The New York Yankees have the highest run differential by a team this season, with a differential of 113 runs.

Interpreted as:

top run differential this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	113	2025	55	.636	35	20	1,868	305	484	103	10	88	293	225	26	486	39	12	2,144	871	201	1	24	16	34	.259	.343	.466	.809
2	Cubs	95	2025	56	.625	35	21	1,956	330	512	105	13	79	322	212	14	441	72	12	2,207	880	197	6	19	7	25	.262	.335	.450	.785
3	Tigers	84	2025	57	.649	37	20	1,925	288	485	90	8	65	275	190	26	510	20	5	2,161	786	163	4	16	5	34	.252	.325	.408	.733
4	Dodgers	65	2025	56	.607	34	22	1,909	314	503	93	9	87	301	216	20	464	38	11	2,167	875	189	3	19	11	43	.263	.341	.458	.800
5	Mets	57	2025	56	.607	34	22	1,854	243	455	96	12	58	234	207	36	432	42	8	2,122	749	166	3	22	12	47	.245	.329	.404	.733
6	Cardinals	45	2025	56	.571	32	24	1,906	269	500	106	4	52	255	183	26	436	35	11	2,138	770	162	6	17	9	43	.262	.333	.404	.737
7	Giants	39	2025	56	.554	31	25	1,845	242	427	84	8	55	231	195	16	473	26	12	2,077	692	147	9	12	4	36	.231	.309	.375	.684
8	Phillies	39	2025	56	.643	36	20	1,915	270	497	87	8	60	256	212	21	446	53	11	2,168	780	155	5	15	6	36	.260	.337	.407	.745
9	Reds	32	2025	57	.491	28	29	1,924	264	478	100	7	58	252	199	20	508	54	19	2,158	766	165	3	12	5	32	.248	.323	.398	.722
10	Rays	30	2025	56	.518	29	27	1,872	239	462	85	3	54	229	170	16	463	81	15	2,076	715	142	1	17	0	38	.247	.312	.382	.694
11	Twins	26	2025	55	.545	30	25	1,823	216	431	86	7	51	206	150	34	449	29	11	2,020	684	144	1	12	4	36	.236	.305	.375	.680
12	Astros	26	2025	56	.536	30	26	1,864	233	476	79	6	56	223	167	27	424	27	13	2,081	735	141	8	15	6	45	.255	.323	.394	.718
13	Padres	18	2025	54	.574	31	23	1,804	233	457	79	7	52	213	169	13	379	41	11	2,014	706	138	12	16	6	34	.253	.319	.391	.711
14	Braves	14	2025	55	.473	26	29	1,869	229	463	78	6	59	220	191	16	465	33	11	2,093	730	143	6	11	4	35	.248	.321	.391	.712
15	Red Sox	12	2025	58	.466	27	31	2,016	275	509	106	8	71	263	197	24	522	54	13	2,253	844	185	5	11	12	27	.252	.325	.419	.743
16	Mariners	12	2025	55	.545	30	25	1,864	250	442	68	3	73	241	213	31	492	53	17	2,127	735	144	8	11	3	32	.237	.324	.394	.718
17	Brewers	1	2025	57	.509	29	28	1,890	246	438	76	5	48	225	199	24	464	74	17	2,140	668	129	14	13	8	27	.232	.311	.353	.664
18	Royals	-5	2025	57	.526	30	27	1,905	188	469	97	11	33	185	136	21	398	47	20	2,095	687	141	13	20	8	25	.246	.301	.361	.661
19	Diamondbacks	-6	2025	56	.482	27	29	1,904	279	484	110	11	77	272	202	27	423	49	11	2,164	847	198	8	23	7	37	.254	.331	.445	.776
20	Rangers	-12	2025	57	.474	27	30	1,835	185	403	67	5	57	180	145	19	459	50	13	2,015	651	129	2	14	3	27	.220	.282	.355	.636
21	Blue Jays	-14	2025	56	.500	28	28	1,879	221	466	93	2	51	212	191	20	401	34	9	2,121	716	146	13	18	10	41	.248	.321	.381	.702
22	Guardians	-17	2025	55	.545	30	25	1,795	223	419	79	5	57	211	173	21	443	39	14	2,019	679	141	8	22	7	30	.233	.305	.378	.683
23	Nationals	-41	2025	56	.464	26	30	1,860	244	450	92	8	58	231	162	26	437	54	18	2,071	732	158	10	13	2	34	.242	.310	.394	.703
24	White Sox	-48	2025	56	.321	18	38	1,826	196	404	83	2	46	190	181	12	470	45	9	2,039	629	131	6	14	1	30	.221	.294	.344	.638
25	Angels	-56	2025	55	.455	25	30	1,820	224	408	78	6	79	217	136	23	542	24	8	1,998	735	163	5	14	6	31	.224	.284	.404	.688