| NAME | W | L | W% | G | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | B. Colon | 229 | 172 | .571 | 515 | 504 | 4.10 | 2,311 | 31 | 11 | 0 | 3163.2 | 3,281 | 1,441 | 1,562 | 412 | 824 | 58 | 2 | 41 | 13,345 | 36 | 6.57 | 2.34 | 2.80 | 1.17 | 17.3 | 6.2 | 1.30 | .295 | 4.44 | 95 | 4.15 | 96 | 9.33 | 57.3 | |
| 2 | R. Halladay | 202 | 105 | .658 | 414 | 388 | 3.39 | 2,104 | 66 | 20 | 1 | 2735.1 | 2,637 | 1,031 | 1,131 | 234 | 590 | 81 | 6 | 28 | 11,234 | 56 | 6.92 | 1.94 | 3.57 | 0.77 | 18.7 | 5.3 | 1.18 | .292 | 3.72 | 77 | 3.38 | 77 | 8.68 | 294.5 | |
| 3 | T. Hudson | 222 | 133 | .625 | 482 | 479 | 3.49 | 2,080 | 26 | 13 | 0 | 3126.2 | 2,957 | 1,213 | 1,319 | 248 | 917 | 124 | 0 | 84 | 13,005 | 84 | 5.99 | 2.64 | 2.27 | 0.71 | 16.0 | 7.1 | 1.24 | .281 | 3.80 | 83 | 3.78 | 90 | 8.51 | 152.3 | |
| 4 | M. Buehrle | 214 | 160 | .572 | 518 | 493 | 3.81 | 1,870 | 33 | 10 | 0 | 3283.1 | 3,472 | 1,391 | 1,542 | 361 | 734 | 79 | 6 | 49 | 13,705 | 27 | 5.13 | 2.01 | 2.55 | 0.99 | 13.6 | 5.4 | 1.28 | .292 | 4.23 | 87 | 4.11 | 93 | 9.52 | 111.9 | |
| 5 | CC Sabathia | 251 | 161 | .609 | 561 | 560 | 3.74 | 3,093 | 38 | 12 | 0 | 3577.1 | 3,404 | 1,485 | 1,623 | 382 | 1,099 | 123 | 0 | 44 | 14,989 | 74 | 7.78 | 2.76 | 2.81 | 0.96 | 20.6 | 7.3 | 1.26 | .294 | 4.08 | 87 | 3.77 | 87 | 8.56 | 223.7 | |
| 6 | Z. Greinke | 225 | 156 | .591 | 586 | 541 | 3.49 | 2,979 | 17 | 5 | 1 | 3389.1 | 3,207 | 1,315 | 1,410 | 367 | 762 | 79 | 8 | 25 | 13,877 | 101 | 7.91 | 2.02 | 3.91 | 0.97 | 21.5 | 5.5 | 1.17 | .293 | 3.74 | 83 | 3.51 | 85 | 8.52 | 235 | |
| 7 | J. Verlander | 266 | 158 | .627 | 555 | 555 | 3.32 | 3,553 | 26 | 9 | 0 | 3567.2 | 3,046 | 1,317 | 1,428 | 371 | 1,004 | 121 | 0 | 28 | 14,607 | 99 | 8.96 | 2.53 | 3.54 | 0.94 | 24.3 | 6.9 | 1.14 | .280 | 3.60 | 79 | 3.43 | 81 | 7.68 | 310.9 | |
| 8 | A. Wainwright | 200 | 128 | .610 | 478 | 411 | 3.53 | 2,202 | 28 | 11 | 3 | 2668.1 | 2,577 | 1,047 | 1,117 | 233 | 736 | 81 | 13 | 40 | 11,116 | 51 | 7.43 | 2.48 | 2.99 | 0.79 | 19.8 | 6.6 | 1.24 | .298 | 3.77 | 88 | 3.53 | 87 | 8.69 | 152.8 | |
| 9 | J. Lester | 200 | 117 | .631 | 452 | 451 | 3.66 | 2,488 | 15 | 4 | 0 | 2740.0 | 2,610 | 1,114 | 1,215 | 294 | 892 | 90 | 0 | 13 | 11,487 | 63 | 8.17 | 2.93 | 2.79 | 0.97 | 21.7 | 7.8 | 1.28 | .300 | 3.99 | 86 | 3.77 | 92 | 8.57 | 101.7 | |
| 10 | C. Kershaw | 223 | 96 | .699 | 455 | 451 | 2.53 | 3,052 | 25 | 15 | 0 | 2855.1 | 2,193 | 804 | 881 | 235 | 713 | 46 | 1 | 28 | 11,279 | 108 | 9.62 | 2.25 | 4.28 | 0.74 | 27.1 | 6.3 | 1.02 | .271 | 2.78 | 65 | 2.85 | 70 | 6.91 | 375.1 | |
| 11 | M. Scherzer | 220 | 117 | .653 | 483 | 474 | 3.22 | 3,489 | 12 | 5 | 0 | 2963.0 | 2,433 | 1,059 | 1,132 | 354 | 779 | 114 | 2 | 20 | 11,987 | 80 | 10.60 | 2.37 | 4.48 | 1.08 | 29.1 | 6.5 | 1.08 | .287 | 3.44 | 77 | 3.23 | 78 | 7.39 | 302.5 |