Frank Thomas has hit the most career homers for the White Sox, with 448 home runs.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Frank Thomas F. Thomas	448	1,959	6,956	1,327	2,136	447	11	1,465	1,466	71	1,165	32	23	8,602	3,949	906	0	109	162	190	.307	.427	.568	.995	1721	670.2	.424	159	642.9
2	Paul Konerko P. Konerko	432	2,268	8,169	1,141	2,292	406	8	1,383	904	101	1,349	9	3	9,258	4,010	846	1	83	80	271	.281	.356	.491	.847	1402	286	.364	120	226.3
3	José Abreu J. Abreu	243	1,270	4,954	697	1,445	303	16	863	386	117	1,088	11	5	5,506	2,509	562	0	49	56	167	.292	.354	.506	.860	866	217.7	.364	133	211.5
4	Harold Baines H. Baines	221	1,670	6,149	786	1,773	320	44	981	565	11	918	32	21	6,797	2,844	585	8	64	107	172	.288	.346	.463	.809	951	168.9	.352	115	124.5
5	Carlton Fisk C. Fisk	214	1,421	4,896	649	1,259	214	14	762	460	84	798	67	32	5,500	2,143	442	13	47	73	118	.257	.329	.438	.766	703	83	.338	108	51.4
6	Magglio Ordonez M. Ordonez	187	1,001	3,807	624	1,167	240	15	703	333	34	431	82	38	4,212	1,998	442	3	35	20	131	.307	.364	.525	.889	697	169.3	.380	128	149.8
7	Robin Ventura R. Ventura	171	1,254	4,542	658	1,244	219	12	741	668	15	659	15	26	5,310	2,000	402	28	57	86	107	.274	.365	.440	.805	748	115	.353	116	103.6
8	Jermaine Dye J. Dye	164	724	2,669	419	742	150	8	461	251	30	536	23	12	2,970	1,400	322	0	20	14	80	.278	.344	.525	.869	464	102.4	.370	122	80.8
9	Bill Melton B. Melton	154	976	3,497	448	901	134	6	535	418	40	595	20	21	4,011	1,509	294	18	38	27	80	.258	.340	.432	.772	532	102.1	.349	116	72.4
10	Carlos Lee C. Lee	152	880	3,328	533	957	192	10	552	255	26	501	64	26	3,646	1,625	354	3	34	12	78	.288	.340	.488	.828	526	69.6	.355	111	51
11	Ron Kittle R. Kittle	140	657	2,183	292	517	83	3	374	201	28	606	14	15	2,433	1,026	226	0	21	17	46	.237	.307	.470	.777	317	43	.341	109	25.4
12	Jose Valentin J. Valentin	136	672	2,433	403	602	131	17	379	249	15	572	47	20	2,750	1,175	284	37	16	13	38	.247	.319	.483	.802	368	25.6	.342	103	10.7
13	Minnie Minoso M. Minoso	135	1,373	5,011	893	1,523	260	79	808	658	145	427	171	99	5,914	2,346	474	51	49	17	144	.304	.397	.468	.865	971	292.3	.390	136	258.7
14	Jim Thome J. Thome	134	529	1,770	335	469	88	0	369	362	16	544	1	1	2,165	959	222	0	17	35	39	.265	.391	.542	.933	385	119.7	.396	138	103.3
15	Joe Crede J. Crede	125	798	2,768	350	712	143	4	422	170	36	403	4	12	3,010	1,238	272	8	28	5	63	.257	.306	.447	.753	356	-13.2	.324	91	-32.8
16	Sherm Lollar S. Lollar	124	1,358	4,229	485	1,122	186	9	631	525	101	360	17	7	4,922	1,698	319	33	34	49	136	.265	.358	.402	.759	638	75.4	.343	108	49.4
17	A.J. Pierzynski	118	1,068	3,896	452	1,087	198	7	460	179	56	479	7	8	4,177	1,653	323	20	26	40	120	.279	.318	.424	.742	482	-14.8	.321	91	-46.7
18	Greg Walker G. Walker	113	841	2,830	366	741	164	19	442	265	19	511	18	12	3,139	1,282	296	3	22	28	59	.262	.327	.453	.780	416	57.3	.342	109	34.1
19	Alexei Ramirez A. Ramirez	109	1,226	4,656	563	1,272	227	15	542	242	26	587	135	54	4,999	1,856	351	35	40	15	131	.273	.310	.399	.709	536	-31.8	.310	89	-64.6
20	Carlos Quentin C. Quentin	107	478	1,705	269	438	96	3	320	181	78	299	13	6	1,978	861	206	0	14	5	50	.257	.352	.505	.857	309	78	.372	126	61.5
21	Adam Dunn A. Dunn	106	528	1,842	226	371	67	0	278	321	11	720	4	4	2,187	756	173	0	13	15	25	.201	.321	.410	.732	259	16	.323	101	1.6
22	Ray Durham R. Durham	106	1,146	4,479	784	1,246	249	53	484	484	48	758	219	73	5,095	1,919	408	42	42	13	78	.278	.352	.428	.780	684	41.9	.343	104	23.1
23	Tim Anderson T. Anderson	98	895	3,622	528	1,021	179	18	338	143	22	883	117	27	3,808	1,530	295	10	11	4	89	.282	.312	.422	.735	453	-5.9	.315	98	-7.7
24	Pete Ward P. Ward	97	899	2,962	339	753	132	15	407	358	40	517	20	17	3,399	1,206	244	12	27	41	38	.254	.340	.407	.747	427	77.6	.334	117	62.9
25	Ron Karkovice R. Karkovice	96	939	2,597	336	574	120	6	335	233	26	749	24	14	2,948	994	222	65	27	8	39	.221	.289	.383	.672	286	-63.7	.299	81	-71.5