The Milwaukee Brewers have the highest run differential by a team in losses in a season, with a differential of -8 runs in 1884.
| TEAM | DIFF | W | SEASON | L | W% | G | AB | R | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brewers | -8 | 0 | 1884 | 4 | .000 | 4 | 13 | |||||||||||||||||||||||
| 2 |  | White Stockings | -29 | 0 | 1876 | 14 | .000 | 14 | 55 | ||||||||||||||||||||||
| 3 |  | Mets | -32 | 0 | 2025 | 16 | .000 | 16 | 516 | 42 | 104 | 15 | 1 | 10 | 41 | 64 | 9 | 121 | 10 | 0 | 594 | 151 | 26 | 0 | 5 | 1 | 14 | .202 | .298 | .293 | .591 |
| 4 | Saints | -38 | 0 | 1884 | 6 | .000 | 7 | 14 | |||||||||||||||||||||||
| 5 |  | Dodgers | -39 | 0 | 2020 | 17 | .000 | 17 | 569 | 57 | 124 | 27 | 2 | 22 | 54 | 56 | 9 | 151 | 4 | 4 | 636 | 221 | 51 | 1 | 1 | 2 | 9 | .218 | .298 | .388 | .686 |
| 6 |  | Yankees | -40 | 0 | 2025 | 18 | .000 | 18 | 597 | 60 | 126 | 20 | 3 | 18 | 55 | 61 | 7 | 179 | 13 | 4 | 671 | 206 | 41 | 0 | 6 | 3 | 12 | .211 | .289 | .345 | .634 |
| 7 |  | Giants | -44 | 0 | 2025 | 19 | .000 | 19 | 621 | 49 | 126 | 22 | 0 | 14 | 49 | 45 | 7 | 171 | 9 | 4 | 678 | 190 | 36 | 1 | 4 | 0 | 14 | .203 | .263 | .306 | .569 |
| 8 |  | Tigers | -46 | 0 | 2025 | 15 | .000 | 15 | 495 | 37 | 95 | 12 | 5 | 14 | 35 | 45 | 2 | 157 | 6 | 0 | 546 | 159 | 31 | 1 | 3 | 2 | 8 | .192 | .261 | .321 | .582 |
| 9 | | White Stockings | -50 | 0 | 1880 | 17 | .000 | 19 | 68 | ||||||||||||||||||||||
| 10 | | Dodgers | -51 | 0 | 2025 | 15 | .000 | 15 | 509 | 47 | 114 | 27 | 1 | 16 | 47 | 38 | 1 | 146 | 7 | 4 | 552 | 191 | 44 | 1 | 3 | 2 | 10 | .224 | .278 | .375 | .653 |
| 11 |  | Padres | -52 | 0 | 2025 | 15 | .000 | 15 | 491 | 34 | 103 | 16 | 2 | 8 | 30 | 31 | 5 | 108 | 4 | 3 | 535 | 147 | 26 | 3 | 5 | 1 | 12 | .210 | .261 | .299 | .561 |
| 12 |  | Brewers | -53 | 0 | 1891 | 15 | .000 | 15 | 49 | ||||||||||||||||||||||
| 13 |  | Astros | -55 | 0 | 2025 | 21 | .000 | 21 | 690 | 53 | 143 | 24 | 1 | 11 | 49 | 62 | 5 | 178 | 7 | 2 | 764 | 202 | 36 | 3 | 4 | 1 | 12 | .207 | .276 | .293 | .569 |
| 14 |  | Braves | -57 | 0 | 2025 | 22 | .000 | 22 | 718 | 52 | 138 | 24 | 4 | 16 | 49 | 73 | 5 | 212 | 12 | 3 | 799 | 218 | 44 | 0 | 3 | 0 | 9 | .192 | .270 | .304 | .574 |
| 15 |  | Rays | -57 | 0 | 2020 | 20 | .000 | 20 | 655 | 55 | 122 | 35 | 1 | 19 | 51 | 74 | 10 | 224 | 9 | 4 | 740 | 216 | 55 | 0 | 1 | 2 | 12 | .186 | .278 | .330 | .608 |
| 16 |  | Twins | -59 | 0 | 2025 | 20 | .000 | 20 | 651 | 43 | 129 | 30 | 3 | 10 | 41 | 50 | 8 | 175 | 10 | 3 | 714 | 195 | 43 | 0 | 5 | 0 | 11 | .198 | .262 | .300 | .561 |
| 17 |  | Phillies | -62 | 0 | 2025 | 18 | .000 | 18 | 623 | 50 | 138 | 19 | 2 | 11 | 50 | 66 | 6 | 168 | 12 | 2 | 696 | 194 | 32 | 0 | 1 | 3 | 11 | .222 | .302 | .311 | .613 |
| 18 |  | Orioles | -62 | 0 | 1890 | 19 | .000 | 23 | 77 | ||||||||||||||||||||||
| 19 | | Red Caps | -64 | 0 | 1878 | 19 | .000 | 19 | 55 | ||||||||||||||||||||||
| 20 |  | Mariners | -65 | 0 | 2025 | 19 | .000 | 19 | 631 | 57 | 124 | 18 | 1 | 19 | 53 | 73 | 13 | 176 | 22 | 6 | 722 | 201 | 38 | 2 | 3 | 2 | 11 | .197 | .292 | .319 | .610 |
| 21 | | Red Caps | -65 | 0 | 1877 | 18 | .000 | 19 | 67 | ||||||||||||||||||||||
| 22 |  | Cardinals | -66 | 0 | 2025 | 20 | .000 | 20 | 696 | 60 | 160 | 33 | 0 | 10 | 55 | 63 | 5 | 170 | 13 | 3 | 768 | 223 | 43 | 2 | 2 | 4 | 23 | .230 | .298 | .320 | .618 |
| 23 | | Padres | -66 | 0 | 2020 | 23 | .000 | 23 | 744 | 67 | 163 | 38 | 5 | 20 | 65 | 80 | 7 | 201 | 15 | 3 | 836 | 271 | 63 | 2 | 3 | 2 | 18 | .219 | .300 | .364 | .664 |
| 24 | | Rays | -67 | 0 | 2025 | 23 | .000 | 23 | 742 | 44 | 159 | 26 | 2 | 12 | 42 | 63 | 5 | 189 | 17 | 8 | 817 | 225 | 40 | 0 | 7 | 0 | 22 | .214 | .278 | .303 | .581 |
| 25 | | Twins | -67 | 0 | 2020 | 24 | .000 | 24 | 768 | 68 | 157 | 22 | 0 | 26 | 64 | 71 | 8 | 233 | 4 | 3 | 851 | 257 | 48 | 0 | 4 | 3 | 15 | .204 | .277 | .335 | .612 |
Some of the information used here was obtained free of charge from Retrosheet.
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