35	864	318	274	.537	716	245	45	29	5404.0	5,044	2,012	2,337	482	1,809	123	83	86	22,677	226	5.57	3.01	1.85	0.80	14.7	8.0	1.27	.270	3.89	87	3.61	95	8.40	116.1
14	Fergie Jenkins F. Jenkins	3,192	3.34	664	284	226	.557	594	267	49	7	4500.2	4,142	1,669	1,853	484	997	84	37	116	18,400	62	6.38	1.99	3.20	0.97	17.3	5.4	1.14	.268	3.71	87	3.27	88	8.28	222.9
15	Pedro Martinez P. Martinez	3,154	2.93	476	219	100	.687	409	46	17	3	2827.1	2,221	919	1,006	239	760	141	23	30	11,394	62	10.04	2.42	4.15	0.76	27.7	6.7	1.05	.279	3.20	66	2.91	68	7.07	454.6
16	Bob Gibson B. Gibson	3,117	2.91	528	251	174	.591	482	255	56	6	3884.1	3,279	1,258	1,420	257	1,336	102	21	118	16,068	108	7.22	3.10	2.33	0.60	19.4	8.3	1.19	.268	3.29	78	2.89	81	7.60	290.5
17	Curt Schilling C. Schilling	3,116	3.46	569	216	146	.597	436	83	20	22	3261.0	2,998	1,253	1,318	347	711	52	81	43	13,284	72	8.60	1.96	4.38	0.96	23.5	5.4	1.14	.293	3.64	80	3.22	76	8.27	373.6
18	CC Sabathia	3,093	3.74	561	251	161	.609	560	38	12	0	3577.1	3,404	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
19	John Smoltz J. Smoltz	3,084	3.33	723	213	155	.579	481	53	16	154	3473.0	3,074	1,284	1,391	288	1,010	57	204	84	14,271	145	7.99	2.62	3.05	0.75	21.6	7.1	1.18	.283	3.60	81	3.23	78	7.97	356.6
20	Clayton Kershaw C. Kershaw	3,052	2.53	455	223	96	.699	451	25	15	0	2855.1	2,193	804	881	235	713	46	1	28	11,279	108	9.62	2.25	4.28	0.74	27.1	6.3	1.02	.271	2.78	65	2.85	70	6.91	375.1
21	Zack Greinke Z. Greinke	2,979	3.49	586	225	156	.591	541	17	5	1	3389.1	3,207	1,315	1,410	367	762	79	8	25	13,877	101	7.91	2.02	3.91	0.97	21.5	5.5	1.17	.293	3.74	83	3.51	85	8.52	235
22	Jim Bunning J. Bunning	2,855	3.27	591	224	184	.549	519	151	40	16	3760.1	3,433	1,366	1,527	372	1,000	160	39	98	15,618	47	6.83	2.39	2.86	0.89	18.3	6.4	1.18	.273	3.65	88	3.22	88	8.22	195.2
23	Mickey Lolich M. Lolich	2,832	3.44	586	217	191	.532	496	195	41	10	3638.1	3,366	1,390	1,537	347	1,099	92	40	67	15,140	124	7.01	2.72	2.58	0.86	18.7	7.3	1.23	.280	3.80	96	3.19	87	8.33	188.5
24	Mike Mussina M. Mussina	2,813	3.68	537	270	153	.638	536	57	23	0	3562.2	3,460	1,458	1,559	376	785	60	0	29	14,593	71	7.11	1.98	3.58	0.95	19.3	5.4	1.19	.292	3.94	82	3.57	79	8.74	372.8
25	Cy Young C. Young	2,803	2.63	906	511	316	.618	815	749	76	17	7356.0	7,092	2,147	3,167	138	1,217	161	84		29,565	156	3.43	1.49	2.30	0.17	9.5	4.1	1.13	.275	3.87	74	2.84	79	8.68	620