Dwight Evans has the most career strikeouts for the Red Sox, with 1,643 strikeouts.

	NAME	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Dwight Evans D. Evans	1,643	2,505	8,726	1,435	2,373	474	72	379	1,346	1,337	51	76	56	10,240	4,128	925	51	75	58	220	.272	.369	.473	.842	1593	449.9	.375	129	349
2	Jim Rice J. Rice	1,423	2,089	8,225	1,249	2,452	373	79	382	1,451	670	64	58	34	9,058	4,129	834	5	94	77	315	.298	.352	.502	.854	1410	394.2	.375	128	300.2
3	David Ortiz D. Ortiz	1,411	1,953	7,163	1,204	2,079	524	16	483	1,530	1,133	29	13	7	8,398	4,084	1,023	1	72	196	201	.290	.386	.570	.956	1524	535.9	.400	146	471.1
4	Carl Yastrzemski C. Yastrzemski	1,393	3,308	11,988	1,816	3,419	646	59	452	1,844	1,845	40	168	116	13,991	5,539	1,157	13	105	190	323	.285	.379	.462	.841	2155	643.2	.375	130	469.8
5	Jason Varitek J. Varitek	1,216	1,546	5,099	664	1,307	306	14	193	757	614	61	25	18	5,839	2,220	513	22	43	59	129	.256	.341	.435	.776	752	33.2	.337	99	-5.4
6	Xander Bogaerts X. Bogaerts	987	1,264	4,834	752	1,410	308	15	156	683	461	46	74	17	5,389	2,216	479	5	43	20	114	.292	.356	.458	.814	789	155.1	.350	117	114.5
7	Rafael Devers R. Devers	970	1,053	4,074	663	1,136	273	12	215	696	414	38	33	19	4,549	2,078	500	1	22	65	92	.279	.349	.510	.859	718	171.9	.361	126	142.1
8	Mo Vaughn M. Vaughn	954	1,046	3,828	628	1,165	199	10	230	752	519	71	28	17	4,452	2,074	439	0	34	118	94	.304	.394	.542	.936	800	255.6	.398	136	212.8
9	Rico Petrocelli R. Petrocelli	926	1,553	5,390	653	1,352	237	22	210	773	661	26	10	22	6,170	2,263	469	36	57	61	127	.251	.332	.420	.752	778	131.5	.338	108	57.1
10	Jackie Bradley Jr. J. Bradley Jr.	886	964	3,170	456	749	181	24	101	405	321	54	62	17	3,571	1,281	306	7	19	17	51	.236	.315	.404	.719	409	-12.5	.311	90	-39.4
11	George Scott G. Scott	850	1,192	4,234	527	1,088	158	38	154	562	418	34	27	32	4,740	1,784	350	16	38	56	157	.257	.326	.421	.747	583	77.3	.332	102	15
12	Manny Ramirez M. Ramirez	849	1,083	3,953	743	1,232	256	7	274	868	636	56	7	7	4,682	2,324	537	0	37	128	127	.312	.411	.588	.999	921	346.7	.417	154	318.4
13	Kevin Youkilis K. Youkilis	728	953	3,352	594	961	239	17	133	564	494	86	26	14	3,974	1,633	389	0	42	19	64	.287	.388	.487	.875	655	177.8	.381	130	146.5
14	Ted Williams T. Williams	709	2,292	7,706	1,798	2,654	525	71	521	1,839	2,021	39	24	4	9,791	4,884	1,117	5	20	86	197	.344	.482	.634	1.116	2349	1,219.7	.493	188	1,067
15	Dustin Pedroia D. Pedroia	654	1,512	6,031	922	1,805	394	15	140	725	624	38	138	46	6,777	2,649	549	25	59	25	154	.299	.365	.439	.805	962	175.7	.352	115	120
16	J.D. Martinez	638	637	2,458	399	717	171	8	130	423	270	18	9	1	2,770	1,294	309	0	24	30	82	.292	.363	.526	.889	466	132.9	.373	134	113
17	Trot Nixon T. Nixon	621	982	3,285	547	912	204	28	133	523	454	31	29	13	3,829	1,571	365	17	42	15	56	.278	.366	.478	.845	587	109.9	.365	118	88.2
18	Bobby Doerr B. Doerr	608	1,865	7,093	1,094	2,042	381	89	223	1,247	809	11	54	1	8,028	3,270	693	115			187	.288	.362	.461	.823	1199	272.7	.380	115	143.5
19	Carlton Fisk C. Fisk	588	1,078	3,860	627	1,097	207	33	162	568	389	59	61	26	4,353	1,856	402	13	32	32	86	.284	.356	.481	.837	659	183.6	.374	129	136.8
20	Tony Conigliaro T. Conigliaro	577	802	2,955	441	790	121	23	162	501	264	32	17	20	3,299	1,443	306	18	30	27	53	.267	.331	.488	.819	480	127.4	.360	122	80.8
21	Dom DiMaggio D. DiMaggio	571	1,399	5,640	1,046	1,680	308	57	87	618	750	31	100	15	6,478	2,363	452	57			107	.298	.383	.419	.802	950	204.8	.377	112	97.9
22	Jimmie Foxx J. Foxx	568	887	3,288	721	1,051	181	45	222	788	624	6	38		3,934	1,988	448	16			57	.320	.429	.605	1.034	862	376.6	.460	152	288.8
23	Troy O'Leary T. O'Leary	562	962	3,456	490	954	209	37	117	516	276	23	12	19	3,788	1,588	363	5	28	25	93	.276	.331	.459	.791	499	18.9	.341	98	-9.6
24	Jarren Duran J. Duran	522	510	1,934	283	516	140	34	50	226	156	25	91	17	2,127	874	224	2	10	3	17	.267	.328	.452	.780	291	39.8	.336	111	27.8
25	Reggie Smith R. Smith	498	1,014	3,780	592	1,064	204	33	149	536	425	20	84	53	4,264	1,781	386	6	33	55	78	.281	.354	.471	.826	628	187.6	.368	129	134.3