The Washington Senators had their most runs in a game versus the New York Highlanders on June 28, 1907, with 16 runs.

Interpreted as:

twins most runs in a regular-season game vs yankees

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Senators	16	6/28/1907	WSH	@	NYH	W 16-5	45	19	0	2	1	14	9	0	4	13		56	26	3	2				.422	.519	.578	1.096
2	Senators	15	7/1/1907	WSH	@	NYH	L 15-16	44	19	3	0	1	13	3	1	3	3		48	25	4	0				.432	.479	.568	1.047
3	Senators	14	9/5/1930	WSH	@	NYY	W 14-5	40	15	4	2	0	13	6	0	2	1	0	50	23	6	4				.375	.457	.575	1.032
4	Senators	14	5/2/1914	WSH	vs	NYY	W 14-1	35	13	5	1	1	14	5	0	5	0		43	23	7	3				.371	.450	.657	1.107
5	Twins	13	5/18/1994	MIN	vs	NYY	W 13-5	43	17	7	2	1	11	4	0	6	0	0	47	31	10	0	0	0	0	.395	.447	.721	1.168
6	Twins	13	5/2/1967	MIN	vs	NYY	W 13-4	34	13	4	2	0	11	6	0	4	0	0	44	21	6	1	3	1	1	.382	.442	.618	1.060
7	Senators	13	5/30/1958	WSH	@	NYY	W 13-8	41	14	1	2	2	13	6	1	6	0	1	49	25	5	1	0	0	0	.341	.438	.610	1.047
8	Senators	13	8/10/1936	WSH	@	NYY	W 13-4	43	18	3	2	1	13	7	0	2	1	1	51	28	6	1				.419	.500	.651	1.151
9	Senators	13	5/28/1932	WSH	vs	NYY	W 13-5	39	15	6	0	1	12	2	1	3	0	0	43	24	7	1				.385	.429	.615	1.044
10	Senators	13	8/6/1929	WSH	@	NYY	W 13-9	42	14	3	0	2	12	5	0	4	0	0	47	23	5	0				.333	.404	.548	.952
11	Senators	13	4/21/1908	WSH	@	NYH	L 13-16	40	11	5	0	0	9	8	1	2	3		49	16	5	0				.275	.408	.400	.808
12	Twins	12	7/23/2019	MIN	vs	NYY	L 12-14	44	15	3	0	4	12	8	2	8	0	0	55	30	7	0	1	0	1	.341	.455	.682	1.136
13	Twins	12	5/17/2002	MIN	@	NYY	L 12-13	59	20	3	0	0	12	4	0	13	1	0	65	23	3	1	1	1	0	.339	.375	.390	.765
14	Twins	12	7/31/1991	MIN	@	NYY	W 12-3	46	20	0	0	4	12	1	0	6	0	0	47	32	4	0	0	0	2	.435	.447	.696	1.142
15	Twins	12	4/5/1989	MIN	vs	NYY	W 12-2	41	17	4	1	2	11	3	0	4	0	1	44	29	7	0	0	1	0	.415	.455	.707	1.162
16	Twins	12	8/13/1988	MIN	vs	NYY	W 12-2	37	18	3	0	2	12	5	0	3	0	1	46	27	5	1	3	0	1	.486	.511	.730	1.241
17	Senators	12	8/12/1960	WSH	@	NYY	W 12-7	37	13	0	1	3	11	11	0	8	1	0	50	24	4	2	0	1	2	.351	.500	.649	1.149
18	Senators	12	5/22/1953	WSH	vs	NYY	W 12-4	42	18	2	0	1	11	5	0	2	0	0	48	23	3	1		0	0	.429	.489	.548	1.037
19	Senators	12	8/13/1952	WSH	@	NYY	W 12-4	41	17	1	0	1	12	10	0	4	2	0	52	21	2	1		0	0	.415	.529	.512	1.042
20	Senators	12	6/29/1950	WSH	@	NYY	W 12-7	44	18	2	1	1	12	9	0	2	0	0	54	25	4	1		0	0	.409	.509	.568	1.078
21	Senators	12	5/31/1933	WSH	vs	NYY	W 12-7	37	12	3	1	0	12	4	0	4	0	0	43	17	4	2				.324	.390	.459	.850
22	Senators	12	7/4/1932	WSH	vs	NYY	W 12-6	40	16	2	0	2	11	4	1	5	1	0	45	24	4	0				.400	.467	.600	1.067
23	Senators	12	5/19/1932	WSH	@	NYY	W 12-7	37	12	3	0	1	12	10	0	6	1	1	49	18	4	2				.324	.468	.486	.955
24	Senators	12	8/30/1930	WSH	vs	NYY	W 12-6	37	15	1	3	0	11	6	0	3	1	0	44	22	4	1				.405	.488	.595	1.083
25	Senators	12	8/30/1926	WSH	@	NYY	W 12-6	39	12	2	1	1	9	5	1	5	1	2	45	19	4	0				.308	.400	.487	.887