The Chicago White Sox put up their most runs in a game against the Kansas City Athletics on April 23, 1955, with 29 runs.

Interpreted as:

white sox highest scoring regular-season game

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	White Sox	29	4/23/1955	CWS	@	KCA	W 29-6	54	29	5	0	7	28	6	1	4	1	1	63	55	12	0	2	1	0	.537	.571	1.019	1.590
2	White Sox	22	5/31/1970	CWS	@	BOS	W 22-13	51	24	6	1	1	18	3	0	9	1	1	55	35	8	1	0	1	0	.471	.500	.686	1.186
3	White Sox	21	6/26/1960	CWS	vs	BOS	W 21-7	46	22	3	2	3	21	5	1	8	1	0	53	38	8	0	1	0	0	.478	.528	.826	1.354
4	White Sox	21	7/18/1936	CWS	@	PHA	W 21-14	45	20	9	0	1	19	11	1	3	0	0	59	32	10	2				.444	.561	.711	1.273
5	White Sox	20	6/20/2006	CWS	vs	STL	W 20-6	49	24	3	0	4	19	1	2	5	0	0	52	39	7	0	0	0	0	.490	.519	.796	1.315
6	White Sox	20	5/15/1996	CWS	@	MIL	W 20-8	46	21	5	0	2	20	8	1	4	0	0	55	32	7	0	0	3	1	.457	.545	.696	1.241
7	White Sox	20	4/22/1959	CWS	@	KCA	W 20-6	40	16	5	0	1	18	13	1	5	1	0	58	24	6	3	1	1	0	.400	.545	.600	1.145
8	White Sox	20	6/17/1956	CWS	vs	WSH	W 20-2	42	21	4	2	1	18	6	0	2	0	0	51	32	7	0	3	0	1	.500	.529	.762	1.291
9	White Sox	20	4/30/1934	CWS	vs	CLE	W 20-10	42	18	5	1	4	18	6	1	2	1	0	51	37	10	2				.429	.510	.881	1.391
10	White Sox	20	9/9/1921	CWS	vs	DET	W 20-15	43	22	2	4	1	18	3	0	4	1	2	48	35	7	2				.512	.543	.814	1.357
11	White Sox	20	5/11/1911	CWS	vs	WSH	W 20-6	45	21	5	3	1	18	2	2	4	0		51	35	9	2				.467	.510	.778	1.288
12	White Sox	19	7/3/2012	CWS	vs	TEX	W 19-2	44	21	5	1	4	17	4	0	7	0	0	49	40	10	0	1	1	1	.477	.510	.909	1.419
13	White Sox	19	9/27/2003	CWS	@	KCR	W 19-3	48	21	7	0	0	17	5	1	8	1	1	55	28	7	0	1	0	0	.438	.491	.583	1.074
14	White Sox	19	9/2/2001	CWS	vs	CLE	W 19-10	40	17	3	0	3	18	9	1	6	0	0	50	29	6	0	0	0	1	.425	.540	.725	1.265
15	White Sox	19	8/9/2000	CWS	vs	SEA	W 19-3	48	24	5	0	4	19	5	0	4	1	0	53	41	9	0	0	0	1	.500	.547	.854	1.401
16	White Sox	19	8/4/1992	CWS	vs	MIN	W 19-11	40	19	5	0	3	19	7	0	4	3	0	50	33	8	0	3	0	0	.475	.520	.825	1.345
17	White Sox	19	7/20/1940	CWS	@	PHA	W 19-7	43	19	4	0	1	15	7	1	3	0	0	52	26	5	1			2	.442	.529	.605	1.134
18	White Sox	19	7/28/1936	CWS	vs	PHA	W 19-6	44	20	1	1	0	17	9	2	1	0	0	55	23	2	0				.455	.564	.523	1.086
19	White Sox	19	5/11/1936	CWS	@	SLA	W 19-6	46	22	8	0	0	19	12	1	0	0	0	61	30	8	2				.478	.593	.652	1.245
20	White Sox	19	8/31/1926	CWS	@	DET	W 19-2	50	23	5	0	0	19	10	1	3	3	0	61	28	5	0				.460	.557	.560	1.117
21	White Sox	19	8/15/1922	CWS	@	BSA	W 19-11	49	25	3	1	0	18	3	0	4	0	0	56	30	4	4				.510	.538	.612	1.151
22	White Sox	19	5/3/1918	CWS	@	DET	W 19-3	47	25	3	3	0	19	6	0	1	5		56	34	6	3				.532	.585	.723	1.308
23	White Sox	19	5/1/1901	CWS	vs	DET	W 19-9	47	16	2	1	2	14	7	1	1	1	-10	57	26	5	2		-10	-10	.340	.436	.553	.990
24	White Sox	18	4/18/2000	CWS	vs	SEA	W 18-11	40	19	3	0	3	18	8	1	5	1	0	51	31	6	0	2	1	1	.475	.549	.775	1.324
25	White Sox	18	4/23/1981	CWS	vs	BAL	W 18-5	47	26	2	2	1	17	6	0	2	0	0	55	35	5	1	1	0	1	.553	.593	.745	1.337