Paul Konerko has the most career strikeouts for the White Sox, with 1,349 strikeouts.

	NAME	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	wRC	WRAA	wOBA	wRC+	BRAA
1	Paul Konerko P. Konerko	1,349	2,268	8,169	1,141	2,292	406	8	432	1,383	904	101	9	3	9,258	4,010	846	1	83	80	271	.281	.356	.491	.847	1402	286	.364	120	226.3
2	Frank Thomas F. Thomas	1,165	1,959	6,956	1,327	2,136	447	11	448	1,465	1,466	71	32	23	8,602	3,949	906	0	109	162	190	.307	.427	.568	.995	1721	670.2	.424	159	642.9
3	José Abreu J. Abreu	1,088	1,270	4,954	697	1,445	303	16	243	863	386	117	11	5	5,506	2,509	562	0	49	56	167	.292	.354	.506	.860	866	217.6	.364	133	211.5
4	Harold Baines H. Baines	918	1,670	6,149	786	1,773	320	44	221	981	565	11	32	21	6,797	2,844	585	8	64	107	172	.288	.346	.463	.809	951	168.9	.352	115	124.5
5	Yoán Moncada Y. Moncada	906	739	2,779	373	707	156	20	93	338	305	23	32	13	3,122	1,182	269	4	11	6	25	.254	.332	.425	.757	407	30.5	.327	107	28.6
6	Tim Anderson T. Anderson	883	895	3,622	528	1,021	179	18	98	338	143	22	117	27	3,808	1,530	295	10	11	4	89	.282	.312	.422	.735	453	-5.9	.315	98	-7.7
7	Carlton Fisk C. Fisk	798	1,421	4,896	649	1,259	214	14	214	762	460	84	67	32	5,500	2,143	442	13	47	73	118	.257	.329	.438	.766	703	83	.338	108	51.4
8	Ray Durham R. Durham	758	1,146	4,479	784	1,246	249	53	106	484	484	48	219	73	5,095	1,919	408	42	42	13	78	.278	.352	.428	.780	684	41.9	.343	104	23.1
9	Ron Karkovice R. Karkovice	749	939	2,597	336	574	120	6	96	335	233	26	24	14	2,948	994	222	65	27	8	39	.221	.289	.383	.672	286	-63.7	.299	81	-71.5
10	Adam Dunn A. Dunn	720	528	1,842	226	371	67	0	106	278	321	11	4	4	2,187	756	173	0	13	15	25	.201	.321	.410	.732	259	16	.323	101	1.6
11	Robin Ventura R. Ventura	659	1,254	4,542	658	1,244	219	12	171	741	668	15	15	26	5,310	2,000	402	28	57	86	107	.274	.365	.440	.805	748	115	.353	116	103.6
12	Luis Robert Jr. L. Robert Jr.	636	577	2,178	318	565	115	2	102	298	149	25	102	24	2,364	990	219	1	11	12	40	.259	.313	.455	.767	309	27.3	.328	110	27.7
13	Jim Landis J. Landis	608	1,063	3,568	532	892	138	47	83	398	483	53	127	44	4,183	1,373	268	55	24	20	53	.250	.346	.385	.731	515	43	.330	104	22.6
14	Ron Kittle R. Kittle	606	657	2,183	292	517	83	3	140	374	201	28	14	15	2,433	1,026	226	0	21	17	46	.237	.307	.470	.777	317	43	.341	109	25.4
15	Bill Melton B. Melton	595	976	3,497	448	901	134	6	154	535	418	40	20	21	4,011	1,509	294	18	38	27	80	.258	.340	.432	.772	532	102.1	.349	116	72.4
16	Alexei Ramirez A. Ramirez	587	1,226	4,656	563	1,272	227	15	109	542	242	26	135	54	4,999	1,856	351	35	40	15	131	.273	.310	.399	.709	536	-31.8	.310	89	-64.6
17	Jose Valentin J. Valentin	572	672	2,433	403	602	131	17	136	379	249	15	47	20	2,750	1,175	284	37	16	13	38	.247	.319	.483	.802	368	25.6	.342	103	10.7
18	Avisaíl García A. García	551	585	2,173	285	589	85	13	74	289	142	28	26	18	2,358	922	172	0	15	11	55	.271	.322	.424	.746	285	11.8	.322	103	8.2
19	Jim Thome J. Thome	544	529	1,770	335	469	88	0	134	369	362	16	1	1	2,165	959	222	0	17	35	39	.265	.391	.542	.933	385	119.7	.396	138	103.3
20	Jermaine Dye J. Dye	536	724	2,669	419	742	150	8	164	461	251	30	23	12	2,970	1,400	322	0	20	14	80	.278	.344	.525	.869	464	102.4	.370	122	80.8
21	Leury Garcia L. Garcia	534	676	2,165	282	550	85	14	34	200	106	25	63	17	2,345	765	133	33	16	1	36	.254	.295	.353	.648	216	-64.7	.282	75	-67.2
22	Luke Appling L. Appling	528	2,422	8,856	1,319	2,749	440	102	45	1,116	1,302	11	179		10,243	3,528	587	74			129	.310	.399	.398	.798	1538	325.1	.378	115	198.1
23	Gordon Beckham G. Beckham	526	839	2,818	351	681	154	4	67	296	219	44	29	19	3,134	1,044	225	27	26	4	63	.242	.304	.370	.674	310	-44.6	.299	81	-66.2
24	Billy Sullivan B. Sullivan	524	1,052	3,335	317	692	111	33	11	325	160	28	92		3,652	902	155	129				.207	.250	.270	.520	245	-144.2	.254	64	-144.3
25	Yolmer Sanchez Y. Sanchez	519	657	2,239	252	548	113	24	32	215	160	23	30	23	2,459	805	169	24	13	3	38	.245	.300	.360	.660	233	-59.6	.288	79	-62