Between the 1920 and 1929 seasons, Babe Ruth smashed the most home runs, with 467 homers.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	PA	TB	XBH	SH	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Babe Ruth B. Ruth	467	1,399	4,884	1,365	1,734	314	82	1,338	1,240	27	795	88	6,224	3,613	863	73	.355	.488	.740	1.228	1701	932.6	.535	206	884.9
2	Rogers Hornsby R. Hornsby	250	1,430	5,451	1,195	2,085	405	115	1,153	753	24	431	74	6,389	3,470	770	161	.382	.460	.637	1.096	1531	739.3	.490	186	714.6
3	Cy Williams C. Williams	202	1,239	4,274	721	1,327	200	47	715	490	43	401	58	4,883	2,227	449	76	.310	.387	.521	.908	864	264.4	.414	129	179
4	Ken Williams K. Williams	190	1,249	4,388	805	1,428	265	68	863	522	24	237	142	5,076	2,399	523	142	.325	.400	.547	.947	961	335.4	.429	137	256.2
5	Lou Gehrig L. Gehrig	146	767	2,746	631	919	206	72	635	480	15	351	30	3,321	1,707	424	80	.335	.436	.622	1.058	743	327.2	.470	170	313.1
6	Jim Bottomley J. Bottomley	146	1,062	4,134	711	1,354	261	104	885	406	24	337	40	4,690	2,261	511	126	.328	.391	.547	.938	869	282.6	.422	140	248.9
7	Bob Meusel B. Meusel	146	1,294	5,032	764	1,565	338	87	1,009	349	20	556	134	5,544	2,515	571	143	.311	.358	.500	.858	872	184.9	.389	119	141.2
8	Harry Heilmann H. Heilmann	142	1,417	5,285	962	1,924	397	101	1,131	615	25	324	70	6,115	2,949	640	190	.364	.433	.558	.991	1266	508.8	.450	153	441
9	Hack Wilson H. Wilson	137	755	2,747	530	864	154	50	604	360	18	388	39	3,202	1,529	341	77	.315	.397	.557	.954	611	211.3	.429	146	194.9
10	High Pockets Kelly H. Pockets Kelly	134	1,351	5,186	736	1,569	304	69	923	339	26	571	62	5,684	2,413	507	133	.303	.348	.465	.814	817	111.8	.371	114	102.1
11	Jack Fournier J. Fournier	121	1,059	3,748	621	1,213	186	69	657	424	61	256	78	4,340	1,900	376	107	.324	.401	.507	.908	778	243.1	.416	144	240.9
12	Al Simmons A. Simmons	115	820	3,282	559	1,169	237	60	713	206	9	248	49	3,578	1,871	412	81	.356	.396	.570	.966	697	247.5	.433	142	204.3
13	Goose Goslin G. Goslin	108	1,144	4,346	717	1,436	240	110	822	419	39	281	109	4,932	2,220	458	128	.330	.394	.511	.905	871	254.3	.412	134	224.9
14	Irish Meusel I. Meusel	97	1,029	3,904	588	1,230	199	80	698	224	14	165	71	4,247	1,880	376	105	.315	.354	.482	.836	640	117	.381	118	100.4
15	George Harper G. Harper	91	913	2,998	476	942	149	41	497	355	31	171	53	3,471	1,446	281	87	.314	.392	.482	.875	586	149.6	.402	125	115.1
16	Marty McManus M. McManus	91	1,257	4,649	740	1,360	273	73	734	442	23	414	86	5,274	2,052	437	160	.293	.357	.441	.798	742	80.9	.367	100	2.6
17	Chick Hafey C. Hafey	85	570	2,057	340	656	168	26	416	146	12	209	33	2,268	1,131	279	53	.319	.367	.550	.917	399	113.6	.410	130	92.3
18	Bing Miller B. Miller	85	1,178	4,306	671	1,385	264	75	687	237	61	257	97	4,777	2,054	424	173	.322	.366	.477	.843	738	140.2	.384	113	83.6
19	Gabby Hartnett G. Hartnett	81	709	2,198	303	630	143	31	364	252	17	260	22	2,521	1,078	255	54	.287	.364	.490	.855	398	84.9	.389	122	71.9
20	Travis Jackson T. Jackson	81	899	3,284	474	969	162	47	492	239	4	299	45	3,633	1,468	290	106	.295	.344	.447	.791	495	40.2	.362	106	26.3
21	Zack Wheat Z. Wheat	81	1,036	3,940	654	1,337	225	65	608	293	28	133	43	4,320	1,935	371	59	.339	.389	.491	.880	730	198	.404	134	185.2
22	Joe Hauser J. Hauser	80	629	2,044	351	580	103	28	356	250	21	229	19	2,370	979	211	55	.284	.368	.479	.847	371	78.9	.388	116	48.9
23	Tilly Walker T. Walker	79	496	1,815	291	516	91	18	298	189	14	178	16	2,062	880	188	44	.284	.356	.485	.841	317	66.9	.384	112	34.4
24	George Sisler G. Sisler	78	1,326	5,480	894	1,900	297	111	830	305	26	192	214	5,950	2,653	486	139	.347	.384	.484	.868	977	239.2	.398	119	146.1
25	Frankie Frisch F. Frisch	77	1,378	5,554	992	1,808	277	107	738	436	23	164	310	6,173	2,530	461	160	.326	.377	.456	.833	949	184	.384	120	161.2