Carl Mays and Urban Shocker were tied for winning the most games in 1921, with 27 wins.

	NAME	W	SEASON	TM	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Carl Mays C. Mays	27	1921	NYY	9	.750	49	38	3.05	70	30	1	7	336.2	332	114	145	11	76	9	10	1,400	2	1.87	2.03	0.92	0.29	5.0	5.4	1.21	.260	3.88	71	3.87	93	8.88	11.3
2	Urban Shocker U. Shocker	27	1921	SLA	12	.692	47	38	3.55	132	30	4	4	326.2	345	129	151	21	86	6	8	1,401	3	3.64	2.37	1.53	0.58	9.4	6.1	1.32	.280	4.16	81	3.98	93	9.51	12.2
3	Red Faber R. Faber	25	1921	CWS	15	.625	43	39	2.48	124	32	4	1	330.2	293	91	107	10	87	7	4	1,350	5	3.38	2.37	1.43	0.27	9.2	6.4	1.15	.252	2.91	58	3.60	87	7.97	19.3
4	Stan Coveleski S. Coveleski	23	1921	CLE	13	.639	43	40	3.37	99	28	2	2	315.0	341	118	137	6	84	4	3	1,358	5	2.83	2.40	1.18	0.17	7.3	6.2	1.35	.288	3.91	78	3.56	85	9.74	22.9
5	Sad Sam Jones S. Sam Jones	23	1921	BSA	16	.590	40	38	3.22	98	25	5	1	298.2	318	107	122	1	78	6	2	1,257	1	2.95	2.35	1.26	0.03	7.8	6.2	1.33	.295	3.68	78	3.33	82	9.58	23.5
6	Wilbur Cooper W. Cooper	22	1921	PIT	14	.611	38	38	3.25	134	29	2	0	327.0	341	118	145	9	80	10	0	1,377	4	3.69	2.20	1.68	0.25	9.7	5.8	1.29	.290	3.99	86	3.47	89	9.39	15.4
7	Burleigh Grimes B. Grimes	22	1921	BKN	13	.629	37	35	2.83	136	30	2	0	302.1	313	95	120	6	76	5	1	1,253	6	4.05	2.26	1.79	0.18	10.9	6.1	1.29	.298	3.57	76	3.27	85	9.32	19.7
8	Art Nehf A. Nehf	20	1921	NYG	10	.667	41	34	3.63	67	18	2	1	260.2	266	105	116	18	55	2	5	1,067	5	2.31	1.90	1.22	0.62	6.3	5.2	1.23	.268	4.01	97	4.14	108	9.18	-8.7
9	Joe Oeschger J. Oeschger	20	1921	BSN	14	.588	46	36	3.52	68	19	3	0	299.0	303	117	128	11	97	15	10	1,248	5	2.05	2.92	0.70	0.33	5.4	7.8	1.34	.276	3.85	96	4.25	113	9.12	-17.1
10	Waite Hoyt W. Hoyt	19	1921	NYY	13	.594	43	32	3.09	102	21	1	3	282.1	301	97	121	3	81	5	7	1,201	3	3.25	2.58	1.26	0.10	8.5	6.7	1.35	.295	3.86	72	3.43	82	9.60	23.1
11	Dickey Kerr D. Kerr	19	1921	CWS	17	.528	44	37	4.72	80	25	3	1	308.2	357	162	182	12	96	11	5	1,360	5	2.33	2.80	0.83	0.35	5.9	7.1	1.47	.297	5.31	111	4.13	100	10.41	-0.3
12	Eppa Rixey E. Rixey	19	1921	CIN	18	.514	40	37	2.78	76	21	2	1	301.0	324	93	128	1	66	5	3	1,260	6	2.27	1.97	1.15	0.03	6.0	5.2	1.30	.290	3.83	77	3.35	90	9.69	12.3
