The St. Louis Maroons have the highest run differential by a team in a season, with a differential of 458 runs in 1884.

which mlb team had the best run differential season

TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	SH	SF	SB	CS	BB	IBB	HBP	SO	GIDP	PA	TB	XBH	AVG	OBP	SLG	OPS
St. Louis Maroons	458	1884	114	.832	94	19	4,285	887	1,251	259	41	32						181			542		4,466	1,688	332	.292		.394
New York Yankees	411	1939	152	.702	106	45	5,300	967	1,521	259	55	166	904	92		72	37	701		36	543	99	6,129	2,388	480	.287	.374	.451	.825
New York Yankees	371	1927	155	.714	110	44	5,354	976	1,644	291	103	158	907	204		90	64	642		22	610		6,222	2,615	552	.307	.384	.488	.872
St. Louis Browns	370	1887	138	.704	95	40	5,048	1,131	1,550	261	78	39	862			581		442		67	342		5,557	2,084	378	.307	.371	.413	.783
Chicago White Stockings	367	1876	66	.788	52	14	2,748	624	926	131	32	8	441					70			45		2,818	1,145	171	.337		.417
Chicago White Stockings	364	1885	113	.777	87	25	4,093	834	1,079	184	75	54	606					340			429		4,433	1,575	313	.264		.385
Baltimore Orioles	363	1895	132	.669	87	43	4,725	1,009	1,530	235	89	25	828	125		310		355		106	243		5,311	2,018	349	.324	.384	.427	.811
Boston Beaneaters	360	1897	135	.705	93	39	4,937	1,025	1,574	230	83	45	885	114		233		423		47	263		5,521	2,105	358	.319	.378	.426	.804
Boston Reds	353	1891	139	.689	93	42	4,889	1,028	1,341	163	100	52	776			447		651		66	499		5,606	1,860	315	.274	.367	.380	.748
Baltimore Orioles	352	1894	129	.695	89	39	4,799	1,171	1,647	271	150	33	976	151		324		516		98	200		5,564	2,317	454	.343	.418	.483	.901
St. Louis Browns	352	1886	139	.669	93	46	5,009	944	1,365	206	85	20	655			336		400		52	425		5,461	1,801	311	.273	.333	.360	.692
Chicago White Stockings	345	1886	126	.726	90	34	4,378	900	1,223	198	87	53	673			213		460			513		4,838	1,754	338	.279		.401
Los Angeles Dodgers	334	2022	162	.685	111	51	5,526	847	1,418	325	31	212	812	3	53	98	18	607	22	56	1,374	85	6,245	2,441	568	.257	.333	.442	.775
New York Yankees	334	1936	155	.667	102	51	5,591	1,065	1,676	315	83	182	997	67		77	40	700		33	593		6,391	2,703	580	.300	.381	.483	.864
Pittsburgh Pirates	334	1902	142	.741	103	36	4,926	774	1,410	189	95	18	660	118		222		372		64	440		5,480	1,843	302	.286	.344	.374	.718
Baltimore Orioles	333	1896	132	.698	90	39	4,719	995	1,548	207	100	23	854	98		441		386		120	201		5,323	2,024	330	.328	.393	.429	.822
Chicago Cubs	323	1906	155	.763	116	36	5,018	704	1,316	181	71	20	539	231		283		448		45	516		5,742	1,699	272	.262	.328	.339	.667
New York Gothams	321	1885	112	.759	85	27	4,029	691	1,085	150	82	16	464					221			312		4,250	1,447	248	.269		.359
New York Metropolitans	311	1884	112	.701	75	32	4,012	734	1,052	155	64	22						203		35	315		4,250	1,401	241	.262	.304	.349	.653
Baltimore Orioles	310	1898	154	.644	96	53	5,242	933	1,584	154	77	12	757	79		250		519		160	316		6,000	1,928	243	.302	.382	.368	.750
New York Yankees	309	1998	162	.704	114	48	5,643	965	1,625	290	31	207	907	32	59	153	63	653	34	57	1,025	145	6,444	2,598	528	.288	.364	.460	.825
New York Yankees	308	1937	157	.662	102	52	5,487	979	1,554	282	73	174	921	61		60	36	712		34	607		6,294	2,504	529	.283	.369	.456	.825
New York Yankees	307	1931	155	.614	94	59	5,608	1,067	1,667	276	78	155	990	87		139	68	750		28	554		6,473	2,564	509	.297	.383	.457	.840
Seattle Mariners	300	2001	162	.716	116	46	5,680	927	1,637	310	38	169	881	48	70	174	42	614	54	62	989	112	6,474	2,530	517	.288	.360	.445	.805
New York Yankees	294	1942	154	.669	103	51	5,305	801	1,429	223	57	108	744	84		69	33	591		29	556	103	6,009	2,090	388	.269	.346	.394	.740

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MLB 2023 Division Standings

	NL East	W	L	PCT	GB
1	Braves	104	58	.642
2	Phillies	90	72	.556	14.0
	AL East	W	L	PCT	GB
1	Orioles	101	61	.623
2	Rays	99	63	.611	2.0
	NL West	W	L	PCT	GB
1	Dodgers	100	62	.617
2	Diamondbacks	84	78	.519	16.0
	NL Central	W	L	PCT	GB
1	Brewers	92	70	.568
2	Cubs	83	79	.512	9.0
	AL West	W	L	PCT	GB
1	Astros	90	72	.556
2	Rangers	90	72	.556
	AL Central	W	L	PCT	GB
1	Twins	87	75	.537
2	Tigers	78	84	.481	9.0