The Oakland Athletics had their best record against the run line in 2021 on Fridays, with a run-line record of 16-11.

which day of the week do the athletics peform the best against the spread
Interpreted as:
Which day of the week do the athletics peform the best against the spread this season?
FridayAthleticsWednesdayAthleticsThursdayAthleticsSaturdayAthleticsSundayAthleticsTuesdayAthleticsMondayAthletics16-1113-912-915-1213-1312-144-9
TEAMWEEKDAYGATSATS COV %ATS AVGO/U RECO/U AVGW%WLABRH2B3BHRRBISHSFSBCSBBIBBHBPSOGIDPPATBXBHAVGOBPSLGOPS
Oakland AthleticsOakland AthleticsFriday2716-1159.3+0.710-16-1-0.1.66718990713322040336127266798119245151,03237479.243.327.412.740
Oakland AthleticsOakland AthleticsWednesday2213-959.1+0.18-13-1+0.7.591139736108180313259739124631111781182229259.245.310.397.707
Oakland AthleticsOakland AthleticsThursday2112-957.1-0.19-10-2+0.4.571129696981604012191171331000151691581926562.230.336.381.717
Oakland AthleticsOakland AthleticsSaturday2715-1255.6+0.517-10+0.7.5191413931141235475431335816188517218181,04942195.252.326.452.778
Oakland AthleticsOakland AthleticsSunday2613-1350-110-16-1.2.423111585491187295318645173745132141295031965.219.290.374.663
Oakland AthleticsOakland AthleticsTuesday2612-1446.2-0.713-12-1+0.8.500131384912020756229115111171804112071895235487.244.313.417.730
Oakland AthleticsOakland AthleticsMonday134-930.8-27-6+1.38558422529428014491371421121181048016442.223.309.389.698
StatMuse has team, game-level data for run-line records going back to the 2016 season.
Some of the information used here was obtained free of charge from Retrosheet.