13	Jesse Haines J. Haines	18	1921	SLN	12	.600	37	29	3.50	84	14	2	0	244.1	261	95	112	15	56	8	5	1,013	2	3.09	2.06	1.50	0.55	8.3	5.5	1.30	.289	4.13	94	4.00	105	9.61	-5.6
14	George Mogridge G. Mogridge	18	1921	WSH	14	.563	38	36	3.00	101	21	4	0	288.0	301	96	119	12	66	7	2	1,217	3	3.16	2.06	1.53	0.38	8.3	5.4	1.27	.280	3.72	73	3.70	93	9.41	8.9
15	Bob Shawkey B. Shawkey	18	1921	NYY	12	.600	38	31	4.08	126	18	3	2	245.0	245	111	131	15	86	7	6	1,053	2	4.63	3.16	1.47	0.55	12.0	8.2	1.35	.281	4.81	95	4.01	96	9.00	4.4
16	Fred Toney F. Toney	18	1921	NYG	11	.621	42	32	3.61	63	16	1	3	249.1	274	100	112	14	65	4	9	1,054	4	2.27	2.35	0.97	0.51	6.0	6.2	1.36	.286	4.04	96	4.16	108	9.89	-8.8
17	Tom Zachary T. Zachary	18	1921	WSH	16	.529	39	30	3.96	53	16	2	1	250.0	314	110	130	10	59	6	8	1,084	1	1.91	2.12	0.90	0.36	4.9	5.4	1.49	.318	4.68	96	3.98	99	11.30	-0.3
18	Walter Johnson W. Johnson	17	1921	WSH	14	.548	35	32	3.51	143	25	1	1	264.0	265	103	122	7	92	2	2	1,119	7	4.88	3.14	1.55	0.24	12.8	8.2	1.35	.295	4.16	85	3.43	86	9.03	16.4
19	Dolf Luque D. Luque	17	1921	CIN	19	.472	41	36	3.38	102	25	3	3	304.0	318	114	132	13	64	1	5	1,259	2	3.02	1.89	1.59	0.38	8.1	5.1	1.26	.283	3.91	93	3.63	97	9.41	2.6
20	Rube Marquard R. Marquard	17	1921	CIN	14	.548	39	36	3.39	88	18	2	0	265.2	291	100	123	8	50	7	1	1,116	5	2.98	1.69	1.76	0.27	7.9	4.5	1.28	.294	4.17	93	3.48	93	9.86	7
21	Bullet Joe Bush B. Joe Bush	16	1921	BSA	9	.640	37	32	3.50	96	21	3	2	254.1	244	99	111	10	93	6	4	1,066	7	3.40	3.29	1.03	0.35	9.0	8.7	1.33	.272	3.93	84	4.03	100	8.63	-0.2
22	Dixie Davis D. Davis	16	1921	SLA	16	.500	40	36	4.44	100	20	2	0	265.1	279	131	150	12	123	10	1	1,158	6	3.39	4.17	0.81	0.41	8.6	10.6	1.52	.292	5.09	101	4.44	103	9.46	-3.4
23	Eddie Rommel E. Rommel	16	1921	PHA	23	.410	46	32	3.94	71	20	0	3	285.1	312	125	155	21	87	1	14	1,230	4	2.24	2.74	0.82	0.66	5.8	7.1	1.40	.277	4.89	89	4.49	104	9.84	-5.1
24	George Uhle G. Uhle	16	1921	CLE	13	.552	41	28	4.01	63	13	2	2	238.0	288	106	132	9	63	4	9	1,040	3	2.38	2.38	1.00	0.34	6.1	6.1	1.47	.310	4.99	93	3.91	93	10.89	8.1
25	Grover Alexander G. Alexander	15	1921	CHC	13	.536	31	30	3.39	77	20	3	1	252.0	286	95	110	10	33	1	1	1,033	1	2.75	1.18	2.33	0.36	7.5	3.2	1.27	.303	3.93	90	3.41	88	10.21	13.4