The 2021 pitchers for the White Sox included Jimmy Cordero, Lucas Giolito, Dylan Cease, Dallas Keuchel and Lance Lynn.
| NO. | NAME | POS | HEIGHT | WEIGHT | DOB | AGE | BIRTHPLACE | ||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 39 |  | A. Bummer | P | 6'3" | 200 | 9/21/1993 | 27 | Valencia, CA |
| 2 | 62 | | Z. Burdi | P | 6'3" | 205 | 3/9/1995 | 26 | Downers Grove, IL |
| 3 | 61 | | R. Burr | P | 6'4" | 225 | 5/28/1994 | 27 | Highlands Ranch, CO |
| 4 | 84 |  | D. Cease | P | 6'2" | 190 | 12/28/1995 | 25 | Milton, GA |
| 5 | 50 | | J. Cordero | P | 6'4" | 222 | 10/19/1991 | 29 | San Cristobal, Dominican Republic |
| 6 | 45 |  | G. Crochet | P | 6'6" | 218 | 6/21/1999 | 22 | Ocean Springs, MS |
| 7 | 63 | | M. Foster | P | 6'0" | 205 | 1/27/1995 | 26 | Valley, AL |
| 8 | 57 | | J. Fry | P | 6'1" | 190 | 7/9/1993 | 27 | Beaverton, OR |
| 9 | 27 | | L. Giolito | P | 6'6" | 245 | 7/14/1994 | 26 | Santa Monica, CA |
| 10 | 31 | | L. Hendriks | P | 6'0" | 225 | 2/10/1989 | 32 | Perth, Australia |
| 11 | 65 | | C. Heuer | P | 6'5" | 195 | 7/3/1996 | 24 | Missoula, MT |
| 12 | 60 |  | D. Keuchel | P | 6'3" | 205 | 1/1/1988 | 33 | Tulsa, OK |
| 13 | 46 |  | C. Kimbrel | P | 6'0" | 210 | 5/28/1988 | 33 | Huntsville, AL |
| 14 | 34 | | M. Kopech | P | 6'3" | 205 | 4/30/1996 | 25 | Mount Pleasant, TX |
| 15 | 58 | | J. Lambert | P | 6'2" | 190 | 11/18/1994 | 26 | Arcadia, CA |
| 16 | 33 | | L. Lynn | P | 6'5" | 280 | 5/12/1987 | 34 | Marion County, IN |
| 17 | 40 | | R. López | P | 6'1" | 200 | 1/4/1994 | 27 | San Pedro de Macoris, Dominican Republic |
| 18 | 43 | | E. Marshall | P | 6'2" | 225 | 4/18/1990 | 31 | Sunnyvale, CA |
| 19 | 64 | | A. McRae | P | 6'2" | 220 | 4/6/1993 | 28 | West Allis, WI |
| 20 | 55 |  | C. Rodón | P | 6'3" | 235 | 12/10/1992 | 28 | Miami, FL |
| 21 | 66 | | J. Ruiz | P | 6'1" | 190 | 10/21/1994 | 26 | Guacara, Venezuela |
| 22 | 53 | | J. Stiever | P | 6'2" | 205 | 5/12/1997 | 24 | Cedarburg, WI |
| 23 | 51 | | R. Tepera | P | 6'1" | 195 | 11/3/1987 | 33 | Lake Jackson, TX |
| 24 | 48 | | M. Wright | P | 6'6" | 215 | 1/3/1990 | 31 | Bennettsville, SC |
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