David Ortiz has the most career RBIs against the Blue Jays, with 192 RBIs.

	NAME	RBI	G	AB	R	H	2B	3B	HR	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	David Ortiz D. Ortiz	192	251	929	159	258	70	2	62	140	4	194	1	2	1,077	518	134	0	4	22	20	.278	.373	.558	.931
2	Alex Rodriguez A. Rodriguez	178	242	923	160	248	50	0	58	112	18	228	22	6	1,060	472	108	0	7	13	31	.269	.357	.511	.868
3	Manny Ramirez M. Ramirez	140	190	687	128	192	29	2	54	112	8	155	2	1	813	387	85	0	6	15	26	.279	.384	.563	.947
4	Harold Baines H. Baines	131	221	773	89	230	29	4	38	71	1	106	5	4	848	381	71	0	3	9	22	.298	.356	.493	.849
5	Cal Ripken Jr. C. Ripken Jr.	129	242	936	118	247	45	4	30	68	5	103	2	0	1,016	390	79	0	7	10	24	.264	.315	.417	.732
6	Robin Yount R. Yount	129	204	798	130	263	41	15	25	81	1	93	22	8	895	409	81	6	9	13	13	.330	.388	.513	.901
7	Rafael Palmeiro R. Palmeiro	124	196	743	109	216	42	4	38	87	4	106	10	5	843	380	84	0	9	13	13	.291	.364	.511	.876
8	Bernie Williams B. Williams	121	197	750	127	204	39	5	25	87	2	134	9	11	844	328	69	0	5	7	19	.272	.347	.437	.784
9	Jason Giambi J. Giambi	116	175	607	85	168	33	1	36	101	13	124	1	1	730	311	70	0	9	4	13	.277	.386	.512	.899
10	Jose Canseco J. Canseco	114	127	484	82	135	28	1	41	57	8	149	13	7	557	288	70	0	8	4	5	.279	.359	.595	.954
11	George Brett G. Brett	113	163	624	117	200	56	11	22	88	3	47	18	7	725	344	89	1	9	24	15	.321	.402	.551	.953
12	Derek Jeter D. Jeter	110	269	1,087	186	341	50	8	24	108	18	210	31	7	1,228	479	82	11	4	4	25	.314	.384	.441	.824
13	Eddie Murray E. Murray	110	175	654	86	186	27	2	29	73	1	95	3	0	733	304	58	0	5	6	14	.284	.355	.465	.820
14	Dustin Pedroia D. Pedroia	107	177	714	100	212	47	3	22	65	2	70	15	5	789	331	72	2	6	3	14	.297	.355	.464	.818
15	Evan Longoria E. Longoria	106	178	663	101	188	47	5	25	78	5	140	5	0	755	320	77	0	9	13	26	.284	.359	.483	.842
16	Miguel Tejada M. Tejada	105	140	548	85	158	31	2	30	40	8	74	4	2	600	283	63	0	4	8	17	.288	.343	.516	.860
17	B.J. Surhoff	103	184	644	92	181	30	3	16	56	6	76	16	7	718	265	49	4	8	7	10	.281	.340	.411	.752
18	Chris Davis C. Davis	102	157	549	87	139	31	0	42	73	11	205	2	2	639	296	73	0	6	10	9	.253	.349	.539	.888
19	Jorge Posada J. Posada	102	186	633	99	187	41	1	31	75	11	146	2	1	722	323	73	0	3	10	20	.295	.378	.510	.888
20	Edgar Martinez E. Martinez	102	139	518	68	160	37	2	21	65	2	84	3	1	591	264	60	1	5	1	12	.309	.385	.510	.894
21	Jim Rice J. Rice	100	140	561	98	164	29	2	34	42	6	93	1	0	613	299	65	0	4	4	20	.292	.346	.533	.879
22	Robinson Cano R. Cano	99	175	670	94	190	56	2	23	45	13	90	4	3	739	319	81	2	9	6	19	.284	.336	.476	.813
23	Mark Teixeira M. Teixeira	99	141	511	70	136	36	1	36	68	6	106	3	2	590	282	73	0	5	9	13	.266	.356	.552	.908
24	Lou Whitaker L. Whitaker	99	204	762	115	216	41	9	16	96	3	87	10	5	882	323	66	9	12	6	12	.283	.361	.424	.785
25	Adam Jones A. Jones	98	192	750	102	206	30	2	36	46	11	153	11	5	809	348	68	1	1	3	30	.275	.325	.464	.789