12 players are tied for the most homers for the Twins in a game, with 3 homers. The first three are Miguel Sanó on May 18, 2021, Nelson Cruz on August 3, 2019 and on July 25, 2019 and Max Kepler on June 6, 2019 and on August 1, 2016.

Interpreted as:

twins player with most hr in a regular-season game

	NAME	HR	DATE	TM		OPP	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Miguel Sanó M. Sanó	3	5/18/2021	MIN	vs	CWS	4	3	3	0	0	4	0	0	0	0	0	4	12	3	0	0	0	0
2	Nelson Cruz N. Cruz	3	8/3/2019	MIN	vs	KCR	4	3	3	0	0	5	0	0	1	0	0	4	12	3	0	0	0	0
3	Nelson Cruz N. Cruz	3	7/25/2019	MIN	@	CWS	5	3	3	0	0	5	0	0	1	0	0	5	12	3	0	0	0	0
4	Max Kepler M. Kepler	3	6/6/2019	MIN	@	CLE	4	3	4	0	0	4	1	0	0	0	0	5	13	3	0	0	0	0
5	Eddie Rosario E. Rosario	3	6/3/2018	MIN	vs	CLE	5	3	3	0	0	4	0	0	0	0	0	5	12	3	0	0	0	0
6	Byron Buxton B. Buxton	3	8/27/2017	MIN	@	TOR	5	4	4	0	0	5	0	0	0	1	0	5	13	3	0	0	0	0
7	Eddie Rosario E. Rosario	3	6/13/2017	MIN	vs	SEA	5	3	4	0	0	5	0	0	0	0	0	5	13	3	0	0	0	0
8	Brian Dozier B. Dozier	3	9/5/2016	MIN	vs	KCR	5	3	3	0	0	4	0	0	2	0	0	5	12	3	0	0	0	0
9	Max Kepler M. Kepler	3	8/1/2016	MIN	@	CLE	6	3	4	0	0	6	0	0	0	0	0	6	13	3	0	0	0	0
10	Justin Morneau J. Morneau	3	7/6/2007	MIN	@	CWS	5	3	3	0	0	6	0	0	0	0	0	5	12	3	0	0	0	0
11	Tony Oliva T. Oliva	3	7/3/1973	MIN	@	KCR	5	3	3	0	0	3	0	0	0	0	0	5	12	3	0	0	0	0
12	Harmon Killebrew H. Killebrew	3	9/21/1963	MIN	@	BOS	5	3	3	0	0	5	0	0	1	0	0	5	12	3	0	0	0	0
13	Bob Allison B. Allison	3	5/17/1963	MIN	@	CLE	5	3	3	0	0	6	0	0	1	0	0	5	12	3	0	0	0	0
14	Jim Lemon J. Lemon	3	8/31/1956	WSH	vs	NYY	4	3	3	0	0	4	0	0	1	0	0	4	12	3	0	0	0	0
15	Goose Goslin G. Goslin	3	6/19/1925	WSH	@	CLE	5	3	3	0	0	4	1	0	1	0	0	6	12	3	0
16	Byron Buxton B. Buxton	2	6/22/2025	MIN	vs	MIL	5	2	3	0	0	2	1	0	1	1	0	6	9	2	0	0	1	0
17	Byron Buxton B. Buxton	2	6/19/2025	MIN	@	CIN	6	2	3	1	0	2	0	0	1	0	0	6	10	3	0	0	0	0
18	Willi Castro W. Castro	2	6/3/2025	MIN	@	ATH	4	2	2	0	0	2	1	0	2	0	0	5	8	2	0	0	0	0
19	Willi Castro W. Castro	2	5/30/2025	MIN	@	SEA	3	3	2	0	0	3	2	0	0	0	0	5	8	2	0	0	0	0
20	Trevor Larnach T. Larnach	2	8/24/2024	MIN	vs	STL	4	2	3	0	0	4	0	0	1	0	0	4	9	2	0	0	0	0
21	Byron Buxton B. Buxton	2	8/11/2024	MIN	vs	CLE	4	2	2	0	0	3	0	0	1	0	0	4	8	2	0	0	0	0
22	Byron Buxton B. Buxton	2	7/21/2024	MIN	vs	MIL	5	2	2	0	0	2	0	0	0	0	0	5	8	2	0	0	0	0
23	Carlos Correa C. Correa	2	6/16/2024	MIN	vs	OAK	5	2	3	0	0	3	0	0	1	0	0	5	9	2	0	0	0	0
24	Ryan Jeffers R. Jeffers	2	5/30/2024	MIN	vs	KCR	3	2	2	0	0	3	1	0	0	0	0	4	8	2	0	0	0	0
25	Byron Buxton B. Buxton	2	5/21/2024	MIN	@	WSH	5	2	2	0	0	3	0	0	1	0	0	5	8	2	0	0	0	1