Between the 1980 and 1989 seasons, Nolan Ryan had the lowest ERA when pitching at least 2050 innings, with an ERA of 3.14.
| NAME | ERA | IP | G | W | L | W% | GS | SO | CG | SHO | SV | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 3.14 | 2094.0 | 314 | 122 | 104 | .540 | 314 | 2,167 | 44 | 15 | 0 | 1,603 | 730 | 835 | 128 | 894 | 53 | 0 | 34 | 8,704 | 123 | 9.31 | 3.84 | 2.42 | 0.55 | 24.9 | 10.3 | 1.19 | .270 | 3.59 | 90 | 2.82 | 81 | 6.89 | 159.5 |
| 2 |  | F. Valenzuela | 3.19 | 2144.2 | 298 | 128 | 103 | .554 | 287 | 1,644 | 102 | 27 | 2 | 1,876 | 760 | 869 | 133 | 838 | 16 | 5 | 54 | 8,957 | 81 | 6.90 | 3.52 | 1.96 | 0.56 | 18.4 | 9.4 | 1.27 | .276 | 3.65 | 91 | 3.21 | 90 | 7.87 | 84 |
| 3 | | B. Welch | 3.21 | 2082.1 | 313 | 137 | 93 | .596 | 311 | 1,457 | 47 | 22 | 0 | 1,885 | 743 | 821 | 155 | 666 | 49 | 0 | 40 | 8,655 | 43 | 6.30 | 2.88 | 2.19 | 0.67 | 16.8 | 7.7 | 1.23 | .273 | 3.55 | 90 | 3.34 | 92 | 8.15 | 63.4 |
| 4 | | D. Stieb | 3.32 | 2328.2 | 339 | 140 | 109 | .562 | 331 | 1,380 | 92 | 27 | 1 | 2,019 | 859 | 954 | 183 | 825 | 104 | 4 | 29 | 9,654 | 39 | 5.33 | 3.19 | 1.67 | 0.71 | 14.3 | 8.5 | 1.22 | .256 | 3.69 | 80 | 3.77 | 93 | 7.80 | 77.5 |
| 5 | | B. Blyleven | 3.64 | 2078.1 | 291 | 123 | 103 | .544 | 288 | 1,480 | 94 | 21 | 0 | 1,984 | 841 | 919 | 212 | 557 | 73 | 1 | 26 | 8,623 | 44 | 6.41 | 2.41 | 2.66 | 0.92 | 17.2 | 6.5 | 1.22 | .281 | 3.98 | 89 | 3.56 | 88 | 8.59 | 109.6 |
| 6 |  | J. Morris | 3.66 | 2443.2 | 332 | 162 | 119 | .577 | 332 | 1,629 | 133 | 20 | 0 | 2,212 | 995 | 1,085 | 264 | 858 | 23 | 0 | 66 | 10,208 | 124 | 6.00 | 3.16 | 1.90 | 0.97 | 16.0 | 8.4 | 1.26 | .262 | 4.00 | 92 | 3.89 | 94 | 8.15 | 66.7 |
| 7 | | C. Hough | 3.67 | 2121.2 | 331 | 128 | 114 | .529 | 282 | 1,363 | 93 | 11 | 2 | 1,842 | 864 | 999 | 218 | 867 | 80 | 22 | 18 | 8,942 | 98 | 5.78 | 3.68 | 1.57 | 0.92 | 15.2 | 9.7 | 1.28 | .253 | 4.24 | 90 | 4.14 | 103 | 7.81 | -28.2 |
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HR
182
16th
R
686
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3.86
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